GeneBe Hub

A unified repository for genetic variant annotations

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What is GeneBe Hub?

GeneBe Hub is an open repository for genetic variant databases. Like PyPI for Python packages or Docker Hub for container images, it serves as a repository for annotations. You can add your own databases—private or public—or use existing ones prepared by other users.

How to use databases?

Databases can be used to annotate your VCF files with the GeneBeClient. Additional tools, including Python Pandas integration, will be released soon.

Featured Databases

ClinVar

A comprehensive database of clinically relevant variants. Evergreen.

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gnomAD

A large-scale population database for allele frequencies.

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SpliceAI

State of the Art Splicing Effect Predictor

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dbSNP

A collection of single nucleotide polymorphisms (SNPs).

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Why GeneBe Hub?

GeneBe Hub is designed to make genetic variant annotations easier and more accessible. It's a place, where genetic databases are:

Easy to find

A single place for all the databases you need.

Easy to parse

A standardized format—no more dealing with custom TSV files with unusual headers.

Easy to use

If your variants are in VCF format, annotation is as simple as running one command.

Easy to keep evergreen

A new version of a database is available? Just pull the latest version and annotate again.

Need Help?

Explore our guides and documentation to get started.