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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-25600740-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=25600740&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 25600740,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_017640.6",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "NM_017640.6",
"protein_id": "NP_060110.4",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1371,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000329474.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_017640.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "ENST00000329474.7",
"protein_id": "ENSP00000331983.6",
"transcript_support_level": 1,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1371,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_017640.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000329474.7"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "ENST00000865798.1",
"protein_id": "ENSP00000535857.1",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1421,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865798.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "ENST00000911480.1",
"protein_id": "ENSP00000581539.1",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1371,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000911480.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "ENST00000911481.1",
"protein_id": "ENSP00000581540.1",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1370,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4113,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000911481.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3558G>T",
"hgvs_p": "p.Ala1186Ala",
"transcript": "ENST00000967820.1",
"protein_id": "ENSP00000637879.1",
"transcript_support_level": null,
"aa_start": 1186,
"aa_end": null,
"aa_length": 1369,
"cds_start": 3558,
"cds_end": null,
"cds_length": 4110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967820.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "NM_001173977.2",
"protein_id": "NP_001167448.1",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1365,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4098,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001173977.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "ENST00000700669.1",
"protein_id": "ENSP00000515137.1",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1365,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4098,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000700669.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 32,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3447G>T",
"hgvs_p": "p.Ala1149Ala",
"transcript": "ENST00000865797.1",
"protein_id": "ENSP00000535856.1",
"transcript_support_level": null,
"aa_start": 1149,
"aa_end": null,
"aa_length": 1338,
"cds_start": 3447,
"cds_end": null,
"cds_length": 4017,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865797.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3309G>T",
"hgvs_p": "p.Ala1103Ala",
"transcript": "ENST00000911482.1",
"protein_id": "ENSP00000581541.1",
"transcript_support_level": null,
"aa_start": 1103,
"aa_end": null,
"aa_length": 1292,
"cds_start": 3309,
"cds_end": null,
"cds_length": 3879,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000911482.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 34,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3309G>T",
"hgvs_p": "p.Ala1103Ala",
"transcript": "ENST00000865799.1",
"protein_id": "ENSP00000535858.1",
"transcript_support_level": null,
"aa_start": 1103,
"aa_end": null,
"aa_length": 1286,
"cds_start": 3309,
"cds_end": null,
"cds_length": 3861,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000865799.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3576G>T",
"hgvs_p": "p.Ala1192Ala",
"transcript": "XM_017011008.2",
"protein_id": "XP_016866497.1",
"transcript_support_level": null,
"aa_start": 1192,
"aa_end": null,
"aa_length": 1431,
"cds_start": 3576,
"cds_end": null,
"cds_length": 4296,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017011008.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3576G>T",
"hgvs_p": "p.Ala1192Ala",
"transcript": "XM_017011009.2",
"protein_id": "XP_016866498.1",
"transcript_support_level": null,
"aa_start": 1192,
"aa_end": null,
"aa_length": 1430,
"cds_start": 3576,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017011009.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3564G>T",
"hgvs_p": "p.Ala1188Ala",
"transcript": "XM_017011010.2",
"protein_id": "XP_016866499.1",
"transcript_support_level": null,
"aa_start": 1188,
"aa_end": null,
"aa_length": 1427,
"cds_start": 3564,
"cds_end": null,
"cds_length": 4284,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017011010.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3558G>T",
"hgvs_p": "p.Ala1186Ala",
"transcript": "XM_017011011.2",
"protein_id": "XP_016866500.1",
"transcript_support_level": null,
"aa_start": 1186,
"aa_end": null,
"aa_length": 1425,
"cds_start": 3558,
"cds_end": null,
"cds_length": 4278,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017011011.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3576G>T",
"hgvs_p": "p.Ala1192Ala",
"transcript": "XM_017011012.2",
"protein_id": "XP_016866501.1",
"transcript_support_level": null,
"aa_start": 1192,
"aa_end": null,
"aa_length": 1425,
"cds_start": 3576,
"cds_end": null,
"cds_length": 4278,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017011012.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3576G>T",
"hgvs_p": "p.Ala1192Ala",
"transcript": "XM_024446484.2",
"protein_id": "XP_024302252.1",
"transcript_support_level": null,
"aa_start": 1192,
"aa_end": null,
"aa_length": 1424,
"cds_start": 3576,
"cds_end": null,
"cds_length": 4275,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446484.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "XM_005249218.2",
"protein_id": "XP_005249275.1",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1421,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005249218.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "XM_047418994.1",
"protein_id": "XP_047274950.1",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1420,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4263,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047418994.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3558G>T",
"hgvs_p": "p.Ala1186Ala",
"transcript": "XM_017011013.2",
"protein_id": "XP_016866502.1",
"transcript_support_level": null,
"aa_start": 1186,
"aa_end": null,
"aa_length": 1419,
"cds_start": 3558,
"cds_end": null,
"cds_length": 4260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017011013.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3546G>T",
"hgvs_p": "p.Ala1182Ala",
"transcript": "XM_047418995.1",
"protein_id": "XP_047274951.1",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1415,
"cds_start": 3546,
"cds_end": null,
"cds_length": 4248,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047418995.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 32,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CARMIL1",
"gene_hgnc_id": 21581,
"hgvs_c": "c.3486G>T",
"hgvs_p": "p.Ala1162Ala",
"transcript": "XM_047418996.1",
"protein_id": "XP_047274952.1",
"transcript_support_level": null,
"aa_start": 1162,
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}
],
"message": null
}