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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-115067708-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=115067708&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 115067708,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000350763.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TNC",
"gene_hgnc_id": 5318,
"hgvs_c": "c.3215-2789G>A",
"hgvs_p": null,
"transcript": "NM_002160.4",
"protein_id": "NP_002151.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2201,
"cds_start": -4,
"cds_end": null,
"cds_length": 6606,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8500,
"mane_select": "ENST00000350763.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TNC",
"gene_hgnc_id": 5318,
"hgvs_c": "c.3215-2789G>A",
"hgvs_p": null,
"transcript": "ENST00000350763.9",
"protein_id": "ENSP00000265131.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 2201,
"cds_start": -4,
"cds_end": null,
"cds_length": 6606,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8500,
"mane_select": "NM_002160.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TNC",
"gene_hgnc_id": 5318,
"hgvs_c": "c.3215-2789G>A",
"hgvs_p": null,
"transcript": "ENST00000423613.6",
"protein_id": "ENSP00000411406.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1928,
"cds_start": -4,
"cds_end": null,
"cds_length": 5787,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6281,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TNC",
"gene_hgnc_id": 5318,
"hgvs_c": "c.3214+5895G>A",
"hgvs_p": null,
"transcript": "ENST00000542877.6",
"protein_id": "ENSP00000442242.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1838,
"cds_start": -4,
"cds_end": null,
"cds_length": 5517,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5879,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TNC",
"gene_hgnc_id": 5318,
"hgvs_c": "c.3215-2789G>A",
"hgvs_p": null,
"transcript": "NM_001439065.1",
"protein_id": "NP_001425994.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2384,
"cds_start": -4,
"cds_end": null,
"cds_length": 7155,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 9049,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "TNC",
"gene_hgnc_id": 5318,
"hgvs_c": "c.3215-2789G>A",
"hgvs_p": null,
"transcript": "NM_001439066.1",
"protein_id": "NP_001425995.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2384,
"cds_start": -4,
"cds_end": null,
"cds_length": 7155,
"cdna_start": null,
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"cdna_length": 9153,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "TNC",
"gene_hgnc_id": 5318,
"hgvs_c": "c.3215-2789G>A",
"hgvs_p": null,
"transcript": "NM_001439067.1",
"protein_id": "NP_001425996.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2384,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 9279,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TNC",
"gene_hgnc_id": 5318,
"hgvs_c": "c.3215-2789G>A",
"hgvs_p": null,
"transcript": "NM_001439068.1",
"protein_id": "NP_001425997.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2293,
"cds_start": -4,
"cds_end": null,
"cds_length": 6882,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8776,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "TNC",
"gene_hgnc_id": 5318,
"hgvs_c": "c.3215-2789G>A",
"hgvs_p": null,
"transcript": "NM_001439069.1",
"protein_id": "NP_001425998.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2293,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
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"intron_rank": 11,
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"gene_symbol": "TNC",
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"hgvs_c": "c.3215-2789G>A",
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"transcript": "NM_001439070.1",
"protein_id": "NP_001425999.1",
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 10,
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"gene_symbol": "TNC",
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"hgvs_c": "c.3215-2789G>A",
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"transcript": "NM_001439071.1",
"protein_id": "NP_001426000.1",
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},
{
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],
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},
{
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],
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"gene_symbol": "TNC",
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},
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],
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"gene_symbol": "TNC",
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],
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},
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],
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},
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],
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"transcript": "NM_001439078.1",
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},
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],
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],
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"gene_symbol": "TNC",
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},
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],
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"gene_symbol": "TNC",
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"protein_id": "NP_001397920.1",
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{
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}
],
"message": null
}