← Back to variant description

GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-114407949-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=114407949&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "9",
      "pos": 114407949,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant,splice_region_variant",
      "transcript": "ENST00000362057.4",
      "consequences": [
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1696G>A",
          "hgvs_p": "p.Val566Met",
          "transcript": "NM_015404.4",
          "protein_id": "NP_056219.3",
          "transcript_support_level": null,
          "aa_start": 566,
          "aa_end": null,
          "aa_length": 907,
          "cds_start": 1696,
          "cds_end": null,
          "cds_length": 2724,
          "cdna_start": 2368,
          "cdna_end": null,
          "cdna_length": 4070,
          "mane_select": "ENST00000362057.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1696G>A",
          "hgvs_p": "p.Val566Met",
          "transcript": "ENST00000362057.4",
          "protein_id": "ENSP00000354623.3",
          "transcript_support_level": 1,
          "aa_start": 566,
          "aa_end": null,
          "aa_length": 907,
          "cds_start": 1696,
          "cds_end": null,
          "cds_length": 2724,
          "cdna_start": 2368,
          "cdna_end": null,
          "cdna_length": 4070,
          "mane_select": "NM_015404.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.547G>A",
          "hgvs_p": "p.Val183Met",
          "transcript": "ENST00000265134.10",
          "protein_id": "ENSP00000265134.6",
          "transcript_support_level": 1,
          "aa_start": 183,
          "aa_end": null,
          "aa_length": 524,
          "cds_start": 547,
          "cds_end": null,
          "cds_length": 1575,
          "cdna_start": 1145,
          "cdna_end": null,
          "cdna_length": 2847,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1696G>A",
          "hgvs_p": "p.Val566Met",
          "transcript": "NM_001173425.2",
          "protein_id": "NP_001166896.1",
          "transcript_support_level": null,
          "aa_start": 566,
          "aa_end": null,
          "aa_length": 906,
          "cds_start": 1696,
          "cds_end": null,
          "cds_length": 2721,
          "cdna_start": 2368,
          "cdna_end": null,
          "cdna_length": 4067,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1486G>A",
          "hgvs_p": "p.Val496Met",
          "transcript": "ENST00000674036.9",
          "protein_id": "ENSP00000501297.5",
          "transcript_support_level": null,
          "aa_start": 496,
          "aa_end": null,
          "aa_length": 837,
          "cds_start": 1486,
          "cds_end": null,
          "cds_length": 2514,
          "cdna_start": 1486,
          "cdna_end": null,
          "cdna_length": 3190,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.643G>A",
          "hgvs_p": "p.Val215Met",
          "transcript": "NM_001346890.1",
          "protein_id": "NP_001333819.1",
          "transcript_support_level": null,
          "aa_start": 215,
          "aa_end": null,
          "aa_length": 556,
          "cds_start": 643,
          "cds_end": null,
          "cds_length": 1671,
          "cdna_start": 1674,
          "cdna_end": null,
          "cdna_length": 3375,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.547G>A",
          "hgvs_p": "p.Val183Met",
          "transcript": "NM_001083885.3",
          "protein_id": "NP_001077354.2",
          "transcript_support_level": null,
          "aa_start": 183,
          "aa_end": null,
          "aa_length": 524,
          "cds_start": 547,
          "cds_end": null,
          "cds_length": 1575,
          "cdna_start": 1187,
          "cdna_end": null,
          "cdna_length": 2889,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 14,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1729G>A",
          "hgvs_p": "p.Val577Met",
          "transcript": "XM_011518485.2",
          "protein_id": "XP_011516787.1",
          "transcript_support_level": null,
          "aa_start": 577,
          "aa_end": null,
          "aa_length": 918,
          "cds_start": 1729,
          "cds_end": null,
          "cds_length": 2757,
          "cdna_start": 2258,
          "cdna_end": null,
          "cdna_length": 3960,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1729G>A",
          "hgvs_p": "p.Val577Met",
          "transcript": "XM_011518486.3",
          "protein_id": "XP_011516788.1",
          "transcript_support_level": null,
          "aa_start": 577,
          "aa_end": null,
          "aa_length": 917,
          "cds_start": 1729,
          "cds_end": null,
          "cds_length": 2754,
          "cdna_start": 2401,
          "cdna_end": null,
          "cdna_length": 4100,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1696G>A",
          "hgvs_p": "p.Val566Met",
          "transcript": "XM_047423161.1",
          "protein_id": "XP_047279117.1",
          "transcript_support_level": null,
          "aa_start": 566,
          "aa_end": null,
          "aa_length": 907,
          "cds_start": 1696,
          "cds_end": null,
          "cds_length": 2724,
          "cdna_start": 2225,
          "cdna_end": null,
          "cdna_length": 3927,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1696G>A",
          "hgvs_p": "p.Val566Met",
          "transcript": "XM_047423163.1",
          "protein_id": "XP_047279119.1",
          "transcript_support_level": null,
          "aa_start": 566,
          "aa_end": null,
          "aa_length": 906,
          "cds_start": 1696,
          "cds_end": null,
          "cds_length": 2721,
          "cdna_start": 2225,
          "cdna_end": null,
          "cdna_length": 3924,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1603G>A",
          "hgvs_p": "p.Val535Met",
          "transcript": "XM_011518487.3",
          "protein_id": "XP_011516789.1",
          "transcript_support_level": null,
          "aa_start": 535,
          "aa_end": null,
          "aa_length": 876,
          "cds_start": 1603,
          "cds_end": null,
          "cds_length": 2631,
          "cdna_start": 2275,
          "cdna_end": null,
          "cdna_length": 3977,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1570G>A",
          "hgvs_p": "p.Val524Met",
          "transcript": "XM_047423164.1",
          "protein_id": "XP_047279120.1",
          "transcript_support_level": null,
          "aa_start": 524,
          "aa_end": null,
          "aa_length": 865,
          "cds_start": 1570,
          "cds_end": null,
          "cds_length": 2598,
          "cdna_start": 2099,
          "cdna_end": null,
          "cdna_length": 3801,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1570G>A",
          "hgvs_p": "p.Val524Met",
          "transcript": "XM_047423165.1",
          "protein_id": "XP_047279121.1",
          "transcript_support_level": null,
          "aa_start": 524,
          "aa_end": null,
          "aa_length": 864,
          "cds_start": 1570,
          "cds_end": null,
          "cds_length": 2595,
          "cdna_start": 2099,
          "cdna_end": null,
          "cdna_length": 3798,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1486G>A",
          "hgvs_p": "p.Val496Met",
          "transcript": "XM_047423166.1",
          "protein_id": "XP_047279122.1",
          "transcript_support_level": null,
          "aa_start": 496,
          "aa_end": null,
          "aa_length": 837,
          "cds_start": 1486,
          "cds_end": null,
          "cds_length": 2514,
          "cdna_start": 2015,
          "cdna_end": null,
          "cdna_length": 3717,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1486G>A",
          "hgvs_p": "p.Val496Met",
          "transcript": "XM_047423167.1",
          "protein_id": "XP_047279123.1",
          "transcript_support_level": null,
          "aa_start": 496,
          "aa_end": null,
          "aa_length": 836,
          "cds_start": 1486,
          "cds_end": null,
          "cds_length": 2511,
          "cdna_start": 2158,
          "cdna_end": null,
          "cdna_length": 3857,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1360G>A",
          "hgvs_p": "p.Val454Met",
          "transcript": "XM_047423168.1",
          "protein_id": "XP_047279124.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 795,
          "cds_start": 1360,
          "cds_end": null,
          "cds_length": 2388,
          "cdna_start": 1889,
          "cdna_end": null,
          "cdna_length": 3591,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1360G>A",
          "hgvs_p": "p.Val454Met",
          "transcript": "XM_047423169.1",
          "protein_id": "XP_047279125.1",
          "transcript_support_level": null,
          "aa_start": 454,
          "aa_end": null,
          "aa_length": 794,
          "cds_start": 1360,
          "cds_end": null,
          "cds_length": 2385,
          "cdna_start": 2032,
          "cdna_end": null,
          "cdna_length": 3731,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1925G>A",
          "hgvs_p": "p.Arg642His",
          "transcript": "XM_047423170.1",
          "protein_id": "XP_047279126.1",
          "transcript_support_level": null,
          "aa_start": 642,
          "aa_end": null,
          "aa_length": 643,
          "cds_start": 1925,
          "cds_end": null,
          "cds_length": 1932,
          "cdna_start": 2597,
          "cdna_end": null,
          "cdna_length": 3137,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.1823G>A",
          "hgvs_p": "p.Arg608His",
          "transcript": "XM_047423171.1",
          "protein_id": "XP_047279127.1",
          "transcript_support_level": null,
          "aa_start": 608,
          "aa_end": null,
          "aa_length": 609,
          "cds_start": 1823,
          "cds_end": null,
          "cds_length": 1830,
          "cdna_start": 2495,
          "cdna_end": null,
          "cdna_length": 3035,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "n.2420G>A",
          "hgvs_p": null,
          "transcript": "ENST00000673811.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2674,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "n.1577G>A",
          "hgvs_p": null,
          "transcript": "ENST00000674048.1",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3278,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "n.2596G>A",
          "hgvs_p": null,
          "transcript": "XR_929750.4",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2596,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "n.2470G>A",
          "hgvs_p": null,
          "transcript": "XR_929757.3",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2492,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "WHRN",
          "gene_hgnc_id": 16361,
          "hgvs_c": "c.*81G>A",
          "hgvs_p": null,
          "transcript": "XM_011518492.3",
          "protein_id": "XP_011516794.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 571,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": 1716,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2454,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        }
      ],
      "gene_symbol": "WHRN",
      "gene_hgnc_id": 16361,
      "dbsnp": "rs189654215",
      "frequency_reference_population": 0.000006875825,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 11,
      "gnomad_exomes_af": 0.00000483551,
      "gnomad_genomes_af": 0.000026284,
      "gnomad_exomes_ac": 7,
      "gnomad_genomes_ac": 4,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.15723749995231628,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.026000000536441803,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "dbscSNV1_RF",
      "revel_score": 0.052,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.1051,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.66,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 1.647,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": 0.000438580140704177,
      "dbscsnv_ada_prediction": "Benign",
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": 0,
          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000362057.4",
          "gene_symbol": "WHRN",
          "hgnc_id": 16361,
          "effects": [
            "missense_variant",
            "splice_region_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.1696G>A",
          "hgvs_p": "p.Val566Met"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}