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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 6-87629034-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=6&pos=87629034&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "6",
"pos": 87629034,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_181837.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1186-5811T>C",
"hgvs_p": null,
"transcript": "NM_012381.4",
"protein_id": "NP_036513.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 711,
"cds_start": null,
"cds_end": null,
"cds_length": 2136,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000392844.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012381.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1186-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000392844.8",
"protein_id": "ENSP00000376586.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 711,
"cds_start": null,
"cds_end": null,
"cds_length": 2136,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_012381.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000392844.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1186-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000257789.4",
"protein_id": "ENSP00000257789.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 712,
"cds_start": null,
"cds_end": null,
"cds_length": 2139,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000257789.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1186-5811T>C",
"hgvs_p": null,
"transcript": "NM_181837.3",
"protein_id": "NP_862820.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 712,
"cds_start": null,
"cds_end": null,
"cds_length": 2139,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_181837.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1183-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000911372.1",
"protein_id": "ENSP00000581431.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 711,
"cds_start": null,
"cds_end": null,
"cds_length": 2136,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000911372.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1183-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000891530.1",
"protein_id": "ENSP00000561589.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 710,
"cds_start": null,
"cds_end": null,
"cds_length": 2133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891530.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1186-5814T>C",
"hgvs_p": null,
"transcript": "ENST00000954635.1",
"protein_id": "ENSP00000624694.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 710,
"cds_start": null,
"cds_end": null,
"cds_length": 2133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954635.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1186-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000891532.1",
"protein_id": "ENSP00000561591.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 706,
"cds_start": null,
"cds_end": null,
"cds_length": 2121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891532.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1186-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000891535.1",
"protein_id": "ENSP00000561594.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 706,
"cds_start": null,
"cds_end": null,
"cds_length": 2121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000891535.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1168-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000954637.1",
"protein_id": "ENSP00000624696.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 706,
"cds_start": null,
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"cds_length": 2121,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954637.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1156-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000891531.1",
"protein_id": "ENSP00000561590.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 702,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000891531.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
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"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1156-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000891529.1",
"protein_id": "ENSP00000561588.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 701,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000891529.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1186-5811T>C",
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"transcript": "ENST00000850561.1",
"protein_id": "ENSP00000520852.1",
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "ORC3",
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"hgvs_c": "c.1186-5910T>C",
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"transcript": "ENST00000954639.1",
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"feature": "ENST00000954639.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1072-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000891528.1",
"protein_id": "ENSP00000561587.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": true,
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"intron_variant"
],
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"exon_count": 19,
"intron_rank": 10,
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"gene_symbol": "ORC3",
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"hgvs_c": "c.1072-5811T>C",
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"transcript": "ENST00000891527.1",
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"biotype": "protein_coding",
"feature": "ENST00000891527.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1185+7021T>C",
"hgvs_p": null,
"transcript": "ENST00000911373.1",
"protein_id": "ENSP00000581432.1",
"transcript_support_level": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000911373.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.1185+7021T>C",
"hgvs_p": null,
"transcript": "ENST00000891533.1",
"protein_id": "ENSP00000561592.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"feature": "ENST00000891533.1"
},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ORC3",
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"hgvs_c": "c.1072-5814T>C",
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"transcript": "ENST00000954640.1",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
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"exon_count": 19,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "ORC3",
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"hgvs_c": "c.1081-5811T>C",
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"transcript": "ENST00000891536.1",
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"feature": "ENST00000891536.1"
},
{
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"strand": true,
"consequences": [
"intron_variant"
],
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"intron_rank": 10,
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"gene_symbol": "ORC3",
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"hgvs_c": "c.1072-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000954638.1",
"protein_id": "ENSP00000624697.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954638.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "ORC3",
"gene_hgnc_id": 8489,
"hgvs_c": "c.967-5811T>C",
"hgvs_p": null,
"transcript": "ENST00000911374.1",
"protein_id": "ENSP00000581433.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 638,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000911374.1"
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
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