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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-94760130-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=94760130&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 94760130,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001193329.3",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001193329.3",
"protein_id": "NP_001180258.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 819,
"cds_start": 347,
"cds_end": null,
"cds_length": 2460,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 3130,
"mane_select": "ENST00000375315.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "ENST00000375315.8",
"protein_id": "ENSP00000364464.2",
"transcript_support_level": 1,
"aa_start": 116,
"aa_end": null,
"aa_length": 819,
"cds_start": 347,
"cds_end": null,
"cds_length": 2460,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 3130,
"mane_select": "NM_001193329.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "ENST00000297979.9",
"protein_id": "ENSP00000297979.5",
"transcript_support_level": 1,
"aa_start": 116,
"aa_end": null,
"aa_length": 720,
"cds_start": 347,
"cds_end": null,
"cds_length": 2163,
"cdna_start": 522,
"cdna_end": null,
"cdna_length": 2820,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386066.1",
"protein_id": "NP_001372995.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 859,
"cds_start": 347,
"cds_end": null,
"cds_length": 2580,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 2985,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386068.1",
"protein_id": "NP_001372997.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 859,
"cds_start": 347,
"cds_end": null,
"cds_length": 2580,
"cdna_start": 716,
"cdna_end": null,
"cdna_length": 3166,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386070.1",
"protein_id": "NP_001372999.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 820,
"cds_start": 347,
"cds_end": null,
"cds_length": 2463,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 2868,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386075.1",
"protein_id": "NP_001373004.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 819,
"cds_start": 347,
"cds_end": null,
"cds_length": 2460,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 4268,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386074.1",
"protein_id": "NP_001373003.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 798,
"cds_start": 347,
"cds_end": null,
"cds_length": 2397,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 4707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386063.2",
"protein_id": "NP_001372992.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 773,
"cds_start": 347,
"cds_end": null,
"cds_length": 2322,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 2992,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386069.1",
"protein_id": "NP_001372998.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 760,
"cds_start": 347,
"cds_end": null,
"cds_length": 2283,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 2688,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386076.1",
"protein_id": "NP_001373005.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 732,
"cds_start": 347,
"cds_end": null,
"cds_length": 2199,
"cdna_start": 535,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "H",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
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"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_032823.6",
"protein_id": "NP_116212.3",
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"aa_start": 116,
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"cds_start": 347,
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"cdna_start": 535,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
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"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386062.2",
"protein_id": "NP_001372991.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 712,
"cds_start": 347,
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"cdna_start": 535,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
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"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386067.1",
"protein_id": "NP_001372996.1",
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},
{
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"protein_coding": true,
"strand": true,
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],
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"exon_count": 8,
"intron_rank": null,
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"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001193331.3",
"protein_id": "NP_001180260.1",
"transcript_support_level": null,
"aa_start": 116,
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"aa_length": 566,
"cds_start": 347,
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"cdna_start": 535,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
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"exon_count": 9,
"intron_rank": null,
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"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386071.1",
"protein_id": "NP_001373000.1",
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},
{
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"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
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"intron_rank": null,
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"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "ENST00000277198.6",
"protein_id": "ENSP00000277198.2",
"transcript_support_level": 2,
"aa_start": 116,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "NM_001386072.1",
"protein_id": "NP_001373001.1",
"transcript_support_level": null,
"aa_start": 116,
"aa_end": null,
"aa_length": 555,
"cds_start": 347,
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"cdna_start": 535,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 2,
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"intron_rank": null,
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"gene_symbol": "AOPEP",
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"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "XM_047423978.1",
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},
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],
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"intron_rank": null,
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"gene_symbol": "AOPEP",
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"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "XM_011519121.4",
"protein_id": "XP_011517423.1",
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},
{
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],
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"gene_symbol": "AOPEP",
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"transcript": "XM_047423979.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
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"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
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"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "XM_047423980.1",
"protein_id": "XP_047279936.1",
"transcript_support_level": null,
"aa_start": 116,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": 2,
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"exon_count": 14,
"intron_rank": null,
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"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.347A>G",
"hgvs_p": "p.His116Arg",
"transcript": "XM_047423981.1",
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}
],
"message": null
}