rs28897697

Variant names:

• chr17-43063369-C-A
• rs28897697
• NM_007294.4:c.5157G>T

Your query was ambiguous. Multiple possible variants found:

• chr17-43063369-C-A
• chr17-43063369-C-G
• chr17-43063369-C-T

Variant summary

Our verdict is Benign. The variant received -10 ACMG points: 0P and 10B. BP4_Moderate BP6_Very_Strong

The NM_007294.4(BRCA1):​c.5157G>T​(p.Val1719Val) variant causes a synonymous change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.0000552 in 1,611,588 control chromosomes in the GnomAD database, with no homozygous occurrence. In-silico tool predicts a benign outcome for this variant. Variant has been reported in ClinVar as Likely benign (★★★). Synonymous variant affecting the same amino acid position (i.e. V1719V) has been classified as Uncertain significance.

• Frequency:
  • Genomes: 𝑓 0.000039 (0 hom., cov: 32)
  • Exomes 𝑓: 0.000057 (0 hom.)
• Consequence: BRCA1 NM_007294.4 synonymous
• Clinical Significance: Likely benign reviewed by expert panel B:11
• Conservation: PhyloP100: -0.386
• Publications: 6 publications found

Genes affected

BRCA1 (HGNC:1100): (BRCA1 DNA repair associated) This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]

BRCA1 Gene-Disease associations (from GenCC):

• breast-ovarian cancer, familial, susceptibility to, 1

  Inheritance: AD Classification: DEFINITIVE, STRONG Submitted by: Ambry Genetics, ClinGen, Labcorp Genetics (formerly Invitae), Genomics England PanelApp
• Fanconi anemia, complementation group S

  Inheritance: AR Classification: DEFINITIVE, STRONG, MODERATE, LIMITED Submitted by: G2P, Labcorp Genetics (formerly Invitae), ClinGen, Ambry Genetics
• pancreatic cancer, susceptibility to, 4

  Inheritance: AD Classification: MODERATE Submitted by: Genomics England PanelApp
• hereditary breast ovarian cancer syndrome

  Inheritance: AD Classification: SUPPORTIVE Submitted by: Orphanet
• Fanconi anemia

  Inheritance: AR Classification: SUPPORTIVE Submitted by: Orphanet

ACMG classification

Our verdict: Benign. The variant received -10 ACMG points.

• BP4: Computational evidence support a benign effect (BayesDel_noAF=-0.29).
• BP6: Variant 17-43063369-C-A is Benign according to our data. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43063369-C-A is described in CliVar as Likely_benign. Clinvar id is 184120.Status of the report is reviewed_by_expert_panel, 3 stars.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	MANE	Protein	UniProt
BRCA1	NM_007294.4	c.5157G>T	p.Val1719Val	synonymous_variant	Exon 18 of 23	ENST00000357654.9	NP_009225.1

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	TSL	MANE	Protein	Appris	UniProt
BRCA1	ENST00000357654.9	c.5157G>T	p.Val1719Val	synonymous_variant	Exon 18 of 23	1	NM_007294.4	ENSP00000350283.3

Frequencies

GnomAD3 genomes AF: 0.0000394 AC: 6 AN: 152154 Hom.: 0 Cov.: 32

Gnomad AFR AF: 0.00

Gnomad AMI AF: 0.00

Gnomad AMR AF: 0.00

Gnomad ASJ AF: 0.00

Gnomad EAS AF: 0.00

Gnomad SAS AF: 0.00

Gnomad FIN AF: 0.00

Gnomad MID AF: 0.00

Gnomad NFE AF: 0.0000882

Gnomad OTH AF: 0.00

GnomAD2 exomes AF: 0.0000159 AC: 4 AN: 250910 AF XY: 0.0000147

Gnomad AFR exome AF: 0.000123

Gnomad AMR exome AF: 0.00

Gnomad ASJ exome AF: 0.00

Gnomad EAS exome AF: 0.00

Gnomad FIN exome AF: 0.00

Gnomad NFE exome AF: 0.0000176

Gnomad OTH exome AF: 0.00

GnomAD4 exome AF: 0.0000569 AC: 83 AN: 1459316 Hom.: 0 Cov.: 30 AF XY: 0.0000537 AC XY: 39 AN XY: 726216

African (AFR) AF: 0.0000598 AC: 2 AN: 33424

American (AMR) AF: 0.00 AC: 0 AN: 44710

Ashkenazi Jewish (ASJ) AF: 0.00 AC: 0 AN: 26128

East Asian (EAS) AF: 0.00 AC: 0 AN: 39684

South Asian (SAS) AF: 0.00 AC: 0 AN: 86190

European-Finnish (FIN) AF: 0.00 AC: 0 AN: 53146

Middle Eastern (MID) AF: 0.00 AC: 0 AN: 5760

European-Non Finnish (NFE) AF: 0.0000694 AC: 77 AN: 1109952

Other (OTH) AF: 0.0000663 AC: 4 AN: 60322

GnomAD4 genome AF: 0.0000394 AC: 6 AN: 152272 Hom.: 0 Cov.: 32 AF XY: 0.0000134 AC XY: 1 AN XY: 74464

African (AFR) AF: 0.00 AC: 0 AN: 41558

American (AMR) AF: 0.00 AC: 0 AN: 15286

Ashkenazi Jewish (ASJ) AF: 0.00 AC: 0 AN: 3472

East Asian (EAS) AF: 0.00 AC: 0 AN: 5192

South Asian (SAS) AF: 0.00 AC: 0 AN: 4826

European-Finnish (FIN) AF: 0.00 AC: 0 AN: 10610

Middle Eastern (MID) AF: 0.00 AC: 0 AN: 294

European-Non Finnish (NFE) AF: 0.0000882 AC: 6 AN: 68008

Other (OTH) AF: 0.00 AC: 0 AN: 2114

Alfa AF: 0.0000440 Hom.: 0

Bravo AF: 0.0000302

Asia WGS AF: 0.000289 AC: 1 AN: 3478

EpiCase AF: 0.0000545

EpiControl AF: 0.0000593

ClinVar

Significance: Likely benign

Submissions summary: Benign:11

Revision: reviewed by expert panel

Submissions by phenotype

not specified Benign:2

Jul 22, 2019

Women's Health and Genetics/Laboratory Corporation of America, LabCorp

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Nov 20, 2018

ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Breast-ovarian cancer, familial, susceptibility to, 1 Benign:2

Jun 29, 2017

Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA)

Significance: Likely benign

Review Status: reviewed by expert panel

Collection Method: curation

Synonymous substitution variant, with low bioinformatic likelihood to result in a splicing aberration (Splicing prior probability 0.02; http://priors.hci.utah.edu/PRIORS/). -

May 20, 2016

Counsyl

Significance: Likely benign

Review Status: no assertion criteria provided

Collection Method: clinical testing

This submission and the accompanying classification are no longer maintained by the submitter. For more information on current observations and classification, please contact variantquestions@myriad.com. -

not provided Benign:2

Mar 03, 2015

GeneDx

Significance: Benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

This variant is associated with the following publications: (PMID: 30209399) -

Jul 04, 2023

Quest Diagnostics Nichols Institute San Juan Capistrano

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Hereditary cancer-predisposing syndrome Benign:2

Nov 20, 2014

Ambry Genetics

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity. -

May 09, 2017

Color Diagnostics, LLC DBA Color Health

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Breast and/or ovarian cancer Benign:1

Sep 29, 2022

CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

BRCA1-related cancer predisposition Benign:1

Aug 30, 2024

All of Us Research Program, National Institutes of Health

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Hereditary breast ovarian cancer syndrome Benign:1

Jan 06, 2025

Labcorp Genetics (formerly Invitae), Labcorp

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.29
CADD	Benign	6.5
DANN	Benign	0.61
PhyloP100		-0.39

Splicing

Name	Calibrated prediction	Score	Prediction
Splicevardb		1.0
SpliceAI score (max)		0.010		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs28897697; hg19: chr17-41215386;