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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 7-88179029-AG-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=88179029&ref=AG&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "7",
"pos": 88179029,
"ref": "AG",
"alt": "A",
"effect": "frameshift_variant",
"transcript": "ENST00000413139.2",
"consequences": [
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "NM_001324418.2",
"protein_id": "NP_001311347.1",
"transcript_support_level": null,
"aa_start": 799,
"aa_end": null,
"aa_length": 964,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2895,
"cdna_start": 2611,
"cdna_end": null,
"cdna_length": 9508,
"mane_select": "ENST00000413139.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "ENST00000413139.2",
"protein_id": "ENSP00000412085.2",
"transcript_support_level": 5,
"aa_start": 799,
"aa_end": null,
"aa_length": 964,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2895,
"cdna_start": 2611,
"cdna_end": null,
"cdna_length": 9508,
"mane_select": "NM_001324418.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "ENST00000265727.11",
"protein_id": "ENSP00000265727.7",
"transcript_support_level": 1,
"aa_start": 799,
"aa_end": null,
"aa_length": 906,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2721,
"cdna_start": 2475,
"cdna_end": null,
"cdna_length": 2891,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "ENST00000398201.8",
"protein_id": "ENSP00000381260.4",
"transcript_support_level": 1,
"aa_start": 799,
"aa_end": null,
"aa_length": 859,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2580,
"cdna_start": 2515,
"cdna_end": null,
"cdna_length": 2784,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2301-2475delG",
"hgvs_p": null,
"transcript": "ENST00000398209.7",
"protein_id": "ENSP00000381267.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 899,
"cds_start": -4,
"cds_end": null,
"cds_length": 2700,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9144,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 26,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2301-2475delG",
"hgvs_p": null,
"transcript": "ENST00000398204.8",
"protein_id": "ENSP00000381262.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 870,
"cds_start": -4,
"cds_end": null,
"cds_length": 2613,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9334,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2393delG",
"hgvs_p": "p.Ser798fs",
"transcript": "NM_001324419.2",
"protein_id": "NP_001311348.1",
"transcript_support_level": null,
"aa_start": 798,
"aa_end": null,
"aa_length": 963,
"cds_start": 2393,
"cds_end": null,
"cds_length": 2892,
"cdna_start": 2608,
"cdna_end": null,
"cdna_length": 9505,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "NM_001391976.1",
"protein_id": "NP_001378905.1",
"transcript_support_level": null,
"aa_start": 799,
"aa_end": null,
"aa_length": 943,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2832,
"cdna_start": 2611,
"cdna_end": null,
"cdna_length": 9445,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "NM_001324420.2",
"protein_id": "NP_001311349.1",
"transcript_support_level": null,
"aa_start": 799,
"aa_end": null,
"aa_length": 935,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2808,
"cdna_start": 2611,
"cdna_end": null,
"cdna_length": 9421,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "NM_021723.5",
"protein_id": "NP_068369.1",
"transcript_support_level": null,
"aa_start": 799,
"aa_end": null,
"aa_length": 906,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2721,
"cdna_start": 2611,
"cdna_end": null,
"cdna_length": 9334,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "ENST00000683525.1",
"protein_id": "ENSP00000506730.1",
"transcript_support_level": null,
"aa_start": 799,
"aa_end": null,
"aa_length": 905,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2720,
"cdna_start": 2533,
"cdna_end": null,
"cdna_length": 2857,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2393delG",
"hgvs_p": "p.Ser798fs",
"transcript": "NM_001391979.1",
"protein_id": "NP_001378908.1",
"transcript_support_level": null,
"aa_start": 798,
"aa_end": null,
"aa_length": 905,
"cds_start": 2393,
"cds_end": null,
"cds_length": 2718,
"cdna_start": 2608,
"cdna_end": null,
"cdna_length": 9331,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "NM_004194.5",
"protein_id": "NP_004185.1",
"transcript_support_level": null,
"aa_start": 799,
"aa_end": null,
"aa_length": 859,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2580,
"cdna_start": 2611,
"cdna_end": null,
"cdna_length": 2883,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2297delG",
"hgvs_p": "p.Ser766fs",
"transcript": "ENST00000398203.8",
"protein_id": "ENSP00000381261.4",
"transcript_support_level": 5,
"aa_start": 766,
"aa_end": null,
"aa_length": 802,
"cds_start": 2297,
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"cdna_start": 2581,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "S",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.470delG",
"hgvs_p": "p.Ser157fs",
"transcript": "ENST00000426930.5",
"protein_id": "ENSP00000396233.1",
"transcript_support_level": 5,
"aa_start": 157,
"aa_end": null,
"aa_length": 330,
"cds_start": 470,
"cds_end": null,
"cds_length": 993,
"cdna_start": 470,
"cdna_end": null,
"cdna_length": 1259,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2552delG",
"hgvs_p": "p.Ser851fs",
"transcript": "XM_006716028.5",
"protein_id": "XP_006716091.1",
"transcript_support_level": null,
"aa_start": 851,
"aa_end": null,
"aa_length": 1024,
"cds_start": 2552,
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"cdna_start": 2567,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "XM_011516318.3",
"protein_id": "XP_011514620.1",
"transcript_support_level": null,
"aa_start": 799,
"aa_end": null,
"aa_length": 1001,
"cds_start": 2396,
"cds_end": null,
"cds_length": 3006,
"cdna_start": 2611,
"cdna_end": null,
"cdna_length": 9619,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2393delG",
"hgvs_p": "p.Ser798fs",
"transcript": "XM_011516319.4",
"protein_id": "XP_011514621.1",
"transcript_support_level": null,
"aa_start": 798,
"aa_end": null,
"aa_length": 1000,
"cds_start": 2393,
"cds_end": null,
"cds_length": 3003,
"cdna_start": 2608,
"cdna_end": null,
"cdna_length": 9616,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2552delG",
"hgvs_p": "p.Ser851fs",
"transcript": "XM_011516320.4",
"protein_id": "XP_011514622.1",
"transcript_support_level": null,
"aa_start": 851,
"aa_end": null,
"aa_length": 995,
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"cdna_start": 2567,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2552delG",
"hgvs_p": "p.Ser851fs",
"transcript": "XM_011516321.4",
"protein_id": "XP_011514623.1",
"transcript_support_level": null,
"aa_start": 851,
"aa_end": null,
"aa_length": 987,
"cds_start": 2552,
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"cdna_start": 2567,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2552delG",
"hgvs_p": "p.Ser851fs",
"transcript": "XM_006716029.5",
"protein_id": "XP_006716092.1",
"transcript_support_level": null,
"aa_start": 851,
"aa_end": null,
"aa_length": 978,
"cds_start": 2552,
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"cdna_start": 2567,
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"cdna_length": 9166,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2396delG",
"hgvs_p": "p.Ser799fs",
"transcript": "XM_011516322.3",
"protein_id": "XP_011514624.1",
"transcript_support_level": null,
"aa_start": 799,
"aa_end": null,
"aa_length": 972,
"cds_start": 2396,
"cds_end": null,
"cds_length": 2919,
"cdna_start": 2611,
"cdna_end": null,
"cdna_length": 9532,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADAM22",
"gene_hgnc_id": 201,
"hgvs_c": "c.2552delG",
"hgvs_p": "p.Ser851fs",
"transcript": "XM_005250445.5",
"protein_id": "XP_005250502.1",
"transcript_support_level": null,
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