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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-128455825-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=128455825&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 128455825,
      "ref": "C",
      "alt": "G",
      "effect": "upstream_gene_variant",
      "transcript": "ENST00000257696.5",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HILPDA",
          "gene_hgnc_id": 28859,
          "hgvs_c": "c.-267C>G",
          "hgvs_p": null,
          "transcript": "NM_013332.4",
          "protein_id": "NP_037464.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 63,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 192,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1364,
          "mane_select": "ENST00000257696.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HILPDA",
          "gene_hgnc_id": 28859,
          "hgvs_c": "c.-267C>G",
          "hgvs_p": null,
          "transcript": "ENST00000257696.5",
          "protein_id": "ENSP00000257696.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 63,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 192,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1364,
          "mane_select": "NM_013332.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HILPDA",
          "gene_hgnc_id": 28859,
          "hgvs_c": "c.-153C>G",
          "hgvs_p": null,
          "transcript": "NM_001098786.2",
          "protein_id": "NP_001092256.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 63,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 192,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1250,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HILPDA",
          "gene_hgnc_id": 28859,
          "hgvs_c": "c.-153C>G",
          "hgvs_p": null,
          "transcript": "ENST00000435296.2",
          "protein_id": "ENSP00000388871.2",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 63,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 192,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 785,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000273184",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-15C>G",
          "hgvs_p": null,
          "transcript": "ENST00000462662.1",
          "protein_id": null,
          "transcript_support_level": 4,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 707,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HILPDA",
          "gene_hgnc_id": 28859,
          "hgvs_c": "n.-78C>G",
          "hgvs_p": null,
          "transcript": "ENST00000481454.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1370,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "HILPDA-AS1",
          "gene_hgnc_id": 55641,
          "hgvs_c": "n.-112C>G",
          "hgvs_p": null,
          "transcript": "ENST00000493710.1",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 662,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-57G>C",
          "hgvs_p": null,
          "transcript": "ENST00000784862.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 747,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-49G>C",
          "hgvs_p": null,
          "transcript": "ENST00000784863.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 947,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-54G>C",
          "hgvs_p": null,
          "transcript": "ENST00000784864.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 647,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-79G>C",
          "hgvs_p": null,
          "transcript": "ENST00000784865.1",
          "protein_id": null,
          "transcript_support_level": null,
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          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 567,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-65G>C",
          "hgvs_p": null,
          "transcript": "ENST00000784866.1",
          "protein_id": null,
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          "cdna_start": null,
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          "cdna_length": 701,
          "mane_select": null,
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        {
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          "canonical": false,
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          "strand": true,
          "consequences": [
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          ],
          "exon_rank": null,
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          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-96G>C",
          "hgvs_p": null,
          "transcript": "ENST00000784867.1",
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          "mane_select": null,
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        },
        {
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          "strand": true,
          "consequences": [
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          ],
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          "intron_rank": null,
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          "gene_symbol": "ENSG00000302195",
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          "hgvs_c": "n.-16G>C",
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          "mane_select": null,
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        },
        {
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          "strand": true,
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          ],
          "exon_rank": null,
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          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-49G>C",
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          "transcript": "ENST00000784869.1",
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          "intron_rank": null,
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          "gene_symbol": "ENSG00000302195",
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          "hgvs_c": "n.-65G>C",
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        },
        {
          "aa_ref": null,
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          "strand": true,
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          ],
          "exon_rank": null,
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          "intron_rank": null,
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          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-66G>C",
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          "transcript": "ENST00000784871.1",
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        },
        {
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          "consequences": [
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          ],
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          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-78G>C",
          "hgvs_p": null,
          "transcript": "ENST00000784872.1",
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        {
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          "gene_symbol": "ENSG00000302195",
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        },
        {
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          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-69G>C",
          "hgvs_p": null,
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        },
        {
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          "protein_coding": false,
          "strand": true,
          "consequences": [
            "upstream_gene_variant"
          ],
          "exon_rank": null,
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          "exon_count": 4,
          "intron_rank": null,
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          "gene_symbol": "ENSG00000302195",
          "gene_hgnc_id": null,
          "hgvs_c": "n.-80G>C",
          "hgvs_p": null,
          "transcript": "ENST00000784875.1",
          "protein_id": null,
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          "cds_start": -4,
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        {
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          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
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      "clinvar_disease": "",
      "clinvar_classification": "",
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}