NM_007294.4:c.3975G>A

Variant names:

• chr17-43091556-C-T
• rs761424661
• NM_007294.4:c.3975G>A

Variant summary

Our verdict is Benign. The variant received -9 ACMG points: 2P and 11B. PM2 BP4_Moderate BP6_Very_Strong BP7

The NM_007294.4(BRCA1):​c.3975G>A​(p.Arg1325Arg) variant causes a synonymous change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.00000274 in 1,461,876 control chromosomes in the GnomAD database, with no homozygous occurrence. In-silico tool predicts a benign outcome for this variant. Variant has been reported in ClinVar as Likely benign (★★★).

• Frequency:
  • Genomes: not found (cov: 32)
  • Exomes 𝑓: 0.0000027 (0 hom.)
• Consequence: BRCA1 NM_007294.4 synonymous
• Clinical Significance: Likely benign reviewed by expert panel B:6
• Conservation: PhyloP100: -0.306
• Publications: 3 publications found

Genes affected

BRCA1 (HGNC:1100): (BRCA1 DNA repair associated) This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]

BRCA1 Gene-Disease associations (from GenCC):

• breast-ovarian cancer, familial, susceptibility to, 1

  Inheritance: AD Classification: DEFINITIVE, STRONG Submitted by: Ambry Genetics, ClinGen, Labcorp Genetics (formerly Invitae), Genomics England PanelApp
• Fanconi anemia, complementation group S

  Inheritance: AR Classification: DEFINITIVE, STRONG, MODERATE, LIMITED Submitted by: G2P, Labcorp Genetics (formerly Invitae), ClinGen, Ambry Genetics
• pancreatic cancer, susceptibility to, 4

  Inheritance: AD Classification: MODERATE Submitted by: Genomics England PanelApp
• hereditary breast ovarian cancer syndrome

  Inheritance: AD Classification: SUPPORTIVE Submitted by: Orphanet
• Fanconi anemia

  Inheritance: AR Classification: SUPPORTIVE Submitted by: Orphanet

ACMG classification

Our verdict: Benign. The variant received -9 ACMG points.

• PM2: Very rare variant in population databases, with high coverage
• BP4: Computational evidence support a benign effect (REVEL=0.05).
• BP6: Variant 17-43091556-C-T is Benign according to our data. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43091556-C-T is described in CliVar as Likely_benign. Clinvar id is 415574.Status of the report is reviewed_by_expert_panel, 3 stars.
• BP7: Synonymous conserved (PhyloP=-0.306 with no splicing effect.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	MANE	Protein	UniProt
BRCA1	NM_007294.4	c.3975G>A	p.Arg1325Arg	synonymous_variant	Exon 10 of 23	ENST00000357654.9	NP_009225.1

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	TSL	MANE	Protein	Appris	UniProt
BRCA1	ENST00000357654.9	c.3975G>A	p.Arg1325Arg	synonymous_variant	Exon 10 of 23	1	NM_007294.4	ENSP00000350283.3

Frequencies

GnomAD3 genomes Cov.: 32

GnomAD2 exomes AF: 0.00000398 AC: 1 AN: 251272 AF XY: 0.00000736

Gnomad AFR exome AF: 0.00

Gnomad AMR exome AF: 0.00

Gnomad ASJ exome AF: 0.00

Gnomad EAS exome AF: 0.00

Gnomad FIN exome AF: 0.00

Gnomad NFE exome AF: 0.00

Gnomad OTH exome AF: 0.00

GnomAD4 exome AF: 0.00000274 AC: 4 AN: 1461876 Hom.: 0 Cov.: 32 AF XY: 0.00000138 AC XY: 1 AN XY: 727238

African (AFR) AF: 0.00 AC: 0 AN: 33480

American (AMR) AF: 0.00 AC: 0 AN: 44724

Ashkenazi Jewish (ASJ) AF: 0.00 AC: 0 AN: 26134

East Asian (EAS) AF: 0.0000504 AC: 2 AN: 39696

South Asian (SAS) AF: 0.0000116 AC: 1 AN: 86258

European-Finnish (FIN) AF: 0.00 AC: 0 AN: 53414

Middle Eastern (MID) AF: 0.00 AC: 0 AN: 5768

European-Non Finnish (NFE) AF: 8.99e-7 AC: 1 AN: 1112006

Other (OTH) AF: 0.00 AC: 0 AN: 60396

GnomAD4 genome Cov.: 32

Alfa AF: 0.0000267 Hom.: 0

Bravo AF: 0.0000113

ClinVar

Significance: Likely benign

Submissions summary: Benign:6

Revision: reviewed by expert panel

Submissions by phenotype

not provided Benign:2

May 15, 2015

GeneDx

Significance: Benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

This variant is associated with the following publications: (PMID: 29020732, 30287823) -

Dec 04, 2020

Quest Diagnostics Nichols Institute San Juan Capistrano

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

not specified Benign:1

Oct 21, 2020

Women's Health and Genetics/Laboratory Corporation of America, LabCorp

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Breast-ovarian cancer, familial, susceptibility to, 1 Benign:1

Jun 29, 2017

Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA)

Significance: Likely benign

Review Status: reviewed by expert panel

Collection Method: curation

Synonymous substitution variant, with low bioinformatic likelihood to result in a splicing aberration (Splicing prior probability 0.02; http://priors.hci.utah.edu/PRIORS/). -

Hereditary cancer-predisposing syndrome Benign:1

Sep 16, 2016

Ambry Genetics

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity. -

Hereditary breast ovarian cancer syndrome Benign:1

Oct 03, 2024

Labcorp Genetics (formerly Invitae), Labcorp

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.76
CADD	Benign	2.7
DANN	Benign	0.44
PhyloP100		-0.31
PromoterAI		0.013	Neutral
RBP_binding_hub_radar		0.0
RBP_regulation_power_radar		1.1

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs761424661; hg19: chr17-41243573;