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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-1907598-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=1907598&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 1907598,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000349830.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.1968-1697C>T",
"hgvs_p": null,
"transcript": "NM_014629.4",
"protein_id": "NP_055444.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1344,
"cds_start": -4,
"cds_end": null,
"cds_length": 4035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5648,
"mane_select": "ENST00000349830.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.1968-1697C>T",
"hgvs_p": null,
"transcript": "ENST00000349830.8",
"protein_id": "ENSP00000340297.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1344,
"cds_start": -4,
"cds_end": null,
"cds_length": 4035,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5648,
"mane_select": "NM_014629.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.2040-1697C>T",
"hgvs_p": null,
"transcript": "ENST00000518288.5",
"protein_id": "ENSP00000431012.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1368,
"cds_start": -4,
"cds_end": null,
"cds_length": 4107,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5648,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.1854-1697C>T",
"hgvs_p": null,
"transcript": "ENST00000520359.5",
"protein_id": "ENSP00000427909.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1306,
"cds_start": -4,
"cds_end": null,
"cds_length": 3921,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5472,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.987-1697C>T",
"hgvs_p": null,
"transcript": "ENST00000522435.5",
"protein_id": "ENSP00000427768.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 988,
"cds_start": -4,
"cds_end": null,
"cds_length": 2967,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4343,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "n.1692-1697C>T",
"hgvs_p": null,
"transcript": "ENST00000523711.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3468,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "KBTBD11-OT1",
"gene_hgnc_id": null,
"hgvs_c": "n.*1922-1697C>T",
"hgvs_p": null,
"transcript": "ENST00000635855.1",
"protein_id": "ENSP00000489726.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
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"cdna_length": 6169,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.2043-1697C>T",
"hgvs_p": null,
"transcript": "ENST00000398564.5",
"protein_id": "ENSP00000381571.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1369,
"cds_start": -4,
"cds_end": null,
"cds_length": 4110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5480,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.1971-1697C>T",
"hgvs_p": null,
"transcript": "NM_001438091.1",
"protein_id": "NP_001425020.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1345,
"cds_start": -4,
"cds_end": null,
"cds_length": 4038,
"cdna_start": null,
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"cdna_length": 5651,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 30,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.1968-1697C>T",
"hgvs_p": null,
"transcript": "NM_001308153.3",
"protein_id": "NP_001295082.2",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 28,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.1854-1697C>T",
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"transcript": "NM_001308152.2",
"protein_id": "NP_001295081.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "ARHGEF10",
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"transcript": "NM_001438092.1",
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},
{
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],
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"gene_symbol": "ARHGEF10",
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"hgvs_c": "c.1851-1697C>T",
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"transcript": "NM_001438093.1",
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},
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],
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"gene_symbol": "ARHGEF10",
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"hgvs_c": "c.1854-1697C>T",
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},
{
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],
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"gene_symbol": "ARHGEF10",
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"transcript": "ENST00000524212.1",
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},
{
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],
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"gene_symbol": "KBTBD11-OT1",
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"transcript": "ENST00000635773.1",
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},
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],
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"gene_symbol": "ARHGEF10",
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"hgvs_c": "c.2055-1697C>T",
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"transcript": "XM_024447335.2",
"protein_id": "XP_024303103.1",
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},
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],
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"gene_symbol": "ARHGEF10",
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"hgvs_c": "c.2043-1697C>T",
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"transcript": "XM_017014003.2",
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},
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"gene_symbol": "ARHGEF10",
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],
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"gene_symbol": "ARHGEF10",
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},
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],
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},
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],
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"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.1854-1697C>T",
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"transcript": "XM_047422454.1",
"protein_id": "XP_047278410.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 16,
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"gene_symbol": "ARHGEF10",
"gene_hgnc_id": 14103,
"hgvs_c": "c.1851-1697C>T",
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"transcript": "XM_047422456.1",
"protein_id": "XP_047278412.1",
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}