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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-7331836-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=7331836&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 7331836,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000606573.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.704-6421G>A",
"hgvs_p": null,
"transcript": "ENST00000606573.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2630,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.610-6638G>A",
"hgvs_p": null,
"transcript": "ENST00000529456.2",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1433,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.596-6638G>A",
"hgvs_p": null,
"transcript": "ENST00000653873.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2508,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.269-6638G>A",
"hgvs_p": null,
"transcript": "ENST00000656213.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4029,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.171-6638G>A",
"hgvs_p": null,
"transcript": "ENST00000656567.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3774,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.609-6638G>A",
"hgvs_p": null,
"transcript": "ENST00000663272.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4370,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.614-6638G>A",
"hgvs_p": null,
"transcript": "ENST00000664195.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 4238,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.700-6638G>A",
"hgvs_p": null,
"transcript": "ENST00000665607.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4299,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.313-6638G>A",
"hgvs_p": null,
"transcript": "ENST00000670717.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2188,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
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"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.565-6638G>A",
"hgvs_p": null,
"transcript": "ENST00000820789.1",
"protein_id": null,
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 3,
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"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.192+17247G>A",
"hgvs_p": null,
"transcript": "ENST00000820790.1",
"protein_id": null,
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"aa_start": null,
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"feature": null
},
{
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"consequences": [
"intron_variant"
],
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"exon_count": 8,
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"gene_symbol": "FAM66B",
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"hgvs_c": "n.181-6638G>A",
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"transcript": "ENST00000820791.1",
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},
{
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],
"exon_rank": null,
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"exon_count": 6,
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"gene_symbol": "FAM66B",
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"hgvs_c": "n.139-6638G>A",
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"transcript": "ENST00000820792.1",
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},
{
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],
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"gene_symbol": "FAM66B",
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},
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],
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},
{
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"consequences": [
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],
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"gene_symbol": "FAM66B",
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"hgvs_c": "n.609-6421G>A",
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},
{
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],
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],
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},
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],
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"exon_count": 8,
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"gene_symbol": "FAM66B",
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"hgvs_c": "n.232-6638G>A",
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"transcript": "ENST00000820798.1",
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},
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],
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],
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},
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],
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},
{
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"strand": false,
"consequences": [
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],
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"exon_count": 9,
"intron_rank": 3,
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"gene_symbol": "FAM66B",
"gene_hgnc_id": 28890,
"hgvs_c": "n.182-6638G>A",
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"protein_id": null,
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},
{
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"strand": false,
"consequences": [
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],
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"exon_count": 5,
"intron_rank": 2,
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"gene_symbol": "FAM66B",
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