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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 6-123393673-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=123393673&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "6",
      "pos": 123393673,
      "ref": "C",
      "alt": "G",
      "effect": "synonymous_variant",
      "transcript": "NM_006073.4",
      "consequences": [
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "NM_006073.4",
          "protein_id": "NP_006064.2",
          "transcript_support_level": null,
          "aa_start": 352,
          "aa_end": null,
          "aa_length": 729,
          "cds_start": 1056,
          "cds_end": null,
          "cds_length": 2190,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000334268.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_006073.4"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "ENST00000334268.9",
          "protein_id": "ENSP00000333984.5",
          "transcript_support_level": 1,
          "aa_start": 352,
          "aa_end": null,
          "aa_length": 729,
          "cds_start": 1056,
          "cds_end": null,
          "cds_length": 2190,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_006073.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000334268.9"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1059G>C",
          "hgvs_p": "p.Pro353Pro",
          "transcript": "ENST00000962661.1",
          "protein_id": "ENSP00000632720.1",
          "transcript_support_level": null,
          "aa_start": 353,
          "aa_end": null,
          "aa_length": 730,
          "cds_start": 1059,
          "cds_end": null,
          "cds_length": 2193,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962661.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1059G>C",
          "hgvs_p": "p.Pro353Pro",
          "transcript": "ENST00000962654.1",
          "protein_id": "ENSP00000632713.1",
          "transcript_support_level": null,
          "aa_start": 353,
          "aa_end": null,
          "aa_length": 729,
          "cds_start": 1059,
          "cds_end": null,
          "cds_length": 2190,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962654.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1059G>C",
          "hgvs_p": "p.Pro353Pro",
          "transcript": "ENST00000962655.1",
          "protein_id": "ENSP00000632714.1",
          "transcript_support_level": null,
          "aa_start": 353,
          "aa_end": null,
          "aa_length": 729,
          "cds_start": 1059,
          "cds_end": null,
          "cds_length": 2190,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962655.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1059G>C",
          "hgvs_p": "p.Pro353Pro",
          "transcript": "ENST00000962660.1",
          "protein_id": "ENSP00000632719.1",
          "transcript_support_level": null,
          "aa_start": 353,
          "aa_end": null,
          "aa_length": 729,
          "cds_start": 1059,
          "cds_end": null,
          "cds_length": 2190,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962660.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1059G>C",
          "hgvs_p": "p.Pro353Pro",
          "transcript": "ENST00000962662.1",
          "protein_id": "ENSP00000632721.1",
          "transcript_support_level": null,
          "aa_start": 353,
          "aa_end": null,
          "aa_length": 729,
          "cds_start": 1059,
          "cds_end": null,
          "cds_length": 2190,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962662.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "ENST00000962653.1",
          "protein_id": "ENSP00000632712.1",
          "transcript_support_level": null,
          "aa_start": 352,
          "aa_end": null,
          "aa_length": 728,
          "cds_start": 1056,
          "cds_end": null,
          "cds_length": 2187,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962653.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "ENST00000962656.1",
          "protein_id": "ENSP00000632715.1",
          "transcript_support_level": null,
          "aa_start": 352,
          "aa_end": null,
          "aa_length": 728,
          "cds_start": 1056,
          "cds_end": null,
          "cds_length": 2187,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962656.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1059G>C",
          "hgvs_p": "p.Pro353Pro",
          "transcript": "ENST00000962663.1",
          "protein_id": "ENSP00000632722.1",
          "transcript_support_level": null,
          "aa_start": 353,
          "aa_end": null,
          "aa_length": 728,
          "cds_start": 1059,
          "cds_end": null,
          "cds_length": 2187,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962663.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1059G>C",
          "hgvs_p": "p.Pro353Pro",
          "transcript": "ENST00000962664.1",
          "protein_id": "ENSP00000632723.1",
          "transcript_support_level": null,
          "aa_start": 353,
          "aa_end": null,
          "aa_length": 728,
          "cds_start": 1059,
          "cds_end": null,
          "cds_length": 2187,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962664.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "ENST00000962659.1",
          "protein_id": "ENSP00000632718.1",
          "transcript_support_level": null,
          "aa_start": 352,
          "aa_end": null,
          "aa_length": 727,
          "cds_start": 1056,
          "cds_end": null,
          "cds_length": 2184,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962659.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
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          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "ENST00000962682.1",
          "protein_id": "ENSP00000632741.1",
          "transcript_support_level": null,
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          "aa_length": 727,
          "cds_start": 1056,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000962682.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1059G>C",
          "hgvs_p": "p.Pro353Pro",
          "transcript": "ENST00000962678.1",
          "protein_id": "ENSP00000632737.1",
          "transcript_support_level": null,
          "aa_start": 353,
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          "aa_length": 726,
          "cds_start": 1059,
          "cds_end": null,
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          "cdna_start": null,
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          "biotype": "protein_coding",
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        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 13,
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          "intron_rank": null,
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          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "ENST00000962674.1",
          "protein_id": "ENSP00000632733.1",
          "transcript_support_level": null,
          "aa_start": 352,
          "aa_end": null,
          "aa_length": 725,
          "cds_start": 1056,
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          "cds_length": 2178,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000962674.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "ENST00000962657.1",
          "protein_id": "ENSP00000632716.1",
          "transcript_support_level": null,
          "aa_start": 352,
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          "aa_length": 719,
          "cds_start": 1056,
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          "cds_length": 2160,
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          "biotype": "protein_coding",
          "feature": "ENST00000962657.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1059G>C",
          "hgvs_p": "p.Pro353Pro",
          "transcript": "ENST00000962666.1",
          "protein_id": "ENSP00000632725.1",
          "transcript_support_level": null,
          "aa_start": 353,
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        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
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          "exon_count": 40,
          "intron_rank": null,
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          "gene_symbol": "TRDN",
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          "hgvs_c": "c.1056G>C",
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          "transcript": "ENST00000962671.1",
          "protein_id": "ENSP00000632730.1",
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        },
        {
          "aa_ref": "P",
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          "strand": false,
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          ],
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          "gene_symbol": "TRDN",
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          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "ENST00000962673.1",
          "protein_id": "ENSP00000632732.1",
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          "aa_start": 352,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000962673.1"
        },
        {
          "aa_ref": "P",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TRDN",
          "gene_hgnc_id": 12261,
          "hgvs_c": "c.1056G>C",
          "hgvs_p": "p.Pro352Pro",
          "transcript": "ENST00000962676.1",
          "protein_id": "ENSP00000632735.1",
          "transcript_support_level": null,
          "aa_start": 352,
          "aa_end": null,
          "aa_length": 718,
          "cds_start": 1056,
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          "cdna_start": null,
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          "cdna_length": null,
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