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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-121154742-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=121154742&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 121154742,
"ref": "T",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000373855.7",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 44,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4194T>A",
"hgvs_p": "p.Val1398Val",
"transcript": "NM_007018.6",
"protein_id": "NP_008949.4",
"transcript_support_level": null,
"aa_start": 1398,
"aa_end": null,
"aa_length": 2325,
"cds_start": 4194,
"cds_end": null,
"cds_length": 6978,
"cdna_start": 4511,
"cdna_end": null,
"cdna_length": 7719,
"mane_select": "ENST00000373855.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 44,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4194T>A",
"hgvs_p": "p.Val1398Val",
"transcript": "ENST00000373855.7",
"protein_id": "ENSP00000362962.1",
"transcript_support_level": 5,
"aa_start": 1398,
"aa_end": null,
"aa_length": 2325,
"cds_start": 4194,
"cds_end": null,
"cds_length": 6978,
"cdna_start": 4511,
"cdna_end": null,
"cdna_length": 7719,
"mane_select": "NM_007018.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4194T>A",
"hgvs_p": "p.Val1398Val",
"transcript": "ENST00000373847.6",
"protein_id": "ENSP00000362953.2",
"transcript_support_level": 1,
"aa_start": 1398,
"aa_end": null,
"aa_length": 1700,
"cds_start": 4194,
"cds_end": null,
"cds_length": 5103,
"cdna_start": 4331,
"cdna_end": null,
"cdna_length": 5449,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "n.673T>A",
"hgvs_p": null,
"transcript": "ENST00000373845.6",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3881,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.2544T>A",
"hgvs_p": "p.Val848Val",
"transcript": "ENST00000686219.1",
"protein_id": "ENSP00000509692.1",
"transcript_support_level": null,
"aa_start": 848,
"aa_end": null,
"aa_length": 1806,
"cds_start": 2544,
"cds_end": null,
"cds_length": 5421,
"cdna_start": 2544,
"cdna_end": null,
"cdna_length": 5665,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.2544T>A",
"hgvs_p": "p.Val848Val",
"transcript": "ENST00000685839.1",
"protein_id": "ENSP00000509395.1",
"transcript_support_level": null,
"aa_start": 848,
"aa_end": null,
"aa_length": 1790,
"cds_start": 2544,
"cds_end": null,
"cds_length": 5373,
"cdna_start": 2544,
"cdna_end": null,
"cdna_length": 5916,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.2538T>A",
"hgvs_p": "p.Val846Val",
"transcript": "NM_001330762.2",
"protein_id": "NP_001317691.1",
"transcript_support_level": null,
"aa_start": 846,
"aa_end": null,
"aa_length": 1773,
"cds_start": 2538,
"cds_end": null,
"cds_length": 5322,
"cdna_start": 2726,
"cdna_end": null,
"cdna_length": 5934,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.2538T>A",
"hgvs_p": "p.Val846Val",
"transcript": "ENST00000373850.6",
"protein_id": "ENSP00000362956.1",
"transcript_support_level": 2,
"aa_start": 846,
"aa_end": null,
"aa_length": 1773,
"cds_start": 2538,
"cds_end": null,
"cds_length": 5322,
"cdna_start": 2703,
"cdna_end": null,
"cdna_length": 5911,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.2538T>A",
"hgvs_p": "p.Val846Val",
"transcript": "NM_001369892.1",
"protein_id": "NP_001356821.1",
"transcript_support_level": null,
"aa_start": 846,
"aa_end": null,
"aa_length": 1726,
"cds_start": 2538,
"cds_end": null,
"cds_length": 5181,
"cdna_start": 2726,
"cdna_end": null,
"cdna_length": 5793,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4194T>A",
"hgvs_p": "p.Val1398Val",
"transcript": "NM_001369893.1",
"protein_id": "NP_001356822.1",
"transcript_support_level": null,
"aa_start": 1398,
"aa_end": null,
"aa_length": 1700,
"cds_start": 4194,
"cds_end": null,
"cds_length": 5103,
"cdna_start": 4338,
"cdna_end": null,
"cdna_length": 5456,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4251T>A",
"hgvs_p": "p.Val1417Val",
"transcript": "NM_001369894.1",
"protein_id": "NP_001356823.1",
"transcript_support_level": null,
"aa_start": 1417,
"aa_end": null,
"aa_length": 1610,
"cds_start": 4251,
"cds_end": null,
"cds_length": 4833,
"cdna_start": 4395,
"cdna_end": null,
"cdna_length": 5462,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.3693T>A",
"hgvs_p": "p.Val1231Val",
"transcript": "NM_001369895.1",
"protein_id": "NP_001356824.1",
"transcript_support_level": null,
"aa_start": 1231,
"aa_end": null,
"aa_length": 1533,
"cds_start": 3693,
"cds_end": null,
"cds_length": 4602,
"cdna_start": 4380,
"cdna_end": null,
"cdna_length": 5498,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 46,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4251T>A",
"hgvs_p": "p.Val1417Val",
"transcript": "XM_047422667.1",
"protein_id": "XP_047278623.1",
"transcript_support_level": null,
"aa_start": 1417,
"aa_end": null,
"aa_length": 2359,
"cds_start": 4251,
"cds_end": null,
"cds_length": 7080,
"cdna_start": 4568,
"cdna_end": null,
"cdna_length": 7821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 45,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4251T>A",
"hgvs_p": "p.Val1417Val",
"transcript": "XM_047422668.1",
"protein_id": "XP_047278624.1",
"transcript_support_level": null,
"aa_start": 1417,
"aa_end": null,
"aa_length": 2359,
"cds_start": 4251,
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"cdna_start": 4395,
"cdna_end": null,
"cdna_length": 7648,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 45,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4251T>A",
"hgvs_p": "p.Val1417Val",
"transcript": "XM_047422669.1",
"protein_id": "XP_047278625.1",
"transcript_support_level": null,
"aa_start": 1417,
"aa_end": null,
"aa_length": 2344,
"cds_start": 4251,
"cds_end": null,
"cds_length": 7035,
"cdna_start": 4568,
"cdna_end": null,
"cdna_length": 7776,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 45,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4194T>A",
"hgvs_p": "p.Val1398Val",
"transcript": "XM_011518166.3",
"protein_id": "XP_011516468.1",
"transcript_support_level": null,
"aa_start": 1398,
"aa_end": null,
"aa_length": 2340,
"cds_start": 4194,
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"cdna_start": 4511,
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"cdna_length": 7764,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 44,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4194T>A",
"hgvs_p": "p.Val1398Val",
"transcript": "XM_011518167.1",
"protein_id": "XP_011516469.1",
"transcript_support_level": null,
"aa_start": 1398,
"aa_end": null,
"aa_length": 2340,
"cds_start": 4194,
"cds_end": null,
"cds_length": 7023,
"cdna_start": 4338,
"cdna_end": null,
"cdna_length": 7591,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 46,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4176T>A",
"hgvs_p": "p.Val1392Val",
"transcript": "XM_047422670.1",
"protein_id": "XP_047278626.1",
"transcript_support_level": null,
"aa_start": 1392,
"aa_end": null,
"aa_length": 2334,
"cds_start": 4176,
"cds_end": null,
"cds_length": 7005,
"cdna_start": 4493,
"cdna_end": null,
"cdna_length": 7746,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 43,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4194T>A",
"hgvs_p": "p.Val1398Val",
"transcript": "XM_047422682.1",
"protein_id": "XP_047278638.1",
"transcript_support_level": null,
"aa_start": 1398,
"aa_end": null,
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"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 46,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4251T>A",
"hgvs_p": "p.Val1417Val",
"transcript": "XM_047422671.1",
"protein_id": "XP_047278627.1",
"transcript_support_level": null,
"aa_start": 1417,
"aa_end": null,
"aa_length": 2321,
"cds_start": 4251,
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"cdna_start": 4568,
"cdna_end": null,
"cdna_length": 7707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 45,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4119T>A",
"hgvs_p": "p.Val1373Val",
"transcript": "XM_011518168.3",
"protein_id": "XP_011516470.1",
"transcript_support_level": null,
"aa_start": 1373,
"aa_end": null,
"aa_length": 2315,
"cds_start": 4119,
"cds_end": null,
"cds_length": 6948,
"cdna_start": 4436,
"cdna_end": null,
"cdna_length": 7689,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 44,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.4119T>A",
"hgvs_p": "p.Val1373Val",
"transcript": "XM_047422672.1",
"protein_id": "XP_047278628.1",
"transcript_support_level": null,
"aa_start": 1373,
"aa_end": null,
"aa_length": 2315,
"cds_start": 4119,
"cds_end": null,
"cds_length": 6948,
"cdna_start": 4263,
"cdna_end": null,
"cdna_length": 7516,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 45,
"intron_rank": null,
"intron_rank_end": null,
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