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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-32352376-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=32352376&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 32352376,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000533191.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.260-2616C>G",
"hgvs_p": null,
"transcript": "NM_001286474.2",
"protein_id": "NP_001273403.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 561,
"cds_start": -4,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2166,
"mane_select": "ENST00000533191.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.260-2616C>G",
"hgvs_p": null,
"transcript": "ENST00000533191.6",
"protein_id": "ENSP00000431199.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 561,
"cds_start": -4,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2166,
"mane_select": "NM_001286474.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.239-2616C>G",
"hgvs_p": null,
"transcript": "ENST00000442822.6",
"protein_id": "ENSP00000411164.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 468,
"cds_start": -4,
"cds_end": null,
"cds_length": 1407,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1696,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.260-2547C>G",
"hgvs_p": null,
"transcript": "NM_006781.5",
"protein_id": "NP_006772.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 563,
"cds_start": -4,
"cds_end": null,
"cds_length": 1692,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2172,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.260-2547C>G",
"hgvs_p": null,
"transcript": "ENST00000447241.6",
"protein_id": "ENSP00000415517.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 563,
"cds_start": -4,
"cds_end": null,
"cds_length": 1692,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2148,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.260-2616C>G",
"hgvs_p": null,
"transcript": "ENST00000375015.8",
"protein_id": "ENSP00000364155.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 562,
"cds_start": -4,
"cds_end": null,
"cds_length": 1689,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2173,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.239-2616C>G",
"hgvs_p": null,
"transcript": "NM_001286475.2",
"protein_id": "NP_001273404.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 547,
"cds_start": -4,
"cds_end": null,
"cds_length": 1644,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2124,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.239-2616C>G",
"hgvs_p": null,
"transcript": "ENST00000527965.5",
"protein_id": "ENSP00000435103.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 547,
"cds_start": -4,
"cds_end": null,
"cds_length": 1644,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2076,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.101-2616C>G",
"hgvs_p": null,
"transcript": "ENST00000698834.1",
"protein_id": "ENSP00000513970.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 277,
"cds_start": -4,
"cds_end": null,
"cds_length": 835,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 837,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.272-2616C>G",
"hgvs_p": null,
"transcript": "ENST00000532023.5",
"protein_id": "ENSP00000432814.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 131,
"cds_start": -4,
"cds_end": null,
"cds_length": 397,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 563,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "TSBP1",
"gene_hgnc_id": 13922,
"hgvs_c": "c.260-2547C>G",
"hgvs_p": null,
"transcript": "ENST00000534588.1",
"protein_id": "ENSP00000432566.1",
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"aa_start": null,
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"aa_length": 124,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 549,
"mane_select": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "TSBP1-AS1",
"gene_hgnc_id": 39756,
"hgvs_c": "n.109-13404G>C",
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"transcript": "ENST00000642577.1",
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},
{
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"strand": true,
"consequences": [
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],
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"exon_count": 4,
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"gene_symbol": "TSBP1-AS1",
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"hgvs_c": "n.65-13404G>C",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "TSBP1-AS1",
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"hgvs_c": "n.88-37838G>C",
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},
{
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],
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},
{
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],
"exon_rank": null,
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"gene_symbol": "TSBP1-AS1",
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"hgvs_c": "n.279-13404G>C",
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},
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],
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"gene_symbol": "TSBP1-AS1",
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},
{
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],
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"exon_count": 3,
"intron_rank": 2,
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"gene_symbol": "TSBP1-AS1",
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"hgvs_c": "n.563+2379G>C",
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"transcript": "ENST00000647036.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 2,
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"gene_symbol": "TSBP1-AS1",
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"hgvs_c": "n.307-13404G>C",
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},
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],
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],
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},
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],
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"intron_rank": 2,
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"gene_symbol": "TSBP1-AS1",
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"hgvs_c": "n.818-13404G>C",
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"transcript": "ENST00000685706.2",
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"feature": null
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "TSBP1-AS1",
"gene_hgnc_id": 39756,
"hgvs_c": "n.796-37838G>C",
"hgvs_p": null,
"transcript": "ENST00000690046.2",
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},
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"protein_coding": false,
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{
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],
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}
],
"message": null
}