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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-93308387-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=93308387&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 93308387,
"ref": "G",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000427277.7",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6319G>A",
"hgvs_p": "p.Val2107Ile",
"transcript": "NM_006648.4",
"protein_id": "NP_006639.3",
"transcript_support_level": null,
"aa_start": 2107,
"aa_end": null,
"aa_length": 2217,
"cds_start": 6319,
"cds_end": null,
"cds_length": 6654,
"cdna_start": 6568,
"cdna_end": null,
"cdna_length": 7080,
"mane_select": "ENST00000427277.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6319G>A",
"hgvs_p": "p.Val2107Ile",
"transcript": "ENST00000427277.7",
"protein_id": "ENSP00000411181.4",
"transcript_support_level": 5,
"aa_start": 2107,
"aa_end": null,
"aa_length": 2217,
"cds_start": 6319,
"cds_end": null,
"cds_length": 6654,
"cdna_start": 6568,
"cdna_end": null,
"cdna_length": 7080,
"mane_select": "NM_006648.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6430G>A",
"hgvs_p": "p.Val2144Ile",
"transcript": "ENST00000297954.9",
"protein_id": "ENSP00000297954.4",
"transcript_support_level": 1,
"aa_start": 2144,
"aa_end": null,
"aa_length": 2297,
"cds_start": 6430,
"cds_end": null,
"cds_length": 6894,
"cdna_start": 6696,
"cdna_end": null,
"cdna_length": 8338,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6319G>A",
"hgvs_p": "p.Val2107Ile",
"transcript": "ENST00000432730.6",
"protein_id": "ENSP00000415038.2",
"transcript_support_level": 1,
"aa_start": 2107,
"aa_end": null,
"aa_length": 2224,
"cds_start": 6319,
"cds_end": null,
"cds_length": 6675,
"cdna_start": 6319,
"cdna_end": null,
"cdna_length": 7805,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4792G>A",
"hgvs_p": "p.Val1598Ile",
"transcript": "ENST00000411624.5",
"protein_id": "ENSP00000414622.1",
"transcript_support_level": 1,
"aa_start": 1598,
"aa_end": null,
"aa_length": 1772,
"cds_start": 4792,
"cds_end": null,
"cds_length": 5319,
"cdna_start": 4793,
"cdna_end": null,
"cdna_length": 6679,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6430G>A",
"hgvs_p": "p.Val2144Ile",
"transcript": "NM_001282394.3",
"protein_id": "NP_001269323.1",
"transcript_support_level": null,
"aa_start": 2144,
"aa_end": null,
"aa_length": 2297,
"cds_start": 6430,
"cds_end": null,
"cds_length": 6894,
"cdna_start": 6679,
"cdna_end": null,
"cdna_length": 8324,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6319G>A",
"hgvs_p": "p.Val2107Ile",
"transcript": "ENST00000395477.6",
"protein_id": "ENSP00000378860.2",
"transcript_support_level": 5,
"aa_start": 2107,
"aa_end": null,
"aa_length": 2217,
"cds_start": 6319,
"cds_end": null,
"cds_length": 6654,
"cdna_start": 6319,
"cdna_end": null,
"cdna_length": 6834,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.1738G>A",
"hgvs_p": "p.Val580Ile",
"transcript": "ENST00000453718.2",
"protein_id": "ENSP00000413325.1",
"transcript_support_level": 5,
"aa_start": 580,
"aa_end": null,
"aa_length": 644,
"cds_start": 1738,
"cds_end": null,
"cds_length": 1935,
"cdna_start": 1740,
"cdna_end": null,
"cdna_length": 1937,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6319G>A",
"hgvs_p": "p.Val2107Ile",
"transcript": "XM_005252137.4",
"protein_id": "XP_005252194.1",
"transcript_support_level": null,
"aa_start": 2107,
"aa_end": null,
"aa_length": 2260,
"cds_start": 6319,
"cds_end": null,
"cds_length": 6783,
"cdna_start": 6568,
"cdna_end": null,
"cdna_length": 8213,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6316G>A",
"hgvs_p": "p.Val2106Ile",
"transcript": "XM_017015045.2",
"protein_id": "XP_016870534.1",
"transcript_support_level": null,
"aa_start": 2106,
"aa_end": null,
"aa_length": 2259,
"cds_start": 6316,
"cds_end": null,
"cds_length": 6780,
"cdna_start": 6565,
"cdna_end": null,
"cdna_length": 8210,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6265G>A",
"hgvs_p": "p.Val2089Ile",
"transcript": "XM_017015047.2",
"protein_id": "XP_016870536.1",
"transcript_support_level": null,
"aa_start": 2089,
"aa_end": null,
"aa_length": 2242,
"cds_start": 6265,
"cds_end": null,
"cds_length": 6729,
"cdna_start": 6514,
"cdna_end": null,
"cdna_length": 8159,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6262G>A",
"hgvs_p": "p.Val2088Ile",
"transcript": "XM_017015048.2",
"protein_id": "XP_016870537.1",
"transcript_support_level": null,
"aa_start": 2088,
"aa_end": null,
"aa_length": 2241,
"cds_start": 6262,
"cds_end": null,
"cds_length": 6726,
"cdna_start": 6511,
"cdna_end": null,
"cdna_length": 8156,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6220G>A",
"hgvs_p": "p.Val2074Ile",
"transcript": "XM_017015049.2",
"protein_id": "XP_016870538.1",
"transcript_support_level": null,
"aa_start": 2074,
"aa_end": null,
"aa_length": 2227,
"cds_start": 6220,
"cds_end": null,
"cds_length": 6684,
"cdna_start": 6469,
"cdna_end": null,
"cdna_length": 8114,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6217G>A",
"hgvs_p": "p.Val2073Ile",
"transcript": "XM_017015050.2",
"protein_id": "XP_016870539.1",
"transcript_support_level": null,
"aa_start": 2073,
"aa_end": null,
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"cds_start": 6217,
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"cdna_start": 6466,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6319G>A",
"hgvs_p": "p.Val2107Ile",
"transcript": "XM_005252140.3",
"protein_id": "XP_005252197.1",
"transcript_support_level": null,
"aa_start": 2107,
"aa_end": null,
"aa_length": 2224,
"cds_start": 6319,
"cds_end": null,
"cds_length": 6675,
"cdna_start": 6568,
"cdna_end": null,
"cdna_length": 8058,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6316G>A",
"hgvs_p": "p.Val2106Ile",
"transcript": "XM_047423741.1",
"protein_id": "XP_047279697.1",
"transcript_support_level": null,
"aa_start": 2106,
"aa_end": null,
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"cds_start": 6316,
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"cdna_start": 6565,
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"cdna_length": 7077,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6184G>A",
"hgvs_p": "p.Val2062Ile",
"transcript": "XM_017015051.2",
"protein_id": "XP_016870540.1",
"transcript_support_level": null,
"aa_start": 2062,
"aa_end": null,
"aa_length": 2215,
"cds_start": 6184,
"cds_end": null,
"cds_length": 6648,
"cdna_start": 6433,
"cdna_end": null,
"cdna_length": 8078,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6175G>A",
"hgvs_p": "p.Val2059Ile",
"transcript": "XM_047423742.1",
"protein_id": "XP_047279698.1",
"transcript_support_level": null,
"aa_start": 2059,
"aa_end": null,
"aa_length": 2212,
"cds_start": 6175,
"cds_end": null,
"cds_length": 6639,
"cdna_start": 6424,
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"cdna_length": 8069,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": "I",
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6172G>A",
"hgvs_p": "p.Val2058Ile",
"transcript": "XM_047423743.1",
"protein_id": "XP_047279699.1",
"transcript_support_level": null,
"aa_start": 2058,
"aa_end": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6166G>A",
"hgvs_p": "p.Val2056Ile",
"transcript": "XM_017015052.2",
"protein_id": "XP_016870541.1",
"transcript_support_level": null,
"aa_start": 2056,
"aa_end": null,
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"cds_start": 6166,
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"cdna_start": 6415,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6163G>A",
"hgvs_p": "p.Val2055Ile",
"transcript": "XM_017015053.2",
"protein_id": "XP_016870542.1",
"transcript_support_level": null,
"aa_start": 2055,
"aa_end": null,
"aa_length": 2208,
"cds_start": 6163,
"cds_end": null,
"cds_length": 6627,
"cdna_start": 6412,
"cdna_end": null,
"cdna_length": 8057,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 26,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.6121G>A",
"hgvs_p": "p.Val2041Ile",
"transcript": "XM_047423744.1",
"protein_id": "XP_047279700.1",
"transcript_support_level": null,
"aa_start": 2041,
"aa_end": null,
"aa_length": 2194,
"cds_start": 6121,
"cds_end": null,
"cds_length": 6585,
"cdna_start": 6370,
"cdna_end": null,
"cdna_length": 8015,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
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