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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-170306872-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=170306872&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 170306872,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001286380.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-22+30T>C",
"hgvs_p": null,
"transcript": "NM_032448.3",
"protein_id": "NP_115824.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 910,
"cds_start": null,
"cds_end": null,
"cds_length": 2733,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5155,
"mane_select": "ENST00000476287.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032448.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-22+30T>C",
"hgvs_p": null,
"transcript": "ENST00000476287.4",
"protein_id": "ENSP00000417970.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 910,
"cds_start": null,
"cds_end": null,
"cds_length": 2733,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5155,
"mane_select": "NM_032448.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000476287.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.49-10498T>C",
"hgvs_p": null,
"transcript": "NM_001286380.2",
"protein_id": "NP_001273309.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 933,
"cds_start": null,
"cds_end": null,
"cds_length": 2802,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5203,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286380.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.49-10498T>C",
"hgvs_p": null,
"transcript": "ENST00000537664.5",
"protein_id": "ENSP00000440125.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 933,
"cds_start": null,
"cds_end": null,
"cds_length": 2802,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3212,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000537664.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.16-10498T>C",
"hgvs_p": null,
"transcript": "NM_001286379.2",
"protein_id": "NP_001273308.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 922,
"cds_start": null,
"cds_end": null,
"cds_length": 2769,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5440,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286379.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.16-10498T>C",
"hgvs_p": null,
"transcript": "ENST00000630384.2",
"protein_id": "ENSP00000485745.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 922,
"cds_start": null,
"cds_end": null,
"cds_length": 2769,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3721,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000630384.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-22+30T>C",
"hgvs_p": null,
"transcript": "ENST00000901518.1",
"protein_id": "ENSP00000571577.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 910,
"cds_start": null,
"cds_end": null,
"cds_length": 2733,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4105,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901518.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-22+30T>C",
"hgvs_p": null,
"transcript": "ENST00000901520.1",
"protein_id": "ENSP00000571579.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 910,
"cds_start": null,
"cds_end": null,
"cds_length": 2733,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5135,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901520.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-193+30T>C",
"hgvs_p": null,
"transcript": "ENST00000901522.1",
"protein_id": "ENSP00000571581.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 910,
"cds_start": null,
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"cds_length": 2733,
"cdna_start": null,
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"cdna_length": 3338,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000901522.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-22+1016T>C",
"hgvs_p": null,
"transcript": "ENST00000966364.1",
"protein_id": "ENSP00000636423.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 910,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000966364.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 1,
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"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-22+30T>C",
"hgvs_p": null,
"transcript": "ENST00000966365.1",
"protein_id": "ENSP00000636424.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "FAM120B",
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"transcript": "ENST00000966367.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "FAM120B",
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},
{
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],
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"gene_symbol": "FAM120B",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 2,
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"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-22+1016T>C",
"hgvs_p": null,
"transcript": "ENST00000915624.1",
"protein_id": "ENSP00000585683.1",
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},
{
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],
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"gene_symbol": "FAM120B",
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},
{
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],
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"gene_symbol": "FAM120B",
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"hgvs_c": "c.-22+30T>C",
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"transcript": "ENST00000901517.1",
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},
{
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],
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"exon_count": 11,
"intron_rank": 1,
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"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-22+30T>C",
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"transcript": "ENST00000966371.1",
"protein_id": "ENSP00000636430.1",
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},
{
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],
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},
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],
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},
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],
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"gene_symbol": "FAM120B",
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"hgvs_c": "c.-22+30T>C",
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"transcript": "ENST00000966370.1",
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"feature": "ENST00000966370.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 1,
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"gene_symbol": "FAM120B",
"gene_hgnc_id": 21109,
"hgvs_c": "c.-22+30T>C",
"hgvs_p": null,
"transcript": "ENST00000966368.1",
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},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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