ZNF761

zinc finger protein 761, the group of Zinc fingers C2H2-type

Basic information

Region (hg38): 19:53431984-53461862

Links

ENSG00000160336 ∙ NCBI:388561 ∙ ∙ HGNC:23179 ∙ Uniprot:Q86XN6 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ZNF761 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ZNF761 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			13			13
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	13	0	0

Variants in ZNF761

This is a list of pathogenic ClinVar variants found in the ZNF761 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
19-53449539-A-G		not specified	Uncertain significance (Aug 11, 2022)
19-53449543-A-C		not specified	Uncertain significance (Aug 02, 2021)
19-53449575-C-A		not specified	Uncertain significance (Jan 28, 2025)
19-53449597-G-A		not specified	Uncertain significance (Mar 07, 2025)
19-53449617-T-C		not specified	Uncertain significance (Feb 21, 2024)
19-53454676-G-A		not specified	Uncertain significance (Oct 24, 2024)
19-53454782-A-G		not specified	Uncertain significance (Apr 28, 2022)
19-53455066-C-T		not specified	Uncertain significance (Apr 04, 2024)
19-53455094-T-C		not specified	Uncertain significance (Jul 14, 2024)
19-53455343-T-G		not specified	Uncertain significance (Aug 12, 2021)
19-53455369-C-T		not specified	Uncertain significance (May 20, 2024)
19-53455404-A-C		not specified	Uncertain significance (Oct 29, 2024)
19-53455901-C-G		not specified	Uncertain significance (Jan 03, 2024)
19-53455940-A-G		not specified	Uncertain significance (Jan 26, 2023)
19-53456174-G-A		not specified	Uncertain significance (Mar 10, 2025)
19-53456620-C-G		not specified	Uncertain significance (Feb 28, 2023)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

• Function: FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
• Pathway: Gene expression (Transcription);Generic Transcription Pathway;RNA Polymerase II Transcription (Consensus)

Haploinsufficiency Scores

• pHI: 0.0433

Mouse Genome Informatics

• Gene name: Zfp51

Gene ontology

• Biological process: regulation of transcription, DNA-templated
• Cellular component: nucleus
• Molecular function: DNA binding;metal ion binding