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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-17879635-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=17879635&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "7",
      "pos": 17879635,
      "ref": "G",
      "alt": "A",
      "effect": "intron_variant",
      "transcript": "ENST00000428135.7",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.*3179C>T",
          "hgvs_p": null,
          "transcript": "ENST00000409604.1",
          "protein_id": "ENSP00000386639.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 189,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 570,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4146,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.441-3845C>T",
          "hgvs_p": null,
          "transcript": "NM_015132.5",
          "protein_id": "NP_055947.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 957,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2874,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6357,
          "mane_select": "ENST00000428135.7",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.441-3845C>T",
          "hgvs_p": null,
          "transcript": "ENST00000428135.7",
          "protein_id": "ENSP00000398789.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 957,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2874,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6357,
          "mane_select": "NM_015132.5",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.441-3845C>T",
          "hgvs_p": null,
          "transcript": "ENST00000611725.4",
          "protein_id": "ENSP00000479044.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 888,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2667,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6817,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.*3179C>T",
          "hgvs_p": null,
          "transcript": "NM_001350870.2",
          "protein_id": "NP_001337799.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 189,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 570,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 4153,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.441-3845C>T",
          "hgvs_p": null,
          "transcript": "NM_001350862.2",
          "protein_id": "NP_001337791.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 968,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2907,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6390,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.201-3845C>T",
          "hgvs_p": null,
          "transcript": "NM_001350863.2",
          "protein_id": "NP_001337792.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 877,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2634,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6350,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.134+1332C>T",
          "hgvs_p": null,
          "transcript": "NM_001350864.2",
          "protein_id": "NP_001337793.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 855,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2568,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 6424,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.-169-3845C>T",
          "hgvs_p": null,
          "transcript": "NM_001350866.2",
          "protein_id": "NP_001337795.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 754,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2265,
          "cdna_start": null,
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          "cdna_length": 6586,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.-169-3845C>T",
          "hgvs_p": null,
          "transcript": "NM_001350867.2",
          "protein_id": "NP_001337796.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 754,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 2265,
          "cdna_start": null,
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          "cdna_length": 6520,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          "exon_count": 16,
          "intron_rank": 5,
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          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.441-3845C>T",
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          "transcript": "NM_001350868.2",
          "protein_id": "NP_001337797.1",
          "transcript_support_level": null,
          "aa_start": null,
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          "aa_length": 538,
          "cds_start": -4,
          "cds_end": null,
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          "cdna_start": null,
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          "cdna_length": 2129,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
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          "strand": false,
          "consequences": [
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          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": 6,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "n.*139-3845C>T",
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          "transcript": "ENST00000409076.6",
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        {
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          "exon_count": 18,
          "intron_rank": 4,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
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          "hgvs_c": "n.*206-3845C>T",
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        {
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          "gene_symbol": "SNX13",
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          "hgvs_c": "n.618-3845C>T",
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          "transcript": "ENST00000482558.5",
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        {
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          "gene_symbol": "SNX13",
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          "gene_symbol": "SNX13",
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        {
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          "gene_symbol": "SNX13",
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          "hgvs_c": "c.441-3845C>T",
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          "transcript": "XM_011515229.3",
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        {
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          ],
          "exon_rank": null,
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          "gene_symbol": "SNX13",
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          "gene_symbol": "SNX13",
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        {
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          ],
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          "exon_count": 22,
          "intron_rank": 1,
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          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.-169-3845C>T",
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          "cdna_length": 5876,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": 5,
          "intron_rank_end": null,
          "gene_symbol": "SNX13",
          "gene_hgnc_id": 21335,
          "hgvs_c": "c.441-3845C>T",
          "hgvs_p": null,
          "transcript": "XM_005249673.6",
          "protein_id": "XP_005249730.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 539,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1620,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2732,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "SNX13",
      "gene_hgnc_id": 21335,
      "dbsnp": "rs4142995",
      "frequency_reference_population": 0.000013155817,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 2,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": 0.0000131558,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": 2,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.8899999856948853,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.89,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.142,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -2,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong",
      "acmg_by_gene": [
        {
          "score": -2,
          "benign_score": 4,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong"
          ],
          "verdict": "Likely_benign",
          "transcript": "ENST00000428135.7",
          "gene_symbol": "SNX13",
          "hgnc_id": 21335,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.441-3845C>T",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}