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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 7-900538-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=7&pos=900538&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "ADAP1",
          "hgnc_id": 16486,
          "hgvs_c": "c.760G>A",
          "hgvs_p": "p.Ala254Thr",
          "inheritance_mode": "",
          "pathogenic_score": 2,
          "score": 0,
          "transcript": "NM_001284308.2",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "gene_symbol": "COX19",
          "hgnc_id": 28074,
          "hgvs_c": "n.*470G>A",
          "hgvs_p": null,
          "inheritance_mode": "AR",
          "pathogenic_score": 2,
          "score": 0,
          "transcript": "ENST00000457254.5",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_score": 0,
      "allele_count_reference_population": 37,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.0691,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.54,
      "chr": "7",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.09189087152481079,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "A",
          "aa_start": 243,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2349,
          "cdna_start": 930,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 727,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "NM_006869.4",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.727G>A",
          "hgvs_p": "p.Ala243Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000265846.10",
          "protein_coding": true,
          "protein_id": "NP_006860.2",
          "strand": false,
          "transcript": "NM_006869.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 374,
          "aa_ref": "A",
          "aa_start": 243,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2349,
          "cdna_start": 930,
          "cds_end": null,
          "cds_length": 1125,
          "cds_start": 727,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000265846.10",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.727G>A",
          "hgvs_p": "p.Ala243Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_006869.4",
          "protein_coding": true,
          "protein_id": "ENSP00000265846.5",
          "strand": false,
          "transcript": "ENST00000265846.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 385,
          "aa_ref": "A",
          "aa_start": 254,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2179,
          "cdna_start": 760,
          "cds_end": null,
          "cds_length": 1158,
          "cds_start": 760,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "NM_001284308.2",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.760G>A",
          "hgvs_p": "p.Ala254Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001271237.2",
          "strand": false,
          "transcript": "NM_001284308.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 385,
          "aa_ref": "A",
          "aa_start": 254,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2178,
          "cdna_start": 760,
          "cds_end": null,
          "cds_length": 1158,
          "cds_start": 760,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000539900.5",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.760G>A",
          "hgvs_p": "p.Ala254Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000442682.1",
          "strand": false,
          "transcript": "ENST00000539900.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 380,
          "aa_ref": "A",
          "aa_start": 243,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2354,
          "cdna_start": 920,
          "cds_end": null,
          "cds_length": 1143,
          "cds_start": 727,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000943017.1",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.727G>A",
          "hgvs_p": "p.Ala243Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000613076.1",
          "strand": false,
          "transcript": "ENST00000943017.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 380,
          "aa_ref": "A",
          "aa_start": 243,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2326,
          "cdna_start": 892,
          "cds_end": null,
          "cds_length": 1143,
          "cds_start": 727,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000943018.1",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.727G>A",
          "hgvs_p": "p.Ala243Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000613077.1",
          "strand": false,
          "transcript": "ENST00000943018.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 373,
          "aa_ref": "A",
          "aa_start": 242,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2360,
          "cdna_start": 944,
          "cds_end": null,
          "cds_length": 1122,
          "cds_start": 724,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000649206.1",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.724G>A",
          "hgvs_p": "p.Ala242Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000497220.1",
          "strand": false,
          "transcript": "ENST00000649206.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "A",
          "aa_start": 225,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2085,
          "cdna_start": 675,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 673,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000446141.5",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.673G>A",
          "hgvs_p": "p.Ala225Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000414436.1",
          "strand": false,
          "transcript": "ENST00000446141.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "A",
          "aa_start": 225,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2293,
          "cdna_start": 878,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 673,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000943015.1",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.673G>A",
          "hgvs_p": "p.Ala225Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000613074.1",
          "strand": false,
          "transcript": "ENST00000943015.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 356,
          "aa_ref": "A",
          "aa_start": 225,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2287,
          "cdna_start": 869,
          "cds_end": null,
          "cds_length": 1071,
          "cds_start": 673,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000943016.1",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.673G>A",
          "hgvs_p": "p.Ala225Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000613075.1",
          "strand": false,
          "transcript": "ENST00000943016.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 353,
          "aa_ref": "A",
          "aa_start": 243,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2296,
          "cdna_start": 945,
          "cds_end": null,
          "cds_length": 1062,
          "cds_start": 727,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000943014.1",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.727G>A",
          "hgvs_p": "p.Ala243Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000613073.1",
          "strand": false,
          "transcript": "ENST00000943014.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 302,
          "aa_ref": "A",
          "aa_start": 171,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2119,
          "cdna_start": 700,
          "cds_end": null,
          "cds_length": 909,
          "cds_start": 511,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "NM_001284309.2",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.511G>A",
          "hgvs_p": "p.Ala171Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001271238.2",
          "strand": false,
          "transcript": "NM_001284309.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 302,
          "aa_ref": "A",
          "aa_start": 171,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2374,
          "cdna_start": 955,
          "cds_end": null,
          "cds_length": 909,
          "cds_start": 511,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_001284310.2",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.511G>A",
          "hgvs_p": "p.Ala171Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001271239.2",
          "strand": false,
          "transcript": "NM_001284310.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 302,
          "aa_ref": "A",
          "aa_start": 171,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2093,
          "cdna_start": 675,
          "cds_end": null,
          "cds_length": 909,
          "cds_start": 511,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000449296.6",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.511G>A",
          "hgvs_p": "p.Ala171Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000407267.2",
          "strand": false,
          "transcript": "ENST00000449296.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 302,
          "aa_ref": "A",
          "aa_start": 171,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2118,
          "cdna_start": 700,
          "cds_end": null,
          "cds_length": 909,
          "cds_start": 511,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000611167.4",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.511G>A",
          "hgvs_p": "p.Ala171Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000481154.1",
          "strand": false,
          "transcript": "ENST00000611167.4",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 279,
          "aa_ref": "A",
          "aa_start": 148,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1935,
          "cdna_start": 516,
          "cds_end": null,
          "cds_length": 840,
          "cds_start": 442,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "NM_001284311.2",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.442G>A",
          "hgvs_p": "p.Ala148Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001271240.2",
          "strand": false,
          "transcript": "NM_001284311.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 279,
          "aa_ref": "A",
          "aa_start": 148,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1946,
          "cdna_start": 528,
          "cds_end": null,
          "cds_length": 840,
          "cds_start": 442,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000617043.4",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.442G>A",
          "hgvs_p": "p.Ala148Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000478011.1",
          "strand": false,
          "transcript": "ENST00000617043.4",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 272,
          "aa_ref": "A",
          "aa_start": 141,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1919,
          "cdna_start": 505,
          "cds_end": null,
          "cds_length": 819,
          "cds_start": 421,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000876359.1",
          "gene_hgnc_id": 16486,
          "gene_symbol": "ADAP1",
          "hgvs_c": "c.421G>A",
          "hgvs_p": "p.Ala141Thr",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546418.1",
          "strand": false,
          "transcript": "ENST00000876359.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "T",
          "aa_end": null,
          "aa_length": 245,
          "aa_ref": "A",
          "aa_start": 114,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 742,
          "cdna_start": 340,
          "cds_end": null,
          "cds_length": 738,
          "cds_start": 340,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.