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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-141150965-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=141150965&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 141150965,
"ref": "C",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000519811.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND3",
"gene_hgnc_id": 29134,
"hgvs_c": "c.855+12C>A",
"hgvs_p": null,
"transcript": "NM_001352890.3",
"protein_id": "NP_001339819.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1278,
"cds_start": -4,
"cds_end": null,
"cds_length": 3837,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5527,
"mane_select": "ENST00000519811.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND3",
"gene_hgnc_id": 29134,
"hgvs_c": "c.855+12C>A",
"hgvs_p": null,
"transcript": "ENST00000519811.6",
"protein_id": "ENSP00000428714.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1278,
"cds_start": -4,
"cds_end": null,
"cds_length": 3837,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5527,
"mane_select": "NM_001352890.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "DENND3",
"gene_hgnc_id": 29134,
"hgvs_c": "c.615+12C>A",
"hgvs_p": null,
"transcript": "ENST00000424248.2",
"protein_id": "ENSP00000410594.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1146,
"cds_start": -4,
"cds_end": null,
"cds_length": 3441,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4740,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND3",
"gene_hgnc_id": 29134,
"hgvs_c": "c.855+12C>A",
"hgvs_p": null,
"transcript": "NM_001362798.2",
"protein_id": "NP_001349727.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1296,
"cds_start": -4,
"cds_end": null,
"cds_length": 3891,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6896,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND3",
"gene_hgnc_id": 29134,
"hgvs_c": "c.654+12C>A",
"hgvs_p": null,
"transcript": "NM_014957.5",
"protein_id": "NP_055772.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1211,
"cds_start": -4,
"cds_end": null,
"cds_length": 3636,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5478,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND3",
"gene_hgnc_id": 29134,
"hgvs_c": "c.783+12C>A",
"hgvs_p": null,
"transcript": "ENST00000518668.5",
"protein_id": "ENSP00000428276.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1202,
"cds_start": -4,
"cds_end": null,
"cds_length": 3609,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5185,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND3",
"gene_hgnc_id": 29134,
"hgvs_c": "c.615+12C>A",
"hgvs_p": null,
"transcript": "ENST00000262585.6",
"protein_id": "ENSP00000262585.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1198,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 5438,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "DENND3",
"gene_hgnc_id": 29134,
"hgvs_c": "c.621+12C>A",
"hgvs_p": null,
"transcript": "ENST00000520986.5",
"protein_id": "ENSP00000429780.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 279,
"cds_start": -4,
"cds_end": null,
"cds_length": 840,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 899,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "DENND3",
"gene_hgnc_id": 29134,
"hgvs_c": "n.974+12C>A",
"hgvs_p": null,
"transcript": "NR_148197.3",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
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"cdna_length": 5942,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 6,
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"gene_symbol": "DENND3",
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"hgvs_c": "c.855+12C>A",
"hgvs_p": null,
"transcript": "XM_011516933.3",
"protein_id": "XP_011515235.2",
"transcript_support_level": null,
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"cds_start": -4,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 21,
"intron_rank": 6,
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"gene_symbol": "DENND3",
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"hgvs_c": "c.855+12C>A",
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"transcript": "XM_005250840.6",
"protein_id": "XP_005250897.3",
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},
{
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],
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},
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],
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},
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],
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],
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},
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],
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],
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"transcript": "XM_047421594.1",
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],
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"gene_symbol": "DENND3",
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"hgvs_c": "c.621+12C>A",
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},
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],
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"gene_symbol": "DENND3",
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}