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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-108901478-G-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=108901478&ref=G&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "9",
      "pos": 108901478,
      "ref": "G",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_003640.5",
      "consequences": [
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys",
          "transcript": "NM_003640.5",
          "protein_id": "NP_003631.2",
          "transcript_support_level": null,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 1332,
          "cds_start": 1961,
          "cds_end": null,
          "cds_length": 3999,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000374647.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_003640.5"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys",
          "transcript": "ENST00000374647.10",
          "protein_id": "ENSP00000363779.5",
          "transcript_support_level": 1,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 1332,
          "cds_start": 1961,
          "cds_end": null,
          "cds_length": 3999,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_003640.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000374647.10"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.914C>A",
          "hgvs_p": "p.Thr305Lys",
          "transcript": "ENST00000537196.1",
          "protein_id": "ENSP00000439367.1",
          "transcript_support_level": 1,
          "aa_start": 305,
          "aa_end": null,
          "aa_length": 983,
          "cds_start": 914,
          "cds_end": null,
          "cds_length": 2952,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000537196.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "n.*571C>A",
          "hgvs_p": null,
          "transcript": "ENST00000495759.6",
          "protein_id": "ENSP00000433514.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000495759.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "n.*571C>A",
          "hgvs_p": null,
          "transcript": "ENST00000495759.6",
          "protein_id": "ENSP00000433514.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000495759.6"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys",
          "transcript": "ENST00000675825.1",
          "protein_id": "ENSP00000502632.1",
          "transcript_support_level": null,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 1346,
          "cds_start": 1961,
          "cds_end": null,
          "cds_length": 4041,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000675825.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys",
          "transcript": "ENST00000675052.1",
          "protein_id": "ENSP00000502664.1",
          "transcript_support_level": null,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 1343,
          "cds_start": 1961,
          "cds_end": null,
          "cds_length": 4032,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000675052.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys",
          "transcript": "ENST00000675406.1",
          "protein_id": "ENSP00000501893.1",
          "transcript_support_level": null,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 1332,
          "cds_start": 1961,
          "cds_end": null,
          "cds_length": 3999,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000675406.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys",
          "transcript": "ENST00000861104.1",
          "protein_id": "ENSP00000531163.1",
          "transcript_support_level": null,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 1332,
          "cds_start": 1961,
          "cds_end": null,
          "cds_length": 3999,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000861104.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys",
          "transcript": "ENST00000933697.1",
          "protein_id": "ENSP00000603756.1",
          "transcript_support_level": null,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 1332,
          "cds_start": 1961,
          "cds_end": null,
          "cds_length": 3999,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000933697.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1907C>A",
          "hgvs_p": "p.Thr636Lys",
          "transcript": "ENST00000933696.1",
          "protein_id": "ENSP00000603755.1",
          "transcript_support_level": null,
          "aa_start": 636,
          "aa_end": null,
          "aa_length": 1314,
          "cds_start": 1907,
          "cds_end": null,
          "cds_length": 3945,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000933696.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1862C>A",
          "hgvs_p": "p.Thr621Lys",
          "transcript": "ENST00000676237.1",
          "protein_id": "ENSP00000501828.1",
          "transcript_support_level": null,
          "aa_start": 621,
          "aa_end": null,
          "aa_length": 1313,
          "cds_start": 1862,
          "cds_end": null,
          "cds_length": 3942,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000676237.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys",
          "transcript": "ENST00000674535.1",
          "protein_id": "ENSP00000502142.1",
          "transcript_support_level": null,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 1302,
          "cds_start": 1961,
          "cds_end": null,
          "cds_length": 3909,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000674535.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1619C>A",
          "hgvs_p": "p.Thr540Lys",
          "transcript": "ENST00000676416.1",
          "protein_id": "ENSP00000501660.1",
          "transcript_support_level": null,
          "aa_start": 540,
          "aa_end": null,
          "aa_length": 1232,
          "cds_start": 1619,
          "cds_end": null,
          "cds_length": 3699,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1619C>A",
          "hgvs_p": "p.Thr540Lys",
          "transcript": "NM_001318360.2",
          "protein_id": "NP_001305289.1",
          "transcript_support_level": null,
          "aa_start": 540,
          "aa_end": null,
          "aa_length": 1218,
          "cds_start": 1619,
          "cds_end": null,
          "cds_length": 3657,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001318360.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1619C>A",
          "hgvs_p": "p.Thr540Lys",
          "transcript": "ENST00000674938.1",
          "protein_id": "ENSP00000502427.1",
          "transcript_support_level": null,
          "aa_start": 540,
          "aa_end": null,
          "aa_length": 1218,
          "cds_start": 1619,
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          "cds_length": 3657,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000674938.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1619C>A",
          "hgvs_p": "p.Thr540Lys",
          "transcript": "ENST00000674948.1",
          "protein_id": "ENSP00000501602.1",
          "transcript_support_level": null,
          "aa_start": 540,
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          "cds_start": 1619,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000674948.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.914C>A",
          "hgvs_p": "p.Thr305Lys",
          "transcript": "NM_001330749.2",
          "protein_id": "NP_001317678.1",
          "transcript_support_level": null,
          "aa_start": 305,
          "aa_end": null,
          "aa_length": 983,
          "cds_start": 914,
          "cds_end": null,
          "cds_length": 2952,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001330749.2"
        },
        {
          "aa_ref": "T",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys",
          "transcript": "XM_047423991.1",
          "protein_id": "XP_047279947.1",
          "transcript_support_level": null,
          "aa_start": 654,
          "aa_end": null,
          "aa_length": 892,
          "cds_start": 1961,
          "cds_end": null,
          "cds_length": 2679,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047423991.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 34,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ELP1",
          "gene_hgnc_id": 5959,
          "hgvs_c": "n.3768C>A",
          "hgvs_p": null,
          "transcript": "ENST00000674704.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
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        {
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          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000675979.1"
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      ],
      "gene_symbol": "ELP1",
      "gene_hgnc_id": 5959,
      "dbsnp": "rs764320309",
      "frequency_reference_population": 0.000004104512,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 6,
      "gnomad_exomes_af": 0.00000410451,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 6,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.8942853212356567,
      "computational_prediction_selected": "Pathogenic",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.567,
      "revel_prediction": "Uncertain_significance",
      "alphamissense_score": 0.9639,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": 0.21,
      "bayesdelnoaf_prediction": "Pathogenic",
      "phylop100way_score": 8.639,
      "phylop100way_prediction": "Pathogenic",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 2,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PP3_Moderate",
      "acmg_by_gene": [
        {
          "score": 2,
          "benign_score": 0,
          "pathogenic_score": 2,
          "criteria": [
            "PP3_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_003640.5",
          "gene_symbol": "ELP1",
          "hgnc_id": 5959,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR,AD",
          "hgvs_c": "c.1961C>A",
          "hgvs_p": "p.Thr654Lys"
        }
      ],
      "clinvar_disease": "Familial dysautonomia,not provided",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "Familial dysautonomia|not provided",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}