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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-128125577-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=128125577&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 128125577,
"ref": "C",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000338961.11",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "c.280-136G>T",
"hgvs_p": null,
"transcript": "NM_025072.7",
"protein_id": "NP_079348.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 377,
"cds_start": -4,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1598,
"mane_select": "ENST00000338961.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "c.280-136G>T",
"hgvs_p": null,
"transcript": "ENST00000338961.11",
"protein_id": "ENSP00000345341.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 377,
"cds_start": -4,
"cds_end": null,
"cds_length": 1134,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1598,
"mane_select": "NM_025072.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "n.1600G>T",
"hgvs_p": null,
"transcript": "ENST00000493205.6",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3473,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "c.280-136G>T",
"hgvs_p": null,
"transcript": "ENST00000678174.1",
"protein_id": "ENSP00000504703.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 369,
"cds_start": -4,
"cds_end": null,
"cds_length": 1110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1554,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "c.280-241G>T",
"hgvs_p": null,
"transcript": "ENST00000449878.1",
"protein_id": "ENSP00000411378.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 264,
"cds_start": -4,
"cds_end": null,
"cds_length": 796,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 803,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "c.-198-136G>T",
"hgvs_p": null,
"transcript": "NM_001256335.2",
"protein_id": "NP_001243264.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 186,
"cds_start": -4,
"cds_end": null,
"cds_length": 561,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1301,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "c.-387-136G>T",
"hgvs_p": null,
"transcript": "NM_198938.3",
"protein_id": "NP_945176.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 186,
"cds_start": -4,
"cds_end": null,
"cds_length": 561,
"cdna_start": null,
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"cdna_length": 1593,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "c.-387-136G>T",
"hgvs_p": null,
"transcript": "ENST00000277462.9",
"protein_id": "ENSP00000277462.5",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 186,
"cds_start": -4,
"cds_end": null,
"cds_length": 561,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1614,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "c.-198-136G>T",
"hgvs_p": null,
"transcript": "ENST00000617202.4",
"protein_id": "ENSP00000482913.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 186,
"cds_start": -4,
"cds_end": null,
"cds_length": 561,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1344,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "c.-294-136G>T",
"hgvs_p": null,
"transcript": "ENST00000677691.1",
"protein_id": "ENSP00000503821.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 186,
"cds_start": -4,
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"cds_length": 561,
"cdna_start": null,
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"cdna_length": 1901,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "n.280-136G>T",
"hgvs_p": null,
"transcript": "ENST00000474124.6",
"protein_id": "ENSP00000503197.1",
"transcript_support_level": 5,
"aa_start": null,
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
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"hgvs_c": "n.284-136G>T",
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"transcript": "ENST00000476655.6",
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},
{
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"consequences": [
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],
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"gene_symbol": "PTGES2",
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},
{
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],
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"hgvs_c": "n.298-136G>T",
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},
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],
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},
{
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],
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"intron_rank": 1,
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"gene_symbol": "PTGES2",
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"hgvs_c": "n.274-136G>T",
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},
{
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],
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},
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],
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"gene_symbol": "PTGES2",
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},
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"strand": false,
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],
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "PTGES2",
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"hgvs_c": "n.295-136G>T",
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],
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],
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},
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],
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"intron_rank": 2,
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"gene_symbol": "PTGES2",
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"hgvs_c": "n.*327-136G>T",
"hgvs_p": null,
"transcript": "ENST00000677980.1",
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"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "PTGES2",
"gene_hgnc_id": 17822,
"hgvs_c": "n.280-136G>T",
"hgvs_p": null,
"transcript": "ENST00000678916.1",
"protein_id": "ENSP00000504746.1",
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},
{
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"consequences": [
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],
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}
],
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}