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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-25779164-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=25779164&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 25779164,
"ref": "A",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "NM_005495.3",
"consequences": [
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "NM_005495.3",
"protein_id": "NP_005486.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 497,
"cds_start": 1470,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000377905.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005495.3"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "ENST00000377905.9",
"protein_id": "ENSP00000367137.4",
"transcript_support_level": 1,
"aa_start": 490,
"aa_end": null,
"aa_length": 497,
"cds_start": 1470,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005495.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377905.9"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "ENST00000867588.1",
"protein_id": "ENSP00000537647.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 497,
"cds_start": 1470,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867588.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "ENST00000867590.1",
"protein_id": "ENSP00000537649.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 497,
"cds_start": 1470,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867590.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "ENST00000867592.1",
"protein_id": "ENSP00000537651.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 497,
"cds_start": 1470,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867592.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "ENST00000867598.1",
"protein_id": "ENSP00000537657.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 497,
"cds_start": 1470,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867598.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "ENST00000957018.1",
"protein_id": "ENSP00000627077.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 497,
"cds_start": 1470,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000957018.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1308A>G",
"hgvs_p": "p.Lys436Lys",
"transcript": "NM_001286121.1",
"protein_id": "NP_001273050.1",
"transcript_support_level": null,
"aa_start": 436,
"aa_end": null,
"aa_length": 443,
"cds_start": 1308,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001286121.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1308A>G",
"hgvs_p": "p.Lys436Lys",
"transcript": "ENST00000439485.6",
"protein_id": "ENSP00000391345.3",
"transcript_support_level": 5,
"aa_start": 436,
"aa_end": null,
"aa_length": 443,
"cds_start": 1308,
"cds_end": null,
"cds_length": 1332,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000439485.6"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1236A>G",
"hgvs_p": "p.Lys412Lys",
"transcript": "ENST00000867595.1",
"protein_id": "ENSP00000537654.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 419,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867595.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1236A>G",
"hgvs_p": "p.Lys412Lys",
"transcript": "ENST00000867596.1",
"protein_id": "ENSP00000537655.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 419,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867596.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1236A>G",
"hgvs_p": "p.Lys412Lys",
"transcript": "ENST00000867600.1",
"protein_id": "ENSP00000537659.1",
"transcript_support_level": null,
"aa_start": 412,
"aa_end": null,
"aa_length": 419,
"cds_start": 1236,
"cds_end": null,
"cds_length": 1260,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867600.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1176A>G",
"hgvs_p": "p.Lys392Lys",
"transcript": "ENST00000867589.1",
"protein_id": "ENSP00000537648.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 399,
"cds_start": 1176,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867589.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1176A>G",
"hgvs_p": "p.Lys392Lys",
"transcript": "ENST00000867594.1",
"protein_id": "ENSP00000537653.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 399,
"cds_start": 1176,
"cds_end": null,
"cds_length": 1200,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867594.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1113A>G",
"hgvs_p": "p.Lys371Lys",
"transcript": "ENST00000867597.1",
"protein_id": "ENSP00000537656.1",
"transcript_support_level": null,
"aa_start": 371,
"aa_end": null,
"aa_length": 378,
"cds_start": 1113,
"cds_end": null,
"cds_length": 1137,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867597.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1065A>G",
"hgvs_p": "p.Lys355Lys",
"transcript": "ENST00000867599.1",
"protein_id": "ENSP00000537658.1",
"transcript_support_level": null,
"aa_start": 355,
"aa_end": null,
"aa_length": 362,
"cds_start": 1065,
"cds_end": null,
"cds_length": 1089,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867599.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.942A>G",
"hgvs_p": "p.Lys314Lys",
"transcript": "ENST00000867591.1",
"protein_id": "ENSP00000537650.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 321,
"cds_start": 942,
"cds_end": null,
"cds_length": 966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867591.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.942A>G",
"hgvs_p": "p.Lys314Lys",
"transcript": "ENST00000867593.1",
"protein_id": "ENSP00000537652.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 321,
"cds_start": 942,
"cds_end": null,
"cds_length": 966,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867593.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.780A>G",
"hgvs_p": "p.Lys260Lys",
"transcript": "ENST00000867587.1",
"protein_id": "ENSP00000537646.1",
"transcript_support_level": null,
"aa_start": 260,
"aa_end": null,
"aa_length": 267,
"cds_start": 780,
"cds_end": null,
"cds_length": 804,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867587.1"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "XM_024446294.2",
"protein_id": "XP_024302062.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 497,
"cds_start": 1470,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446294.2"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "XM_024446295.2",
"protein_id": "XP_024302063.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
"aa_length": 497,
"cds_start": 1470,
"cds_end": null,
"cds_length": 1494,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_024446295.2"
},
{
"aa_ref": "K",
"aa_alt": "K",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SLC17A4",
"gene_hgnc_id": 10932,
"hgvs_c": "c.1470A>G",
"hgvs_p": "p.Lys490Lys",
"transcript": "XM_024446296.2",
"protein_id": "XP_024302064.1",
"transcript_support_level": null,
"aa_start": 490,
"aa_end": null,
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}
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}