TAAR9

trace amine associated receptor 9, the group of Trace amine receptors

Basic information

Region (hg38): 6:132538276-132539336

Previous symbols: [ "TRAR3" ]

Links

ENSG00000237110 ∙ NCBI:134860 ∙ OMIM:608282 ∙ HGNC:20977 ∙ Uniprot:Q96RI9 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TAAR9 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TAAR9 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous				3		3
missense			23	1		24
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	23	4	0

Variants in TAAR9

This is a list of pathogenic ClinVar variants found in the TAAR9 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
6-132538372-C-G		not specified	Uncertain significance (Aug 02, 2021)
6-132538400-C-T			Likely benign (Oct 01, 2022)
6-132538454-T-G		not specified	Uncertain significance (Apr 01, 2024)
6-132538461-C-T		not specified	Uncertain significance (Jan 16, 2024)
6-132538464-C-G		not specified	Uncertain significance (Dec 20, 2021)
6-132538491-A-G		not specified	Uncertain significance (May 23, 2023)
6-132538495-T-A		not specified	Uncertain significance (Aug 12, 2021)
6-132538504-C-T		not specified	Uncertain significance (Dec 19, 2022)
6-132538522-A-T		not specified	Uncertain significance (May 20, 2024)
6-132538535-A-T			Likely benign (Mar 01, 2023)
6-132538672-T-C		not specified	Uncertain significance (May 20, 2024)
6-132538695-G-C		not specified	Uncertain significance (Apr 22, 2022)
6-132538780-G-A		not specified	Uncertain significance (Dec 08, 2023)
6-132538855-G-T		not specified	Uncertain significance (Mar 06, 2023)
6-132538900-T-C		not specified	Uncertain significance (Jan 16, 2024)
6-132538903-T-C		not specified	Uncertain significance (Feb 28, 2024)
6-132538939-A-G		not specified	Uncertain significance (Apr 17, 2023)
6-132539013-T-G		not specified	Uncertain significance (Oct 12, 2022)
6-132539014-C-T		not specified	Uncertain significance (Dec 26, 2023)
6-132539079-A-G		not specified	Likely benign (Nov 15, 2021)
6-132539082-G-A		not specified	Uncertain significance (Dec 21, 2022)
6-132539167-A-G		not specified	Uncertain significance (Jul 25, 2023)
6-132539194-A-G		not specified	Uncertain significance (Dec 22, 2023)
6-132539204-T-C			Likely benign (Mar 01, 2023)
6-132539205-A-C		not specified	Uncertain significance (Feb 05, 2024)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

• Function: FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
• Pathway: Neuroactive ligand-receptor interaction - Homo sapiens (human);Signaling by GPCR;Signal Transduction;G alpha (s) signalling events;Amine ligand-binding receptors;Class A/1 (Rhodopsin-like receptors);GPCR ligand binding;GPCR downstream signalling (Consensus)

Mouse Genome Informatics

• Gene name: Taar9

Gene ontology

• Biological process: G protein-coupled receptor signaling pathway
• Cellular component: plasma membrane;integral component of membrane
• Molecular function: trace-amine receptor activity;G protein-coupled receptor activity