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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-35421842-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=35421842&ref=G&alt=A&genome=hg38&allGenes=true"
API Response
json
{
"variants": [
{
"chr": "6",
"pos": 35421842,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_006238.5",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "NM_006238.5",
"protein_id": "NP_006229.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 617,
"cdna_end": null,
"cdna_length": 3734,
"mane_select": "ENST00000360694.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "ENST00000360694.8",
"protein_id": "ENSP00000353916.3",
"transcript_support_level": 2,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 617,
"cdna_end": null,
"cdna_length": 3734,
"mane_select": "NM_006238.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "NM_001171818.2",
"protein_id": "NP_001165289.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 713,
"cdna_end": null,
"cdna_length": 3830,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "ENST00000311565.4",
"protein_id": "ENSP00000310928.4",
"transcript_support_level": 5,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 657,
"cdna_end": null,
"cdna_length": 3774,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.191G>A",
"hgvs_p": "p.Arg64His",
"transcript": "NM_001171819.2",
"protein_id": "NP_001165290.1",
"transcript_support_level": null,
"aa_start": 64,
"aa_end": null,
"aa_length": 402,
"cds_start": 191,
"cds_end": null,
"cds_length": 1209,
"cdna_start": 386,
"cdna_end": null,
"cdna_length": 3503,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.191G>A",
"hgvs_p": "p.Arg64His",
"transcript": "ENST00000448077.6",
"protein_id": "ENSP00000414372.2",
"transcript_support_level": 2,
"aa_start": 64,
"aa_end": null,
"aa_length": 402,
"cds_start": 191,
"cds_end": null,
"cds_length": 1209,
"cdna_start": 386,
"cdna_end": null,
"cdna_length": 3516,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "NM_177435.3",
"protein_id": "NP_803184.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 361,
"cds_start": 308,
"cds_end": null,
"cds_length": 1086,
"cdna_start": 617,
"cdna_end": null,
"cdna_length": 2008,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "ENST00000337400.6",
"protein_id": "ENSP00000337063.2",
"transcript_support_level": 5,
"aa_start": 103,
"aa_end": null,
"aa_length": 361,
"cds_start": 308,
"cds_end": null,
"cds_length": 1086,
"cdna_start": 657,
"cdna_end": null,
"cdna_length": 2041,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_005249193.2",
"protein_id": "XP_005249250.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 645,
"cdna_end": null,
"cdna_length": 3762,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_006715123.2",
"protein_id": "XP_006715186.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 533,
"cdna_end": null,
"cdna_length": 3650,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_011514707.2",
"protein_id": "XP_011513009.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 1380,
"cdna_end": null,
"cdna_length": 4497,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_011514710.2",
"protein_id": "XP_011513012.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 707,
"cdna_end": null,
"cdna_length": 3824,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_017010973.2",
"protein_id": "XP_016866462.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
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"cds_length": 1326,
"cdna_start": 842,
"cdna_end": null,
"cdna_length": 3959,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_017010974.2",
"protein_id": "XP_016866463.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
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"cdna_start": 767,
"cdna_end": null,
"cdna_length": 3884,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_047418915.1",
"protein_id": "XP_047274871.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 1009,
"cdna_end": null,
"cdna_length": 4126,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_047418916.1",
"protein_id": "XP_047274872.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
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"cdna_start": 739,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_047418917.1",
"protein_id": "XP_047274873.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 945,
"cdna_end": null,
"cdna_length": 4062,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_047418918.1",
"protein_id": "XP_047274874.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 785,
"cdna_end": null,
"cdna_length": 3902,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_047418919.1",
"protein_id": "XP_047274875.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
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"cdna_start": 1629,
"cdna_end": null,
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"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_047418920.1",
"protein_id": "XP_047274876.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
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"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_047418921.1",
"protein_id": "XP_047274877.1",
"transcript_support_level": null,
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"cds_start": 308,
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"cdna_start": 1469,
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"cdna_length": 4586,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_047418922.1",
"protein_id": "XP_047274878.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
"cds_start": 308,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 1754,
"cdna_end": null,
"cdna_length": 4871,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.308G>A",
"hgvs_p": "p.Arg103His",
"transcript": "XM_047418923.1",
"protein_id": "XP_047274879.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 441,
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}