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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-156311005-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=156311005&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 156311005,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_005998.5",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1346G>T",
"hgvs_p": "p.Arg449Leu",
"transcript": "NM_005998.5",
"protein_id": "NP_005989.3",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 545,
"cds_start": 1346,
"cds_end": null,
"cds_length": 1638,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000295688.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005998.5"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1346G>T",
"hgvs_p": "p.Arg449Leu",
"transcript": "ENST00000295688.8",
"protein_id": "ENSP00000295688.3",
"transcript_support_level": 1,
"aa_start": 449,
"aa_end": null,
"aa_length": 545,
"cds_start": 1346,
"cds_end": null,
"cds_length": 1638,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005998.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000295688.8"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1367G>T",
"hgvs_p": "p.Arg456Leu",
"transcript": "ENST00000954294.1",
"protein_id": "ENSP00000624353.1",
"transcript_support_level": null,
"aa_start": 456,
"aa_end": null,
"aa_length": 552,
"cds_start": 1367,
"cds_end": null,
"cds_length": 1659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954294.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1361G>T",
"hgvs_p": "p.Arg454Leu",
"transcript": "ENST00000898516.1",
"protein_id": "ENSP00000568575.1",
"transcript_support_level": null,
"aa_start": 454,
"aa_end": null,
"aa_length": 550,
"cds_start": 1361,
"cds_end": null,
"cds_length": 1653,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898516.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1346G>T",
"hgvs_p": "p.Arg449Leu",
"transcript": "ENST00000940011.1",
"protein_id": "ENSP00000610070.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 545,
"cds_start": 1346,
"cds_end": null,
"cds_length": 1638,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940011.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1343G>T",
"hgvs_p": "p.Arg448Leu",
"transcript": "ENST00000940013.1",
"protein_id": "ENSP00000610072.1",
"transcript_support_level": null,
"aa_start": 448,
"aa_end": null,
"aa_length": 544,
"cds_start": 1343,
"cds_end": null,
"cds_length": 1635,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940013.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1346G>T",
"hgvs_p": "p.Arg449Leu",
"transcript": "ENST00000954292.1",
"protein_id": "ENSP00000624351.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 543,
"cds_start": 1346,
"cds_end": null,
"cds_length": 1632,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954292.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1334G>T",
"hgvs_p": "p.Arg445Leu",
"transcript": "ENST00000940017.1",
"protein_id": "ENSP00000610076.1",
"transcript_support_level": null,
"aa_start": 445,
"aa_end": null,
"aa_length": 541,
"cds_start": 1334,
"cds_end": null,
"cds_length": 1626,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940017.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1325G>T",
"hgvs_p": "p.Arg442Leu",
"transcript": "ENST00000940012.1",
"protein_id": "ENSP00000610071.1",
"transcript_support_level": null,
"aa_start": 442,
"aa_end": null,
"aa_length": 538,
"cds_start": 1325,
"cds_end": null,
"cds_length": 1617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940012.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1295G>T",
"hgvs_p": "p.Arg432Leu",
"transcript": "ENST00000954295.1",
"protein_id": "ENSP00000624354.1",
"transcript_support_level": null,
"aa_start": 432,
"aa_end": null,
"aa_length": 528,
"cds_start": 1295,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954295.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1283G>T",
"hgvs_p": "p.Arg428Leu",
"transcript": "ENST00000940020.1",
"protein_id": "ENSP00000610079.1",
"transcript_support_level": null,
"aa_start": 428,
"aa_end": null,
"aa_length": 524,
"cds_start": 1283,
"cds_end": null,
"cds_length": 1575,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940020.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1280G>T",
"hgvs_p": "p.Arg427Leu",
"transcript": "ENST00000940022.1",
"protein_id": "ENSP00000610081.1",
"transcript_support_level": null,
"aa_start": 427,
"aa_end": null,
"aa_length": 523,
"cds_start": 1280,
"cds_end": null,
"cds_length": 1572,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940022.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1232G>T",
"hgvs_p": "p.Arg411Leu",
"transcript": "NM_001008800.3",
"protein_id": "NP_001008800.1",
"transcript_support_level": null,
"aa_start": 411,
"aa_end": null,
"aa_length": 507,
"cds_start": 1232,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001008800.3"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1232G>T",
"hgvs_p": "p.Arg411Leu",
"transcript": "ENST00000368259.6",
"protein_id": "ENSP00000357242.2",
"transcript_support_level": 2,
"aa_start": 411,
"aa_end": null,
"aa_length": 507,
"cds_start": 1232,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368259.6"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1229G>T",
"hgvs_p": "p.Arg410Leu",
"transcript": "ENST00000954293.1",
"protein_id": "ENSP00000624352.1",
"transcript_support_level": null,
"aa_start": 410,
"aa_end": null,
"aa_length": 506,
"cds_start": 1229,
"cds_end": null,
"cds_length": 1521,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000954293.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1346G>T",
"hgvs_p": "p.Arg449Leu",
"transcript": "ENST00000940018.1",
"protein_id": "ENSP00000610077.1",
"transcript_support_level": null,
"aa_start": 449,
"aa_end": null,
"aa_length": 501,
"cds_start": 1346,
"cds_end": null,
"cds_length": 1506,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940018.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1211G>T",
"hgvs_p": "p.Arg404Leu",
"transcript": "ENST00000472765.6",
"protein_id": "ENSP00000431543.1",
"transcript_support_level": 2,
"aa_start": 404,
"aa_end": null,
"aa_length": 500,
"cds_start": 1211,
"cds_end": null,
"cds_length": 1503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000472765.6"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1196G>T",
"hgvs_p": "p.Arg399Leu",
"transcript": "ENST00000940016.1",
"protein_id": "ENSP00000610075.1",
"transcript_support_level": null,
"aa_start": 399,
"aa_end": null,
"aa_length": 495,
"cds_start": 1196,
"cds_end": null,
"cds_length": 1488,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940016.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.1073G>T",
"hgvs_p": "p.Arg358Leu",
"transcript": "ENST00000940021.1",
"protein_id": "ENSP00000610080.1",
"transcript_support_level": null,
"aa_start": 358,
"aa_end": null,
"aa_length": 454,
"cds_start": 1073,
"cds_end": null,
"cds_length": 1365,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940021.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.977G>T",
"hgvs_p": "p.Arg326Leu",
"transcript": "ENST00000940015.1",
"protein_id": "ENSP00000610074.1",
"transcript_support_level": null,
"aa_start": 326,
"aa_end": null,
"aa_length": 422,
"cds_start": 977,
"cds_end": null,
"cds_length": 1269,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940015.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.896G>T",
"hgvs_p": "p.Arg299Leu",
"transcript": "ENST00000898517.1",
"protein_id": "ENSP00000568576.1",
"transcript_support_level": null,
"aa_start": 299,
"aa_end": null,
"aa_length": 395,
"cds_start": 896,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898517.1"
},
{
"aa_ref": "R",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CCT3",
"gene_hgnc_id": 1616,
"hgvs_c": "c.830G>T",
"hgvs_p": "p.Arg277Leu",
"transcript": "ENST00000940019.1",
"protein_id": "ENSP00000610078.1",
"transcript_support_level": null,
"aa_start": 277,
"aa_end": null,
"aa_length": 373,
"cds_start": 830,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940019.1"
},
{
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}
],
"message": null
}