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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-151406284-T-TG (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=151406284&ref=T&alt=TG&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PVS1",
            "PM2",
            "PP5_Moderate"
          ],
          "effects": [
            "frameshift_variant"
          ],
          "gene_symbol": "POGZ",
          "hgnc_id": 18801,
          "hgvs_c": "c.2771dupC",
          "hgvs_p": "p.Pro925fs",
          "inheritance_mode": "AD",
          "pathogenic_score": 12,
          "score": 12,
          "transcript": "NM_001410860.1",
          "verdict": "Pathogenic"
        }
      ],
      "acmg_classification": "Pathogenic",
      "acmg_criteria": "PVS1,PM2,PP5_Moderate",
      "acmg_score": 12,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "TG",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "1",
      "clinvar_classification": "Pathogenic",
      "clinvar_disease": "not provided",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "P:1",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1410,
          "aa_ref": "P",
          "aa_start": 917,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6655,
          "cdna_start": 3094,
          "cds_end": null,
          "cds_length": 4233,
          "cds_start": 2750,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_015100.4",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2750dupC",
          "hgvs_p": "p.Pro918fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000271715.7",
          "protein_coding": true,
          "protein_id": "NP_055915.2",
          "strand": false,
          "transcript": "NM_015100.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1410,
          "aa_ref": "P",
          "aa_start": 917,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 6655,
          "cdna_start": 3094,
          "cds_end": null,
          "cds_length": 4233,
          "cds_start": 2750,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "ENST00000271715.7",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2750dupC",
          "hgvs_p": "p.Pro918fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_015100.4",
          "protein_coding": true,
          "protein_id": "ENSP00000271715.2",
          "strand": false,
          "transcript": "ENST00000271715.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1357,
          "aa_ref": "P",
          "aa_start": 864,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6181,
          "cdna_start": 2620,
          "cds_end": null,
          "cds_length": 4074,
          "cds_start": 2591,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000392723.6",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2591dupC",
          "hgvs_p": "p.Pro865fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000376484.1",
          "strand": false,
          "transcript": "ENST00000392723.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1315,
          "aa_ref": "P",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6054,
          "cdna_start": 2494,
          "cds_end": null,
          "cds_length": 3948,
          "cds_start": 2465,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 17,
          "exon_rank": 17,
          "exon_rank_end": null,
          "feature": "ENST00000368863.6",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2465dupC",
          "hgvs_p": "p.Pro823fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000357856.2",
          "strand": false,
          "transcript": "ENST00000368863.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1426,
          "aa_ref": "P",
          "aa_start": 933,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6655,
          "cdna_start": 3094,
          "cds_end": null,
          "cds_length": 4281,
          "cds_start": 2798,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "ENST00000710270.1",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2798dupC",
          "hgvs_p": "p.Pro934fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000518163.1",
          "strand": false,
          "transcript": "ENST00000710270.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1417,
          "aa_ref": "P",
          "aa_start": 924,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6452,
          "cdna_start": 2891,
          "cds_end": null,
          "cds_length": 4254,
          "cds_start": 2771,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_001410860.1",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2771dupC",
          "hgvs_p": "p.Pro925fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001397789.1",
          "strand": false,
          "transcript": "NM_001410860.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1417,
          "aa_ref": "P",
          "aa_start": 924,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4350,
          "cdna_start": 2867,
          "cds_end": null,
          "cds_length": 4254,
          "cds_start": 2771,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "ENST00000703168.1",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2771dupC",
          "hgvs_p": "p.Pro925fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000515214.1",
          "strand": false,
          "transcript": "ENST00000703168.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1410,
          "aa_ref": "P",
          "aa_start": 917,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5812,
          "cdna_start": 4329,
          "cds_end": null,
          "cds_length": 4233,
          "cds_start": 2750,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 21,
          "exon_rank": 21,
          "exon_rank_end": null,
          "feature": "ENST00000439756.2",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2750dupC",
          "hgvs_p": "p.Pro918fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000390156.2",
          "strand": false,
          "transcript": "ENST00000439756.2",
          "transcript_support_level": 3
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1401,
          "aa_ref": "P",
          "aa_start": 908,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6628,
          "cdna_start": 3067,
          "cds_end": null,
          "cds_length": 4206,
          "cds_start": 2723,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_001194937.2",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2723dupC",
          "hgvs_p": "p.Pro909fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001181866.1",
          "strand": false,
          "transcript": "NM_001194937.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1401,
          "aa_ref": "P",
          "aa_start": 908,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4813,
          "cdna_start": 2752,
          "cds_end": null,
          "cds_length": 4206,
          "cds_start": 2723,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "ENST00000409503.5",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2723dupC",
          "hgvs_p": "p.Pro909fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000386836.1",
          "strand": false,
          "transcript": "ENST00000409503.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1366,
          "aa_ref": "P",
          "aa_start": 873,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4130,
          "cdna_start": 2647,
          "cds_end": null,
          "cds_length": 4101,
          "cds_start": 2618,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000491586.5",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2618dupC",
          "hgvs_p": "p.Pro874fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000418408.1",
          "strand": false,
          "transcript": "ENST00000491586.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1357,
          "aa_ref": "P",
          "aa_start": 864,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6153,
          "cdna_start": 2592,
          "cds_end": null,
          "cds_length": 4074,
          "cds_start": 2591,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 17,
          "exon_rank": 17,
          "exon_rank_end": null,
          "feature": "NM_207171.2",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2591dupC",
          "hgvs_p": "p.Pro865fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_997054.1",
          "strand": false,
          "transcript": "NM_207171.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1348,
          "aa_ref": "P",
          "aa_start": 855,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6469,
          "cdna_start": 2908,
          "cds_end": null,
          "cds_length": 4047,
          "cds_start": 2564,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "NM_001194938.2",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2564dupC",
          "hgvs_p": "p.Pro856fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001181867.1",
          "strand": false,
          "transcript": "NM_001194938.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1348,
          "aa_ref": "P",
          "aa_start": 855,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4415,
          "cdna_start": 2629,
          "cds_end": null,
          "cds_length": 4047,
          "cds_start": 2564,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000531094.5",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2564dupC",
          "hgvs_p": "p.Pro856fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000431259.1",
          "strand": false,
          "transcript": "ENST00000531094.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1315,
          "aa_ref": "P",
          "aa_start": 822,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6370,
          "cdna_start": 2809,
          "cds_end": null,
          "cds_length": 3948,
          "cds_start": 2465,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 17,
          "exon_rank": 17,
          "exon_rank_end": null,
          "feature": "NM_145796.4",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2465dupC",
          "hgvs_p": "p.Pro823fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_665739.3",
          "strand": false,
          "transcript": "NM_145796.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1410,
          "aa_ref": "P",
          "aa_start": 917,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7188,
          "cdna_start": 3627,
          "cds_end": null,
          "cds_length": 4233,
          "cds_start": 2750,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "XM_005245000.5",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2750dupC",
          "hgvs_p": "p.Pro918fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_005245057.1",
          "strand": false,
          "transcript": "XM_005245000.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1410,
          "aa_ref": "P",
          "aa_start": 917,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6351,
          "cdna_start": 2790,
          "cds_end": null,
          "cds_length": 4233,
          "cds_start": 2750,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "XM_047450064.1",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2750dupC",
          "hgvs_p": "p.Pro918fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047306020.1",
          "strand": false,
          "transcript": "XM_047450064.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1408,
          "aa_ref": "P",
          "aa_start": 915,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6425,
          "cdna_start": 2864,
          "cds_end": null,
          "cds_length": 4227,
          "cds_start": 2744,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "XM_047450065.1",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2744dupC",
          "hgvs_p": "p.Pro916fs",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047306021.1",
          "strand": false,
          "transcript": "XM_047450065.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P?",
          "aa_end": null,
          "aa_length": 1401,
          "aa_ref": "P",
          "aa_start": 908,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7161,
          "cdna_start": 3600,
          "cds_end": null,
          "cds_length": 4206,
          "cds_start": 2723,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "XM_017000746.2",
          "gene_hgnc_id": 18801,
          "gene_symbol": "POGZ",
          "hgvs_c": "c.2723dupC",
          "hgvs_p": "p.Pro909fs",
          "intron_rank": null,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.