RASSF10

Ras association domain family member 10, the group of Ras association domain family

Basic information

Region (hg38): 11:13009316-13012119

Links

ENSG00000189431 ∙ NCBI:644943 ∙ OMIM:614713 ∙ HGNC:33984 ∙ Uniprot:A6NK89 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the RASSF10 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the RASSF10 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			44			44
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	44	0	0

Variants in RASSF10

This is a list of pathogenic ClinVar variants found in the RASSF10 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
11-13009586-T-C		not specified	Uncertain significance (Jun 03, 2022)
11-13009643-T-C		not specified	Uncertain significance (Jan 29, 2025)
11-13009737-C-T		not specified	Uncertain significance (Jul 25, 2023)
11-13009755-G-A		not specified	Uncertain significance (Dec 04, 2024)
11-13009775-C-G		not specified	Uncertain significance (Jan 22, 2025)
11-13009791-A-G		not specified	Uncertain significance (Jan 21, 2025)
11-13009799-G-T		not specified	Uncertain significance (Nov 15, 2024)
11-13009804-C-G		not specified	Uncertain significance (Jan 10, 2025)
11-13009812-T-C		not specified	Uncertain significance (Apr 25, 2022)
11-13009827-T-A		not specified	Uncertain significance (Apr 28, 2022)
11-13009879-G-C		not specified	Uncertain significance (Apr 22, 2022)
11-13009902-G-A		not specified	Uncertain significance (Oct 04, 2024)
11-13009910-C-A		not specified	Uncertain significance (Sep 11, 2024)
11-13009931-G-A		not specified	Uncertain significance (Feb 16, 2023)
11-13009962-T-G		not specified	Uncertain significance (Aug 21, 2023)
11-13009988-G-T		not specified	Uncertain significance (Jan 03, 2024)
11-13009995-C-T		not specified	Uncertain significance (Oct 01, 2024)
11-13009997-C-T		not specified	Uncertain significance (Dec 04, 2024)
11-13010013-G-C		not specified	Uncertain significance (Sep 16, 2021)
11-13010030-G-C		not specified	Uncertain significance (Dec 28, 2024)
11-13010058-C-A		not specified	Uncertain significance (Jun 04, 2024)
11-13010058-C-G		not specified	Uncertain significance (Aug 23, 2021)
11-13010082-C-G		not specified	Uncertain significance (Aug 17, 2021)
11-13010163-C-T		not specified	Uncertain significance (Oct 02, 2023)
11-13010207-T-C		not specified	Uncertain significance (Apr 05, 2023)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

• Function: FUNCTION: Plays an important role in regulating embryonic neurogenesis. {ECO:0000250|UniProtKB:Q8BL43}.

Recessive Scores

• pRec: 0.107

Mouse Genome Informatics

• Gene name: Rassf10

Gene ontology

• Biological process: signal transduction;positive regulation of neurogenesis;positive regulation of neural precursor cell proliferation
• Cellular component: spindle pole;microtubule organizing center;cytosol