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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-156937289-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=156937289&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 156937289,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_198236.3",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4400A>G",
"hgvs_p": "p.His1467Arg",
"transcript": "NM_198236.3",
"protein_id": "NP_937879.1",
"transcript_support_level": null,
"aa_start": 1467,
"aa_end": null,
"aa_length": 1562,
"cds_start": 4400,
"cds_end": null,
"cds_length": 4689,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000368194.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_198236.3"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4400A>G",
"hgvs_p": "p.His1467Arg",
"transcript": "ENST00000368194.8",
"protein_id": "ENSP00000357177.3",
"transcript_support_level": 1,
"aa_start": 1467,
"aa_end": null,
"aa_length": 1562,
"cds_start": 4400,
"cds_end": null,
"cds_length": 4689,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_198236.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000368194.8"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 38,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4280A>G",
"hgvs_p": "p.His1427Arg",
"transcript": "ENST00000361409.2",
"protein_id": "ENSP00000354644.2",
"transcript_support_level": 1,
"aa_start": 1427,
"aa_end": null,
"aa_length": 1522,
"cds_start": 4280,
"cds_end": null,
"cds_length": 4569,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361409.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 43,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4448A>G",
"hgvs_p": "p.His1483Arg",
"transcript": "ENST00000715594.1",
"protein_id": "ENSP00000520488.1",
"transcript_support_level": null,
"aa_start": 1483,
"aa_end": null,
"aa_length": 1578,
"cds_start": 4448,
"cds_end": null,
"cds_length": 4737,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000715594.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4403A>G",
"hgvs_p": "p.His1468Arg",
"transcript": "ENST00000956715.1",
"protein_id": "ENSP00000626774.1",
"transcript_support_level": null,
"aa_start": 1468,
"aa_end": null,
"aa_length": 1563,
"cds_start": 4403,
"cds_end": null,
"cds_length": 4692,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956715.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4391A>G",
"hgvs_p": "p.His1464Arg",
"transcript": "NM_001377418.1",
"protein_id": "NP_001364347.1",
"transcript_support_level": null,
"aa_start": 1464,
"aa_end": null,
"aa_length": 1559,
"cds_start": 4391,
"cds_end": null,
"cds_length": 4680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377418.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 39,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4388A>G",
"hgvs_p": "p.His1463Arg",
"transcript": "ENST00000715595.1",
"protein_id": "ENSP00000520489.1",
"transcript_support_level": null,
"aa_start": 1463,
"aa_end": null,
"aa_length": 1558,
"cds_start": 4388,
"cds_end": null,
"cds_length": 4677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000715595.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 38,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4370A>G",
"hgvs_p": "p.His1457Arg",
"transcript": "NM_001377419.1",
"protein_id": "NP_001364348.1",
"transcript_support_level": null,
"aa_start": 1457,
"aa_end": null,
"aa_length": 1552,
"cds_start": 4370,
"cds_end": null,
"cds_length": 4659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377419.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 38,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4370A>G",
"hgvs_p": "p.His1457Arg",
"transcript": "ENST00000956713.1",
"protein_id": "ENSP00000626772.1",
"transcript_support_level": null,
"aa_start": 1457,
"aa_end": null,
"aa_length": 1552,
"cds_start": 4370,
"cds_end": null,
"cds_length": 4659,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956713.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 40,
"exon_rank_end": null,
"exon_count": 42,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4328A>G",
"hgvs_p": "p.His1443Arg",
"transcript": "ENST00000956714.1",
"protein_id": "ENSP00000626773.1",
"transcript_support_level": null,
"aa_start": 1443,
"aa_end": null,
"aa_length": 1538,
"cds_start": 4328,
"cds_end": null,
"cds_length": 4617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956714.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 38,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4307A>G",
"hgvs_p": "p.His1436Arg",
"transcript": "ENST00000935553.1",
"protein_id": "ENSP00000605612.1",
"transcript_support_level": null,
"aa_start": 1436,
"aa_end": null,
"aa_length": 1531,
"cds_start": 4307,
"cds_end": null,
"cds_length": 4596,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935553.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 38,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4304A>G",
"hgvs_p": "p.His1435Arg",
"transcript": "ENST00000935551.1",
"protein_id": "ENSP00000605610.1",
"transcript_support_level": null,
"aa_start": 1435,
"aa_end": null,
"aa_length": 1530,
"cds_start": 4304,
"cds_end": null,
"cds_length": 4593,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935551.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 38,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4283A>G",
"hgvs_p": "p.His1428Arg",
"transcript": "ENST00000956711.1",
"protein_id": "ENSP00000626770.1",
"transcript_support_level": null,
"aa_start": 1428,
"aa_end": null,
"aa_length": 1523,
"cds_start": 4283,
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"cds_length": 4572,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956711.1"
},
{
"aa_ref": "H",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 38,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
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"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4280A>G",
"hgvs_p": "p.His1427Arg",
"transcript": "NM_014784.4",
"protein_id": "NP_055599.1",
"transcript_support_level": null,
"aa_start": 1427,
"aa_end": null,
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"cds_start": 4280,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014784.4"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 37,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4277A>G",
"hgvs_p": "p.His1426Arg",
"transcript": "ENST00000935554.1",
"protein_id": "ENSP00000605613.1",
"transcript_support_level": null,
"aa_start": 1426,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000935554.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 37,
"exon_rank_end": null,
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"intron_rank": null,
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"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4274A>G",
"hgvs_p": "p.His1425Arg",
"transcript": "ENST00000935557.1",
"protein_id": "ENSP00000605616.1",
"transcript_support_level": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935557.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 37,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4256A>G",
"hgvs_p": "p.His1419Arg",
"transcript": "ENST00000956712.1",
"protein_id": "ENSP00000626771.1",
"transcript_support_level": null,
"aa_start": 1419,
"aa_end": null,
"aa_length": 1514,
"cds_start": 4256,
"cds_end": null,
"cds_length": 4545,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956712.1"
},
{
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"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 37,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4187A>G",
"hgvs_p": "p.His1396Arg",
"transcript": "ENST00000935556.1",
"protein_id": "ENSP00000605615.1",
"transcript_support_level": null,
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"feature": "ENST00000935556.1"
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 37,
"exon_rank_end": null,
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"intron_rank": null,
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"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4184A>G",
"hgvs_p": "p.His1395Arg",
"transcript": "ENST00000935552.1",
"protein_id": "ENSP00000605611.1",
"transcript_support_level": null,
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"aa_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935552.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 36,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4154A>G",
"hgvs_p": "p.His1385Arg",
"transcript": "ENST00000935555.1",
"protein_id": "ENSP00000605614.1",
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935555.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 36,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4112A>G",
"hgvs_p": "p.His1371Arg",
"transcript": "ENST00000935558.1",
"protein_id": "ENSP00000605617.1",
"transcript_support_level": null,
"aa_start": 1371,
"aa_end": null,
"aa_length": 1466,
"cds_start": 4112,
"cds_end": null,
"cds_length": 4401,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935558.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 41,
"exon_rank_end": null,
"exon_count": 43,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGEF11",
"gene_hgnc_id": 14580,
"hgvs_c": "c.4451A>G",
"hgvs_p": "p.His1484Arg",
"transcript": "XM_006711659.4",
"protein_id": "XP_006711722.1",
"transcript_support_level": null,
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{
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],
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"computational_prediction_selected": "Benign",
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"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
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"bayesdelnoaf_score": -0.68,
"bayesdelnoaf_prediction": "Benign",
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"phylop100way_prediction": "Benign",
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"spliceai_max_prediction": "Benign",
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"acmg_classification": "Benign",
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"acmg_by_gene": [
{
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"criteria": [
"BP4_Strong",
"BA1"
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"verdict": "Benign",
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"effects": [
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{
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"BA1"
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"verdict": "Benign",
"transcript": "XM_017000459.3",
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}
],
"clinvar_disease": "",
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"clinvar_review_status": "",
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"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}