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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-47972876-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=47972876&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 47972876,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_005914.4",
"consequences": [
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1948T>C",
"hgvs_p": "p.Leu650Leu",
"transcript": "NM_182746.3",
"protein_id": "NP_877423.1",
"transcript_support_level": null,
"aa_start": 650,
"aa_end": null,
"aa_length": 863,
"cds_start": 1948,
"cds_end": null,
"cds_length": 2592,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000649973.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_182746.3"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1948T>C",
"hgvs_p": "p.Leu650Leu",
"transcript": "ENST00000649973.1",
"protein_id": "ENSP00000496964.1",
"transcript_support_level": null,
"aa_start": 650,
"aa_end": null,
"aa_length": 863,
"cds_start": 1948,
"cds_end": null,
"cds_length": 2592,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_182746.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000649973.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1948T>C",
"hgvs_p": "p.Leu650Leu",
"transcript": "ENST00000262105.6",
"protein_id": "ENSP00000262105.2",
"transcript_support_level": 1,
"aa_start": 650,
"aa_end": null,
"aa_length": 863,
"cds_start": 1948,
"cds_end": null,
"cds_length": 2592,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000262105.6"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.2071T>C",
"hgvs_p": "p.Leu691Leu",
"transcript": "ENST00000649838.1",
"protein_id": "ENSP00000497648.1",
"transcript_support_level": null,
"aa_start": 691,
"aa_end": null,
"aa_length": 904,
"cds_start": 2071,
"cds_end": null,
"cds_length": 2715,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000649838.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.2071T>C",
"hgvs_p": "p.Leu691Leu",
"transcript": "ENST00000936720.1",
"protein_id": "ENSP00000606779.1",
"transcript_support_level": null,
"aa_start": 691,
"aa_end": null,
"aa_length": 904,
"cds_start": 2071,
"cds_end": null,
"cds_length": 2715,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936720.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1972T>C",
"hgvs_p": "p.Leu658Leu",
"transcript": "ENST00000936718.1",
"protein_id": "ENSP00000606777.1",
"transcript_support_level": null,
"aa_start": 658,
"aa_end": null,
"aa_length": 871,
"cds_start": 1972,
"cds_end": null,
"cds_length": 2616,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936718.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1966T>C",
"hgvs_p": "p.Leu656Leu",
"transcript": "ENST00000884674.1",
"protein_id": "ENSP00000554733.1",
"transcript_support_level": null,
"aa_start": 656,
"aa_end": null,
"aa_length": 869,
"cds_start": 1966,
"cds_end": null,
"cds_length": 2610,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884674.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1966T>C",
"hgvs_p": "p.Leu656Leu",
"transcript": "ENST00000936717.1",
"protein_id": "ENSP00000606776.1",
"transcript_support_level": null,
"aa_start": 656,
"aa_end": null,
"aa_length": 869,
"cds_start": 1966,
"cds_end": null,
"cds_length": 2610,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936717.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1948T>C",
"hgvs_p": "p.Leu650Leu",
"transcript": "NM_005914.4",
"protein_id": "NP_005905.2",
"transcript_support_level": null,
"aa_start": 650,
"aa_end": null,
"aa_length": 863,
"cds_start": 1948,
"cds_end": null,
"cds_length": 2592,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005914.4"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1933T>C",
"hgvs_p": "p.Leu645Leu",
"transcript": "ENST00000884671.1",
"protein_id": "ENSP00000554730.1",
"transcript_support_level": null,
"aa_start": 645,
"aa_end": null,
"aa_length": 858,
"cds_start": 1933,
"cds_end": null,
"cds_length": 2577,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884671.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1933T>C",
"hgvs_p": "p.Leu645Leu",
"transcript": "ENST00000884672.1",
"protein_id": "ENSP00000554731.1",
"transcript_support_level": null,
"aa_start": 645,
"aa_end": null,
"aa_length": 858,
"cds_start": 1933,
"cds_end": null,
"cds_length": 2577,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884672.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1873T>C",
"hgvs_p": "p.Leu625Leu",
"transcript": "ENST00000936721.1",
"protein_id": "ENSP00000606780.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 838,
"cds_start": 1873,
"cds_end": null,
"cds_length": 2517,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936721.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1852T>C",
"hgvs_p": "p.Leu618Leu",
"transcript": "ENST00000884673.1",
"protein_id": "ENSP00000554732.1",
"transcript_support_level": null,
"aa_start": 618,
"aa_end": null,
"aa_length": 831,
"cds_start": 1852,
"cds_end": null,
"cds_length": 2496,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000884673.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1801T>C",
"hgvs_p": "p.Leu601Leu",
"transcript": "ENST00000936722.1",
"protein_id": "ENSP00000606781.1",
"transcript_support_level": null,
"aa_start": 601,
"aa_end": null,
"aa_length": 814,
"cds_start": 1801,
"cds_end": null,
"cds_length": 2445,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936722.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1798T>C",
"hgvs_p": "p.Leu600Leu",
"transcript": "ENST00000649919.1",
"protein_id": "ENSP00000498202.1",
"transcript_support_level": null,
"aa_start": 600,
"aa_end": null,
"aa_length": 813,
"cds_start": 1798,
"cds_end": null,
"cds_length": 2442,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000649919.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1606T>C",
"hgvs_p": "p.Leu536Leu",
"transcript": "ENST00000650216.1",
"protein_id": "ENSP00000497093.1",
"transcript_support_level": null,
"aa_start": 536,
"aa_end": null,
"aa_length": 749,
"cds_start": 1606,
"cds_end": null,
"cds_length": 2250,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000650216.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1948T>C",
"hgvs_p": "p.Leu650Leu",
"transcript": "ENST00000648407.1",
"protein_id": "ENSP00000497881.1",
"transcript_support_level": null,
"aa_start": 650,
"aa_end": null,
"aa_length": 742,
"cds_start": 1948,
"cds_end": null,
"cds_length": 2229,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000648407.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1510T>C",
"hgvs_p": "p.Leu504Leu",
"transcript": "ENST00000936719.1",
"protein_id": "ENSP00000606778.1",
"transcript_support_level": null,
"aa_start": 504,
"aa_end": null,
"aa_length": 717,
"cds_start": 1510,
"cds_end": null,
"cds_length": 2154,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936719.1"
},
{
"aa_ref": "L",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1105T>C",
"hgvs_p": "p.Leu369Leu",
"transcript": "ENST00000520637.2",
"protein_id": "ENSP00000427875.2",
"transcript_support_level": 2,
"aa_start": 369,
"aa_end": null,
"aa_length": 582,
"cds_start": 1105,
"cds_end": null,
"cds_length": 1749,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000520637.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "c.1175-3810T>C",
"hgvs_p": null,
"transcript": "ENST00000697122.1",
"protein_id": "ENSP00000513122.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 394,
"cds_start": null,
"cds_end": null,
"cds_length": 1185,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000697122.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "n.1681T>C",
"hgvs_p": null,
"transcript": "ENST00000519470.2",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000519470.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MCM4",
"gene_hgnc_id": 6947,
"hgvs_c": "n.165T>C",
"hgvs_p": null,
"transcript": "ENST00000523853.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
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"splice_prediction_selected": "Benign",
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}
],
"message": null
}