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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-16055706-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=16055706&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 16055706,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_000085.5",
"consequences": [
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1877G>T",
"hgvs_p": "p.Cys626Phe",
"transcript": "NM_000085.5",
"protein_id": "NP_000076.2",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 687,
"cds_start": 1877,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000375679.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000085.5"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1877G>T",
"hgvs_p": "p.Cys626Phe",
"transcript": "ENST00000375679.9",
"protein_id": "ENSP00000364831.5",
"transcript_support_level": 1,
"aa_start": 626,
"aa_end": null,
"aa_length": 687,
"cds_start": 1877,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000085.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000375679.9"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1931G>T",
"hgvs_p": "p.Cys644Phe",
"transcript": "ENST00000906263.1",
"protein_id": "ENSP00000576322.1",
"transcript_support_level": null,
"aa_start": 644,
"aa_end": null,
"aa_length": 705,
"cds_start": 1931,
"cds_end": null,
"cds_length": 2118,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906263.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1928G>T",
"hgvs_p": "p.Cys643Phe",
"transcript": "ENST00000906270.1",
"protein_id": "ENSP00000576329.1",
"transcript_support_level": null,
"aa_start": 643,
"aa_end": null,
"aa_length": 704,
"cds_start": 1928,
"cds_end": null,
"cds_length": 2115,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906270.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1874G>T",
"hgvs_p": "p.Cys625Phe",
"transcript": "ENST00000906271.1",
"protein_id": "ENSP00000576330.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 694,
"cds_start": 1874,
"cds_end": null,
"cds_length": 2085,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906271.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1895G>T",
"hgvs_p": "p.Cys632Phe",
"transcript": "ENST00000906265.1",
"protein_id": "ENSP00000576324.1",
"transcript_support_level": null,
"aa_start": 632,
"aa_end": null,
"aa_length": 693,
"cds_start": 1895,
"cds_end": null,
"cds_length": 2082,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906265.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1892G>T",
"hgvs_p": "p.Cys631Phe",
"transcript": "ENST00000906262.1",
"protein_id": "ENSP00000576321.1",
"transcript_support_level": null,
"aa_start": 631,
"aa_end": null,
"aa_length": 692,
"cds_start": 1892,
"cds_end": null,
"cds_length": 2079,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906262.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1889G>T",
"hgvs_p": "p.Cys630Phe",
"transcript": "ENST00000906261.1",
"protein_id": "ENSP00000576320.1",
"transcript_support_level": null,
"aa_start": 630,
"aa_end": null,
"aa_length": 691,
"cds_start": 1889,
"cds_end": null,
"cds_length": 2076,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906261.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1886G>T",
"hgvs_p": "p.Cys629Phe",
"transcript": "ENST00000906268.1",
"protein_id": "ENSP00000576327.1",
"transcript_support_level": null,
"aa_start": 629,
"aa_end": null,
"aa_length": 690,
"cds_start": 1886,
"cds_end": null,
"cds_length": 2073,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906268.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1877G>T",
"hgvs_p": "p.Cys626Phe",
"transcript": "ENST00000682338.1",
"protein_id": "ENSP00000507062.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 687,
"cds_start": 1877,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000682338.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1877G>T",
"hgvs_p": "p.Cys626Phe",
"transcript": "ENST00000682793.1",
"protein_id": "ENSP00000506910.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 687,
"cds_start": 1877,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000682793.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1877G>T",
"hgvs_p": "p.Cys626Phe",
"transcript": "ENST00000684324.1",
"protein_id": "ENSP00000507937.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 687,
"cds_start": 1877,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000684324.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1877G>T",
"hgvs_p": "p.Cys626Phe",
"transcript": "ENST00000684545.1",
"protein_id": "ENSP00000506733.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 687,
"cds_start": 1877,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000684545.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1877G>T",
"hgvs_p": "p.Cys626Phe",
"transcript": "ENST00000906275.1",
"protein_id": "ENSP00000576334.1",
"transcript_support_level": null,
"aa_start": 626,
"aa_end": null,
"aa_length": 687,
"cds_start": 1877,
"cds_end": null,
"cds_length": 2064,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906275.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1874G>T",
"hgvs_p": "p.Cys625Phe",
"transcript": "ENST00000683578.1",
"protein_id": "ENSP00000507430.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 686,
"cds_start": 1874,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000683578.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1874G>T",
"hgvs_p": "p.Cys625Phe",
"transcript": "ENST00000906258.1",
"protein_id": "ENSP00000576317.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 686,
"cds_start": 1874,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906258.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1874G>T",
"hgvs_p": "p.Cys625Phe",
"transcript": "ENST00000906259.1",
"protein_id": "ENSP00000576318.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 686,
"cds_start": 1874,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906259.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1874G>T",
"hgvs_p": "p.Cys625Phe",
"transcript": "ENST00000906274.1",
"protein_id": "ENSP00000576333.1",
"transcript_support_level": null,
"aa_start": 625,
"aa_end": null,
"aa_length": 686,
"cds_start": 1874,
"cds_end": null,
"cds_length": 2061,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906274.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1868G>T",
"hgvs_p": "p.Cys623Phe",
"transcript": "ENST00000906272.1",
"protein_id": "ENSP00000576331.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 684,
"cds_start": 1868,
"cds_end": null,
"cds_length": 2055,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906272.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1865G>T",
"hgvs_p": "p.Cys622Phe",
"transcript": "ENST00000906260.1",
"protein_id": "ENSP00000576319.1",
"transcript_support_level": null,
"aa_start": 622,
"aa_end": null,
"aa_length": 683,
"cds_start": 1865,
"cds_end": null,
"cds_length": 2052,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906260.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1817G>T",
"hgvs_p": "p.Cys606Phe",
"transcript": "ENST00000906269.1",
"protein_id": "ENSP00000576328.1",
"transcript_support_level": null,
"aa_start": 606,
"aa_end": null,
"aa_length": 667,
"cds_start": 1817,
"cds_end": null,
"cds_length": 2004,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906269.1"
},
{
"aa_ref": "C",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLCNKB",
"gene_hgnc_id": 2027,
"hgvs_c": "c.1814G>T",
"hgvs_p": "p.Cys605Phe",
"transcript": "ENST00000906266.1",
"protein_id": "ENSP00000576325.1",
"transcript_support_level": null,
"aa_start": 605,
"aa_end": null,
"aa_length": 666,
"cds_start": 1814,
"cds_end": null,
"cds_length": 2001,
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}
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}