ADGRF2P
pseudoadhesion G protein-coupled receptor F2, pseudogene, the group of Adhesion G protein-coupled receptors, subfamily F
Gene summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within enamel mineralization; gene expression; and response to pH. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jun 2026]
- GPR111
- ADGRF2
MANE transcript
Inheritance
ClinVar variants
Top phenotype
gnomAD constraint
Max pathogenic AF
Genomic locus
External References & Databases
GenCC Phenotypes & Disease Associations
Curated gene-disease validity assertions and inheritance patterns
No GenCC data available for this gene.
ClinVar Associated Diseases & Phenotypes
Reported disease conditions connected to ADGRF2P variants in ClinVar
No annotated ClinVar phenotypes.
ClinVar Variants & Pathogenicity by Type
Statistics based on transcript . Only rare variants are included.
We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.
Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.
| Effect | PathogenicP | Likely pathogenicLP | VUS | Likely benignLB | BenignB | Sum |
|---|---|---|---|---|---|---|
| synonymous | 0 | |||||
| missense | 0 | |||||
| nonsense | 0 | |||||
| start loss | 0 | |||||
| frameshift | 0 | |||||
| splice donor/acceptor (+/-2bp) | 0 | |||||
| Total | 0 | 0 | 0 | 0 | 0 | 0 |
Transcript Catalog
Annotated transcript isoforms across RefSeq and Ensembl databases
| Transcript ID | Source | Protein ID | Coding Exons | MANE Status |
|---|---|---|---|---|
| No transcripts match your selected source or search query. | ||||
Gene Ontology (GO) Annotations & Pathways
Biological processes, molecular functions, cellular components and pathways
Biological Process
- cell surface receptor signaling pathway
- G protein-coupled receptor signaling pathway
Molecular Function
- G protein-coupled receptor activity
Cellular Component
- integral component of membrane
gnomAD Constraint
Source:
- Gene type
- protein_coding
- Transcript type
- protein_coding
- Transcript
- ENST00000296862
- Coding exons
- 6
- Length
- 41362
- Individuals with no LoFs
- 124360
- Homozygous LoFs
- 2
- Heterozygous LoFs
- 440
- Defined
- 124802
- p
- 0.00177
| Z-Score | Observed | Expected | Observed/Expected | Mutation Rate | Total Possible | |
|---|---|---|---|---|---|---|
| Missense | -0.589 | 394 | 362 | 1.09 | 0.0000170 | 4632 |
| Missense (PolyPhen) | 145 | 130.64 | 1.1099 | 1720 | ||
| Synonymous | -1.16 | 150 | 133 | 1.13 | 0.00000621 | 1424 |
| Loss of Function | -1.68 | 31 | 22.4 | 1.38 | 0.00000114 | 279 |
Population LoF Frequency
| Population | CAF | p-value | Status |
|---|---|---|---|
| African | 0.0024 | 0.0024 | notable |
| Latino/Admixed American | 0.0010 | 0.00099 | notable |
| Ashkenazi Jewish | 0.0023 | 0.0023 | notable |
| East Asian | 0.0087 | 0.0087 | notable |
| Finnish | 0.000046 | 0.000046 | rare |
| European (Non-Finnish) | 0.00073 | 0.00072 | rare |
| South Asian | 0.0034 | 0.0034 | notable |
| Other | 0.0012 | 0.0012 | notable |
dbNSFP Gene Annotations
Source:
- Function
- FUNCTION: Orphan receptor.;
Recessive Scores
- pRec
- 0.0764