Annotate your vcf with ACMG points

You can upload your VCF file here. It will be annotated, and the download will start automatically.


We strongly recommend using our API for variant annotation, either via the raw endpoints (more information available at or by utilizing the Python client ( By employing the API, you can annotate variants in a more controllable manner. Our python client allows you to annotate your vcf from command line. Try also our dockerized client at You will find usage examples at

Please note that we do not support multiallelic sites. Kindly ensure you split them before uploading.

Keep in mind that we have a VCF size limit of 1000 variants.

Kindly be aware that only hg38 is supported.

We do not store your VCF file.