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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 5-88234436-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=5&pos=88234436&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "5",
"pos": 88234436,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000296595.11",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.108-5908T>G",
"hgvs_p": null,
"transcript": "NM_153354.5",
"protein_id": "NP_699185.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 487,
"cds_start": -4,
"cds_end": null,
"cds_length": 1464,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2750,
"mane_select": "ENST00000296595.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.108-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000296595.11",
"protein_id": "ENSP00000296595.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 487,
"cds_start": -4,
"cds_end": null,
"cds_length": 1464,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2750,
"mane_select": "NM_153354.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "n.-274-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000510089.5",
"protein_id": "ENSP00000423380.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7608,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "n.108-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000511087.5",
"protein_id": "ENSP00000421805.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2804,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.-2992T>G",
"hgvs_p": null,
"transcript": "XM_047416810.1",
"protein_id": "XP_047272766.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 360,
"cds_start": -4,
"cds_end": null,
"cds_length": 1083,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 11559,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.108-5908T>G",
"hgvs_p": null,
"transcript": "NM_001349407.2",
"protein_id": "NP_001336336.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 534,
"cds_start": -4,
"cds_end": null,
"cds_length": 1605,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2834,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.108-5908T>G",
"hgvs_p": null,
"transcript": "NM_001289007.2",
"protein_id": "NP_001275936.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2050,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.108-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000514135.5",
"protein_id": "ENSP00000426354.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 502,
"cds_start": -4,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2035,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.75-5908T>G",
"hgvs_p": null,
"transcript": "NM_001289008.2",
"protein_id": "NP_001275937.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 476,
"cds_start": -4,
"cds_end": null,
"cds_length": 1431,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2882,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.75-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000512429.5",
"protein_id": "ENSP00000421498.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 476,
"cds_start": -4,
"cds_end": null,
"cds_length": 1431,
"cdna_start": null,
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"cdna_length": 1796,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.-401-5908T>G",
"hgvs_p": null,
"transcript": "NM_001349400.2",
"protein_id": "NP_001336329.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 305,
"cds_start": -4,
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"cds_length": 918,
"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 2,
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"gene_symbol": "TMEM161B",
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"hgvs_c": "c.-303-5908T>G",
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"transcript": "NM_001349402.2",
"protein_id": "NP_001336331.1",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 1,
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"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "c.-401-5908T>G",
"hgvs_p": null,
"transcript": "NM_001349403.2",
"protein_id": "NP_001336332.1",
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},
{
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"strand": false,
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],
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"exon_count": 10,
"intron_rank": 1,
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"gene_symbol": "TMEM161B",
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"hgvs_c": "c.-303-5908T>G",
"hgvs_p": null,
"transcript": "NM_001349405.2",
"protein_id": "NP_001336334.1",
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},
{
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],
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"gene_symbol": "TMEM161B",
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"hgvs_c": "c.-401-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000506536.5",
"protein_id": "ENSP00000421733.1",
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"cds_start": -4,
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"mane_select": null,
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"gene_symbol": "TMEM161B",
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"hgvs_c": "n.501-5908T>G",
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"transcript": "ENST00000503194.1",
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},
{
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],
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"gene_symbol": "TMEM161B",
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"hgvs_c": "n.110-5908T>G",
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"transcript": "ENST00000503755.5",
"protein_id": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "n.492-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000503943.5",
"protein_id": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 2,
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"gene_symbol": "TMEM161B",
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"hgvs_c": "n.108-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000507872.1",
"protein_id": "ENSP00000427312.1",
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},
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],
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"gene_symbol": "TMEM161B",
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},
{
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],
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},
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 2,
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"gene_symbol": "TMEM161B",
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"hgvs_c": "n.232-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000515477.5",
"protein_id": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TMEM161B",
"gene_hgnc_id": 28483,
"hgvs_c": "n.108-5908T>G",
"hgvs_p": null,
"transcript": "ENST00000850886.1",
"protein_id": "ENSP00000520925.1",
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"aa_start": null,
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},
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}