FOLH1B
pseudofolate hydrolase 1B (pseudogene), the group of M28 metallopeptidases
Gene summary
Enables Ac-Asp-Glu binding activity and metallocarboxypeptidase activity. Involved in obsolete glutamate biosynthetic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jun 2026]
- FOLH2
- FOLHP
MANE transcript
Inheritance
ClinVar variants
Top phenotype
Max pathogenic AF
Genomic locus
External References & Databases
GenCC Phenotypes & Disease Associations
Curated gene-disease validity assertions and inheritance patterns
No GenCC data available for this gene.
ClinVar Associated Diseases & Phenotypes
Reported disease conditions connected to FOLH1B variants in ClinVar
ClinVar Variants & Pathogenicity by Type
Statistics based on transcript . Only rare variants are included.
We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.
Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.
| Effect | PathogenicP | Likely pathogenicLP | VUS | Likely benignLB | BenignB | Sum |
|---|---|---|---|---|---|---|
| synonymous | 0 | |||||
| missense | 0 | |||||
| nonsense | 0 | |||||
| start loss | 0 | |||||
| frameshift | 0 | |||||
| splice donor/acceptor (+/-2bp) | 0 | |||||
| Total | 0 | 0 | 0 | 0 | 0 | 0 |
Transcript Catalog
Annotated transcript isoforms across RefSeq and Ensembl databases
| Transcript ID | Source | Protein ID | Coding Exons | MANE Status |
|---|---|---|---|---|
| No transcripts match your selected source or search query. | ||||
Gene Ontology (GO) Annotations & Pathways
Biological processes, molecular functions, cellular components and pathways
Pathways ConsensusPathDB
- Metabolism of amino acids and derivatives
- Metabolism
- Amino acid synthesis and interconversion (transamination)
Biological Process
- proteolysis
- cellular amino acid biosynthetic process
- C-terminal protein deglutamylation
Molecular Function
- metallocarboxypeptidase activity
- dipeptidase activity
- metal ion binding
Cellular Component
- cytoplasm
- plasma membrane
- extracellular exosome
dbNSFP Gene Annotations
Source:
- Function
- FUNCTION: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. {ECO:0000250}.;