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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-100575281-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=100575281&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 100575281,
"ref": "A",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "NM_002319.5",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1878T>C",
"hgvs_p": "p.Asp626Asp",
"transcript": "NM_002319.5",
"protein_id": "NP_002310.2",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 683,
"cds_start": 1878,
"cds_end": null,
"cds_length": 2052,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000310300.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002319.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1878T>C",
"hgvs_p": "p.Asp626Asp",
"transcript": "ENST00000310300.11",
"protein_id": "ENSP00000309689.6",
"transcript_support_level": 1,
"aa_start": 626,
"aa_end": null,
"aa_length": 683,
"cds_start": 1878,
"cds_end": null,
"cds_length": 2052,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_002319.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000310300.11"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1890T>C",
"hgvs_p": "p.Asp630Asp",
"transcript": "ENST00000877649.1",
"protein_id": "ENSP00000547708.1",
"transcript_support_level": null,
"aa_start": 630,
"aa_end": null,
"aa_length": 687,
"cds_start": 1890,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877649.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1875T>C",
"hgvs_p": "p.Asp625Asp",
"transcript": "ENST00000965051.1",
"protein_id": "ENSP00000635110.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 682,
"cds_start": 1875,
"cds_end": null,
"cds_length": 2049,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965051.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1872T>C",
"hgvs_p": "p.Asp624Asp",
"transcript": "ENST00000877651.1",
"protein_id": "ENSP00000547710.1",
"transcript_support_level": null,
"aa_start": 624,
"aa_end": null,
"aa_length": 681,
"cds_start": 1872,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877651.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1872T>C",
"hgvs_p": "p.Asp624Asp",
"transcript": "ENST00000913367.1",
"protein_id": "ENSP00000583426.1",
"transcript_support_level": null,
"aa_start": 624,
"aa_end": null,
"aa_length": 681,
"cds_start": 1872,
"cds_end": null,
"cds_length": 2046,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913367.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1863T>C",
"hgvs_p": "p.Asp621Asp",
"transcript": "ENST00000913368.1",
"protein_id": "ENSP00000583427.1",
"transcript_support_level": null,
"aa_start": 621,
"aa_end": null,
"aa_length": 678,
"cds_start": 1863,
"cds_end": null,
"cds_length": 2037,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913368.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1815T>C",
"hgvs_p": "p.Asp605Asp",
"transcript": "ENST00000877644.1",
"protein_id": "ENSP00000547703.1",
"transcript_support_level": null,
"aa_start": 605,
"aa_end": null,
"aa_length": 662,
"cds_start": 1815,
"cds_end": null,
"cds_length": 1989,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877644.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1809T>C",
"hgvs_p": "p.Asp603Asp",
"transcript": "ENST00000877643.1",
"protein_id": "ENSP00000547702.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 660,
"cds_start": 1809,
"cds_end": null,
"cds_length": 1983,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877643.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1803T>C",
"hgvs_p": "p.Asp601Asp",
"transcript": "ENST00000913369.1",
"protein_id": "ENSP00000583428.1",
"transcript_support_level": null,
"aa_start": 601,
"aa_end": null,
"aa_length": 658,
"cds_start": 1803,
"cds_end": null,
"cds_length": 1977,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913369.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1800T>C",
"hgvs_p": "p.Asp600Asp",
"transcript": "ENST00000877650.1",
"protein_id": "ENSP00000547709.1",
"transcript_support_level": null,
"aa_start": 600,
"aa_end": null,
"aa_length": 657,
"cds_start": 1800,
"cds_end": null,
"cds_length": 1974,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877650.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1770T>C",
"hgvs_p": "p.Asp590Asp",
"transcript": "ENST00000877647.1",
"protein_id": "ENSP00000547706.1",
"transcript_support_level": null,
"aa_start": 590,
"aa_end": null,
"aa_length": 647,
"cds_start": 1770,
"cds_end": null,
"cds_length": 1944,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877647.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1761T>C",
"hgvs_p": "p.Asp587Asp",
"transcript": "ENST00000877642.1",
"protein_id": "ENSP00000547701.1",
"transcript_support_level": null,
"aa_start": 587,
"aa_end": null,
"aa_length": 644,
"cds_start": 1761,
"cds_end": null,
"cds_length": 1935,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877642.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1740T>C",
"hgvs_p": "p.Asp580Asp",
"transcript": "ENST00000877648.1",
"protein_id": "ENSP00000547707.1",
"transcript_support_level": null,
"aa_start": 580,
"aa_end": null,
"aa_length": 637,
"cds_start": 1740,
"cds_end": null,
"cds_length": 1914,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877648.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1692T>C",
"hgvs_p": "p.Asp564Asp",
"transcript": "ENST00000877641.1",
"protein_id": "ENSP00000547700.1",
"transcript_support_level": null,
"aa_start": 564,
"aa_end": null,
"aa_length": 621,
"cds_start": 1692,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877641.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1662T>C",
"hgvs_p": "p.Asp554Asp",
"transcript": "ENST00000965052.1",
"protein_id": "ENSP00000635111.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 611,
"cds_start": 1662,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965052.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1653T>C",
"hgvs_p": "p.Asp551Asp",
"transcript": "ENST00000877646.1",
"protein_id": "ENSP00000547705.1",
"transcript_support_level": null,
"aa_start": 551,
"aa_end": null,
"aa_length": 608,
"cds_start": 1653,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877646.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1599T>C",
"hgvs_p": "p.Asp533Asp",
"transcript": "ENST00000965053.1",
"protein_id": "ENSP00000635112.1",
"transcript_support_level": null,
"aa_start": 533,
"aa_end": null,
"aa_length": 590,
"cds_start": 1599,
"cds_end": null,
"cds_length": 1773,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965053.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1890T>C",
"hgvs_p": "p.Asp630Asp",
"transcript": "XM_047420384.1",
"protein_id": "XP_047276340.1",
"transcript_support_level": null,
"aa_start": 630,
"aa_end": null,
"aa_length": 687,
"cds_start": 1890,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047420384.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1809T>C",
"hgvs_p": "p.Asp603Asp",
"transcript": "XM_047420387.1",
"protein_id": "XP_047276343.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 660,
"cds_start": 1809,
"cds_end": null,
"cds_length": 1983,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047420387.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1761T>C",
"hgvs_p": "p.Asp587Asp",
"transcript": "XM_047420388.1",
"protein_id": "XP_047276344.1",
"transcript_support_level": null,
"aa_start": 587,
"aa_end": null,
"aa_length": 644,
"cds_start": 1761,
"cds_end": null,
"cds_length": 1935,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047420388.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRCH4",
"gene_hgnc_id": 6691,
"hgvs_c": "c.1704T>C",
"hgvs_p": "p.Asp568Asp",
"transcript": "XM_047420389.1",
"protein_id": "XP_047276345.1",
"transcript_support_level": null,
"aa_start": 568,
"aa_end": null,
"aa_length": 625,
"cds_start": 1704,
"cds_end": null,
"cds_length": 1878,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
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},
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}
],
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}