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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-150966805-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=150966805&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 150966805,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_022075.5",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "NM_022075.5",
"protein_id": "NP_071358.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000368954.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_022075.5"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000368954.10",
"protein_id": "ENSP00000357950.5",
"transcript_support_level": 1,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_022075.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368954.10"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.340G>A",
"hgvs_p": "p.Val114Ile",
"transcript": "ENST00000560793.6",
"protein_id": "ENSP00000453297.2",
"transcript_support_level": 1,
"aa_start": 114,
"aa_end": null,
"aa_length": 227,
"cds_start": 340,
"cds_end": null,
"cds_length": 684,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000560793.6"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.838G>A",
"hgvs_p": "p.Val280Ile",
"transcript": "ENST00000955084.1",
"protein_id": "ENSP00000625143.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 393,
"cds_start": 838,
"cds_end": null,
"cds_length": 1182,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955084.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.826G>A",
"hgvs_p": "p.Val276Ile",
"transcript": "ENST00000885841.1",
"protein_id": "ENSP00000555900.1",
"transcript_support_level": null,
"aa_start": 276,
"aa_end": null,
"aa_length": 389,
"cds_start": 826,
"cds_end": null,
"cds_length": 1170,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885841.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "NM_181746.4",
"protein_id": "NP_859530.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_181746.4"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000271688.10",
"protein_id": "ENSP00000271688.6",
"transcript_support_level": 5,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000271688.10"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885835.1",
"protein_id": "ENSP00000555894.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885835.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885836.1",
"protein_id": "ENSP00000555895.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885836.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885837.1",
"protein_id": "ENSP00000555896.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885837.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885848.1",
"protein_id": "ENSP00000555907.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885848.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885849.1",
"protein_id": "ENSP00000555908.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885849.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885850.1",
"protein_id": "ENSP00000555909.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885850.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885851.1",
"protein_id": "ENSP00000555910.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885851.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885852.1",
"protein_id": "ENSP00000555911.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885852.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885853.1",
"protein_id": "ENSP00000555912.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885853.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885854.1",
"protein_id": "ENSP00000555913.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885854.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000885855.1",
"protein_id": "ENSP00000555914.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885855.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000911844.1",
"protein_id": "ENSP00000581903.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000911844.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000911845.1",
"protein_id": "ENSP00000581904.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000911845.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000955081.1",
"protein_id": "ENSP00000625140.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955081.1"
},
{
"aa_ref": "V",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CERS2",
"gene_hgnc_id": 14076,
"hgvs_c": "c.799G>A",
"hgvs_p": "p.Val267Ile",
"transcript": "ENST00000955082.1",
"protein_id": "ENSP00000625141.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 380,
"cds_start": 799,
"cds_end": null,
"cds_length": 1143,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
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}