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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-35424654-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=35424654&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 35424654,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_006238.5",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "NM_006238.5",
"protein_id": "NP_006229.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 1262,
"cdna_end": null,
"cdna_length": 3734,
"mane_select": "ENST00000360694.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "ENST00000360694.8",
"protein_id": "ENSP00000353916.3",
"transcript_support_level": 2,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 1262,
"cdna_end": null,
"cdna_length": 3734,
"mane_select": "NM_006238.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "NM_001171818.2",
"protein_id": "NP_001165289.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 1358,
"cdna_end": null,
"cdna_length": 3830,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "ENST00000311565.4",
"protein_id": "ENSP00000310928.4",
"transcript_support_level": 5,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 1302,
"cdna_end": null,
"cdna_length": 3774,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.836G>A",
"hgvs_p": "p.Arg279His",
"transcript": "NM_001171819.2",
"protein_id": "NP_001165290.1",
"transcript_support_level": null,
"aa_start": 279,
"aa_end": null,
"aa_length": 402,
"cds_start": 836,
"cds_end": null,
"cds_length": 1209,
"cdna_start": 1031,
"cdna_end": null,
"cdna_length": 3503,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.836G>A",
"hgvs_p": "p.Arg279His",
"transcript": "ENST00000448077.6",
"protein_id": "ENSP00000414372.2",
"transcript_support_level": 2,
"aa_start": 279,
"aa_end": null,
"aa_length": 402,
"cds_start": 836,
"cds_end": null,
"cds_length": 1209,
"cdna_start": 1031,
"cdna_end": null,
"cdna_length": 3516,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "NM_177435.3",
"protein_id": "NP_803184.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 361,
"cds_start": 953,
"cds_end": null,
"cds_length": 1086,
"cdna_start": 1262,
"cdna_end": null,
"cdna_length": 2008,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "ENST00000337400.6",
"protein_id": "ENSP00000337063.2",
"transcript_support_level": 5,
"aa_start": 318,
"aa_end": null,
"aa_length": 361,
"cds_start": 953,
"cds_end": null,
"cds_length": 1086,
"cdna_start": 1302,
"cdna_end": null,
"cdna_length": 2041,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.659G>A",
"hgvs_p": "p.Arg220His",
"transcript": "NM_001171820.2",
"protein_id": "NP_001165291.1",
"transcript_support_level": null,
"aa_start": 220,
"aa_end": null,
"aa_length": 343,
"cds_start": 659,
"cds_end": null,
"cds_length": 1032,
"cdna_start": 968,
"cdna_end": null,
"cdna_length": 3440,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.659G>A",
"hgvs_p": "p.Arg220His",
"transcript": "ENST00000418635.6",
"protein_id": "ENSP00000413314.2",
"transcript_support_level": 2,
"aa_start": 220,
"aa_end": null,
"aa_length": 343,
"cds_start": 659,
"cds_end": null,
"cds_length": 1032,
"cdna_start": 968,
"cdna_end": null,
"cdna_length": 3453,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_005249193.2",
"protein_id": "XP_005249250.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 1290,
"cdna_end": null,
"cdna_length": 3762,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_006715123.2",
"protein_id": "XP_006715186.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
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"cds_length": 1326,
"cdna_start": 1178,
"cdna_end": null,
"cdna_length": 3650,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_011514707.2",
"protein_id": "XP_011513009.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
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"cds_length": 1326,
"cdna_start": 2025,
"cdna_end": null,
"cdna_length": 4497,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_011514710.2",
"protein_id": "XP_011513012.1",
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"aa_start": 318,
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"cds_start": 953,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
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"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_017010973.2",
"protein_id": "XP_016866462.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
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"cdna_start": 1487,
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"cdna_length": 3959,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_017010974.2",
"protein_id": "XP_016866463.1",
"transcript_support_level": null,
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"aa_end": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_047418915.1",
"protein_id": "XP_047274871.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
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"cdna_start": 1654,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_047418916.1",
"protein_id": "XP_047274872.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
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"cdna_start": 1384,
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"cdna_length": 3856,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_047418917.1",
"protein_id": "XP_047274873.1",
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"aa_end": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 8,
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"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_047418918.1",
"protein_id": "XP_047274874.1",
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"aa_end": null,
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"cds_start": 953,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
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"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_047418919.1",
"protein_id": "XP_047274875.1",
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"cdna_start": 2274,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_047418920.1",
"protein_id": "XP_047274876.1",
"transcript_support_level": null,
"aa_start": 318,
"aa_end": null,
"aa_length": 441,
"cds_start": 953,
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"cds_length": 1326,
"cdna_start": 2128,
"cdna_end": null,
"cdna_length": 4600,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "R",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPARD",
"gene_hgnc_id": 9235,
"hgvs_c": "c.953G>A",
"hgvs_p": "p.Arg318His",
"transcript": "XM_047418921.1",
"protein_id": "XP_047274877.1",
"transcript_support_level": null,
"aa_start": 318,
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}