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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-155195870-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=155195870&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 155195870,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_001407490.1",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2842C>T",
          "hgvs_p": "p.Arg948Trp",
          "transcript": "NM_007112.5",
          "protein_id": "NP_009043.1",
          "transcript_support_level": null,
          "aa_start": 948,
          "aa_end": null,
          "aa_length": 956,
          "cds_start": 2842,
          "cds_end": null,
          "cds_length": 2871,
          "cdna_start": 2863,
          "cdna_end": null,
          "cdna_length": 3145,
          "mane_select": "ENST00000368378.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_007112.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2842C>T",
          "hgvs_p": "p.Arg948Trp",
          "transcript": "ENST00000368378.7",
          "protein_id": "ENSP00000357362.3",
          "transcript_support_level": 1,
          "aa_start": 948,
          "aa_end": null,
          "aa_length": 956,
          "cds_start": 2842,
          "cds_end": null,
          "cds_length": 2871,
          "cdna_start": 2863,
          "cdna_end": null,
          "cdna_length": 3145,
          "mane_select": "NM_007112.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000368378.7"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2815C>T",
          "hgvs_p": "p.Arg939Trp",
          "transcript": "ENST00000541576.5",
          "protein_id": "ENSP00000444792.2",
          "transcript_support_level": 1,
          "aa_start": 939,
          "aa_end": null,
          "aa_length": 947,
          "cds_start": 2815,
          "cds_end": null,
          "cds_length": 2844,
          "cdna_start": 2920,
          "cdna_end": null,
          "cdna_length": 3200,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000541576.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.1429C>T",
          "hgvs_p": "p.Arg477Trp",
          "transcript": "ENST00000541990.5",
          "protein_id": "ENSP00000437353.1",
          "transcript_support_level": 1,
          "aa_start": 477,
          "aa_end": null,
          "aa_length": 485,
          "cds_start": 1429,
          "cds_end": null,
          "cds_length": 1458,
          "cdna_start": 2849,
          "cdna_end": null,
          "cdna_length": 2928,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000541990.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.3013C>T",
          "hgvs_p": "p.Arg1005Trp",
          "transcript": "NM_001407490.1",
          "protein_id": "NP_001394419.1",
          "transcript_support_level": null,
          "aa_start": 1005,
          "aa_end": null,
          "aa_length": 1013,
          "cds_start": 3013,
          "cds_end": null,
          "cds_length": 3042,
          "cdna_start": 3690,
          "cdna_end": null,
          "cdna_length": 3972,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001407490.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2851C>T",
          "hgvs_p": "p.Arg951Trp",
          "transcript": "NM_001407487.1",
          "protein_id": "NP_001394416.1",
          "transcript_support_level": null,
          "aa_start": 951,
          "aa_end": null,
          "aa_length": 959,
          "cds_start": 2851,
          "cds_end": null,
          "cds_length": 2880,
          "cdna_start": 2872,
          "cdna_end": null,
          "cdna_length": 3154,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001407487.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2851C>T",
          "hgvs_p": "p.Arg951Trp",
          "transcript": "ENST00000902275.1",
          "protein_id": "ENSP00000572334.1",
          "transcript_support_level": null,
          "aa_start": 951,
          "aa_end": null,
          "aa_length": 959,
          "cds_start": 2851,
          "cds_end": null,
          "cds_length": 2880,
          "cdna_start": 2872,
          "cdna_end": null,
          "cdna_length": 3154,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000902275.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2836C>T",
          "hgvs_p": "p.Arg946Trp",
          "transcript": "ENST00000902272.1",
          "protein_id": "ENSP00000572331.1",
          "transcript_support_level": null,
          "aa_start": 946,
          "aa_end": null,
          "aa_length": 954,
          "cds_start": 2836,
          "cds_end": null,
          "cds_length": 2865,
          "cdna_start": 2903,
          "cdna_end": null,
          "cdna_length": 3185,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000902272.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2815C>T",
          "hgvs_p": "p.Arg939Trp",
          "transcript": "NM_001252607.2",
          "protein_id": "NP_001239536.1",
          "transcript_support_level": null,
          "aa_start": 939,
          "aa_end": null,
          "aa_length": 947,
          "cds_start": 2815,
          "cds_end": null,
          "cds_length": 2844,
          "cdna_start": 2836,
          "cdna_end": null,
          "cdna_length": 3118,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001252607.2"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2752C>T",
          "hgvs_p": "p.Arg918Trp",
          "transcript": "NM_001407554.1",
          "protein_id": "NP_001394483.1",
          "transcript_support_level": null,
          "aa_start": 918,
          "aa_end": null,
          "aa_length": 926,
          "cds_start": 2752,
          "cds_end": null,
          "cds_length": 2781,
          "cdna_start": 2773,
          "cdna_end": null,
          "cdna_length": 3055,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001407554.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2749C>T",
          "hgvs_p": "p.Arg917Trp",
          "transcript": "ENST00000960680.1",
          "protein_id": "ENSP00000630739.1",
          "transcript_support_level": null,
          "aa_start": 917,
          "aa_end": null,
          "aa_length": 925,
          "cds_start": 2749,
          "cds_end": null,
          "cds_length": 2778,
          "cdna_start": 2773,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000960680.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2731C>T",
          "hgvs_p": "p.Arg911Trp",
          "transcript": "NM_001407555.1",
          "protein_id": "NP_001394484.1",
          "transcript_support_level": null,
          "aa_start": 911,
          "aa_end": null,
          "aa_length": 919,
          "cds_start": 2731,
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          "cds_length": 2760,
          "cdna_start": 2752,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001407555.1"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
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          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2731C>T",
          "hgvs_p": "p.Arg911Trp",
          "transcript": "ENST00000902273.1",
          "protein_id": "ENSP00000572332.1",
          "transcript_support_level": null,
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          "cds_start": 2731,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000902273.1"
        },
        {
          "aa_ref": "R",
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          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 23,
          "exon_rank_end": null,
          "exon_count": 23,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2728C>T",
          "hgvs_p": "p.Arg910Trp",
          "transcript": "NM_001407556.1",
          "protein_id": "NP_001394485.1",
          "transcript_support_level": null,
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        {
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          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2728C>T",
          "hgvs_p": "p.Arg910Trp",
          "transcript": "NM_001407557.1",
          "protein_id": "NP_001394486.1",
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          "cdna_start": 3134,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001407557.1"
        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
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          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2623C>T",
          "hgvs_p": "p.Arg875Trp",
          "transcript": "ENST00000960681.1",
          "protein_id": "ENSP00000630740.1",
          "transcript_support_level": null,
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        },
        {
          "aa_ref": "R",
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          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 22,
          "exon_rank_end": null,
          "exon_count": 22,
          "intron_rank": null,
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          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2617C>T",
          "hgvs_p": "p.Arg873Trp",
          "transcript": "NM_001407558.1",
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        {
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          "intron_rank": null,
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          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2524C>T",
          "hgvs_p": "p.Arg842Trp",
          "transcript": "ENST00000960679.1",
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        {
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          "intron_rank": null,
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          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2503C>T",
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          "transcript": "ENST00000902274.1",
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          "cds_start": 2503,
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          "cdna_length": 2811,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000902274.1"
        },
        {
          "aa_ref": "R",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "THBS3",
          "gene_hgnc_id": 11787,
          "hgvs_c": "c.2482C>T",
          "hgvs_p": "p.Arg828Trp",
          "transcript": "NM_001252608.2",
          "protein_id": "NP_001239537.1",
          "transcript_support_level": null,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.