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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-155310175-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=155310175&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 155310175,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_002004.4",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "NM_002004.4",
"protein_id": "NP_001995.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 419,
"cds_start": 309,
"cds_end": null,
"cds_length": 1260,
"cdna_start": 410,
"cdna_end": null,
"cdna_length": 1417,
"mane_select": "ENST00000368356.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_002004.4"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000368356.9",
"protein_id": "ENSP00000357340.4",
"transcript_support_level": 2,
"aa_start": 103,
"aa_end": null,
"aa_length": 419,
"cds_start": 309,
"cds_end": null,
"cds_length": 1260,
"cdna_start": 410,
"cdna_end": null,
"cdna_length": 1417,
"mane_select": "NM_002004.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368356.9"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000356657.10",
"protein_id": "ENSP00000349078.6",
"transcript_support_level": 1,
"aa_start": 103,
"aa_end": null,
"aa_length": 419,
"cds_start": 309,
"cds_end": null,
"cds_length": 1260,
"cdna_start": 471,
"cdna_end": null,
"cdna_length": 1478,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000356657.10"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "NM_001135821.2",
"protein_id": "NP_001129293.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 419,
"cds_start": 309,
"cds_end": null,
"cds_length": 1260,
"cdna_start": 521,
"cdna_end": null,
"cdna_length": 1528,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001135821.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000851541.1",
"protein_id": "ENSP00000521600.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 419,
"cds_start": 309,
"cds_end": null,
"cds_length": 1260,
"cdna_start": 4002,
"cdna_end": null,
"cdna_length": 5010,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851541.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000851544.1",
"protein_id": "ENSP00000521603.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 419,
"cds_start": 309,
"cds_end": null,
"cds_length": 1260,
"cdna_start": 386,
"cdna_end": null,
"cdna_length": 1392,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851544.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000851549.1",
"protein_id": "ENSP00000521608.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 415,
"cds_start": 309,
"cds_end": null,
"cds_length": 1248,
"cdna_start": 328,
"cdna_end": null,
"cdna_length": 1323,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851549.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000851548.1",
"protein_id": "ENSP00000521607.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 407,
"cds_start": 309,
"cds_end": null,
"cds_length": 1224,
"cdna_start": 442,
"cdna_end": null,
"cdna_length": 1413,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851548.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000851547.1",
"protein_id": "ENSP00000521606.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 403,
"cds_start": 309,
"cds_end": null,
"cds_length": 1212,
"cdna_start": 337,
"cdna_end": null,
"cdna_length": 1295,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851547.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000851551.1",
"protein_id": "ENSP00000521610.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 403,
"cds_start": 309,
"cds_end": null,
"cds_length": 1212,
"cdna_start": 427,
"cdna_end": null,
"cdna_length": 1386,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851551.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000930253.1",
"protein_id": "ENSP00000600312.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 403,
"cds_start": 309,
"cds_end": null,
"cds_length": 1212,
"cdna_start": 447,
"cdna_end": null,
"cdna_length": 1406,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930253.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000930254.1",
"protein_id": "ENSP00000600313.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 388,
"cds_start": 309,
"cds_end": null,
"cds_length": 1167,
"cdna_start": 334,
"cdna_end": null,
"cdna_length": 1246,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930254.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000930255.1",
"protein_id": "ENSP00000600314.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 388,
"cds_start": 309,
"cds_end": null,
"cds_length": 1167,
"cdna_start": 439,
"cdna_end": null,
"cdna_length": 1353,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930255.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000851540.1",
"protein_id": "ENSP00000521599.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 374,
"cds_start": 309,
"cds_end": null,
"cds_length": 1125,
"cdna_start": 526,
"cdna_end": null,
"cdna_length": 1399,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851540.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000851545.1",
"protein_id": "ENSP00000521604.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 374,
"cds_start": 309,
"cds_end": null,
"cds_length": 1125,
"cdna_start": 447,
"cdna_end": null,
"cdna_length": 1319,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851545.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000851554.1",
"protein_id": "ENSP00000521612.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 374,
"cds_start": 309,
"cds_end": null,
"cds_length": 1125,
"cdna_start": 392,
"cdna_end": null,
"cdna_length": 1264,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851554.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.309G>T",
"hgvs_p": "p.Glu103Asp",
"transcript": "ENST00000930252.1",
"protein_id": "ENSP00000600311.1",
"transcript_support_level": null,
"aa_start": 103,
"aa_end": null,
"aa_length": 374,
"cds_start": 309,
"cds_end": null,
"cds_length": 1125,
"cdna_start": 435,
"cdna_end": null,
"cdna_length": 1308,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000930252.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.288G>T",
"hgvs_p": "p.Glu96Asp",
"transcript": "ENST00000851542.1",
"protein_id": "ENSP00000521601.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 367,
"cds_start": 288,
"cds_end": null,
"cds_length": 1104,
"cdna_start": 1278,
"cdna_end": null,
"cdna_length": 2150,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851542.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.288G>T",
"hgvs_p": "p.Glu96Asp",
"transcript": "ENST00000851546.1",
"protein_id": "ENSP00000521605.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 367,
"cds_start": 288,
"cds_end": null,
"cds_length": 1104,
"cdna_start": 315,
"cdna_end": null,
"cdna_length": 1187,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000851546.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.288G>T",
"hgvs_p": "p.Glu96Asp",
"transcript": "ENST00000947439.1",
"protein_id": "ENSP00000617498.1",
"transcript_support_level": null,
"aa_start": 96,
"aa_end": null,
"aa_length": 367,
"cds_start": 288,
"cds_end": null,
"cds_length": 1104,
"cdna_start": 451,
"cdna_end": null,
"cdna_length": 1323,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947439.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.111G>T",
"hgvs_p": "p.Glu37Asp",
"transcript": "NM_001135822.2",
"protein_id": "NP_001129294.1",
"transcript_support_level": null,
"aa_start": 37,
"aa_end": null,
"aa_length": 353,
"cds_start": 111,
"cds_end": null,
"cds_length": 1062,
"cdna_start": 212,
"cdna_end": null,
"cdna_length": 1219,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001135822.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FDPS",
"gene_hgnc_id": 3631,
"hgvs_c": "c.111G>T",
"hgvs_p": "p.Glu37Asp",
"transcript": "NM_001242824.2",
"protein_id": "NP_001229753.1",
"transcript_support_level": null,
"aa_start": 37,
"aa_end": null,
"aa_length": 353,
"cds_start": 111,
"cds_end": null,
"cds_length": 1062,
"cdna_start": 233,
"cdna_end": null,
"cdna_length": 1240,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001242824.2"
},
{
"aa_ref": "E",
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}
],
"message": null
}