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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-128908640-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=128908640&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 128908640,
"ref": "T",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "NM_019594.4",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "NM_019594.4",
"protein_id": "NP_062540.2",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000372600.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_019594.4"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000372600.9",
"protein_id": "ENSP00000361682.4",
"transcript_support_level": 1,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_019594.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372600.9"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000372599.7",
"protein_id": "ENSP00000361680.3",
"transcript_support_level": 1,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372599.7"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000927475.1",
"protein_id": "ENSP00000597534.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 838,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2517,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927475.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "NM_001127244.2",
"protein_id": "NP_001120716.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127244.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "NM_001127245.2",
"protein_id": "NP_001120717.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127245.2"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000259324.5",
"protein_id": "ENSP00000259324.5",
"transcript_support_level": 2,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000259324.5"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867202.1",
"protein_id": "ENSP00000537261.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867202.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867203.1",
"protein_id": "ENSP00000537262.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867203.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867204.1",
"protein_id": "ENSP00000537263.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867204.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867205.1",
"protein_id": "ENSP00000537264.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867205.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867206.1",
"protein_id": "ENSP00000537265.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867206.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867207.1",
"protein_id": "ENSP00000537266.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867207.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867208.1",
"protein_id": "ENSP00000537267.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867208.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867209.1",
"protein_id": "ENSP00000537268.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867209.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867210.1",
"protein_id": "ENSP00000537269.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867210.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867211.1",
"protein_id": "ENSP00000537270.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867211.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867212.1",
"protein_id": "ENSP00000537271.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867212.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867213.1",
"protein_id": "ENSP00000537272.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867213.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000867214.1",
"protein_id": "ENSP00000537273.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867214.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000927466.1",
"protein_id": "ENSP00000597525.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
"cds_length": 2433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927466.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC8A",
"gene_hgnc_id": 19027,
"hgvs_c": "c.1476T>A",
"hgvs_p": "p.Arg492Arg",
"transcript": "ENST00000927467.1",
"protein_id": "ENSP00000597526.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 810,
"cds_start": 1476,
"cds_end": null,
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}
],
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}