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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-161171922-G-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=161171922&ref=G&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 6,
          "criteria": [
            "BP4_Moderate",
            "BS2"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "B4GALT3",
          "hgnc_id": 926,
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -6,
          "transcript": "NM_003779.4",
          "verdict": "Likely_benign"
        },
        {
          "benign_score": 6,
          "criteria": [
            "BP4_Moderate",
            "BS2"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "PPOX",
          "hgnc_id": 9280,
          "hgvs_c": "c.237+1153G>C",
          "hgvs_p": null,
          "inheritance_mode": "AD,SD,AR",
          "pathogenic_score": 0,
          "score": -6,
          "transcript": "ENST00000535223.5",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Moderate,BS2",
      "acmg_score": -6,
      "allele_count_reference_population": 572,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.0612,
      "alt": "C",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.17,
      "chr": "1",
      "clinvar_classification": "Uncertain significance",
      "clinvar_disease": "not specified",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.13707831501960754,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1933,
          "cdna_start": 1321,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "NM_003779.4",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000319769.10",
          "protein_coding": true,
          "protein_id": "NP_003770.1",
          "strand": false,
          "transcript": "NM_003779.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1933,
          "cdna_start": 1321,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000319769.10",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_003779.4",
          "protein_coding": true,
          "protein_id": "ENSP00000320965.5",
          "strand": false,
          "transcript": "ENST00000319769.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1871,
          "cdna_start": 1261,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000367998.5",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000356977.1",
          "strand": false,
          "transcript": "ENST00000367998.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2414,
          "cdna_start": 1803,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000622395.4",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000480428.1",
          "strand": false,
          "transcript": "ENST00000622395.4",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 405,
          "aa_ref": "P",
          "aa_start": 371,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1992,
          "cdna_start": 1380,
          "cds_end": null,
          "cds_length": 1218,
          "cds_start": 1112,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000907555.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1112C>G",
          "hgvs_p": "p.Pro371Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577614.1",
          "strand": false,
          "transcript": "ENST00000907555.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 405,
          "aa_ref": "P",
          "aa_start": 371,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1960,
          "cdna_start": 1348,
          "cds_end": null,
          "cds_length": 1218,
          "cds_start": 1112,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000907560.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1112C>G",
          "hgvs_p": "p.Pro371Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577619.1",
          "strand": false,
          "transcript": "ENST00000907560.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 404,
          "aa_ref": "P",
          "aa_start": 370,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1959,
          "cdna_start": 1350,
          "cds_end": null,
          "cds_length": 1215,
          "cds_start": 1109,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000940286.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1109C>G",
          "hgvs_p": "p.Pro370Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610345.1",
          "strand": false,
          "transcript": "ENST00000940286.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 400,
          "aa_ref": "P",
          "aa_start": 366,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1965,
          "cdna_start": 1353,
          "cds_end": null,
          "cds_length": 1203,
          "cds_start": 1097,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000940283.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1097C>G",
          "hgvs_p": "p.Pro366Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610342.1",
          "strand": false,
          "transcript": "ENST00000940283.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2415,
          "cdna_start": 1803,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "NM_001199873.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001186802.1",
          "strand": false,
          "transcript": "NM_001199873.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2344,
          "cdna_start": 1732,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "NM_001199874.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001186803.1",
          "strand": false,
          "transcript": "NM_001199874.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3921,
          "cdna_start": 3309,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000907550.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577609.1",
          "strand": false,
          "transcript": "ENST00000907550.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2143,
          "cdna_start": 1531,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000907551.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577610.1",
          "strand": false,
          "transcript": "ENST00000907551.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2197,
          "cdna_start": 1587,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000907552.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577611.1",
          "strand": false,
          "transcript": "ENST00000907552.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1874,
          "cdna_start": 1262,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000907553.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577612.1",
          "strand": false,
          "transcript": "ENST00000907553.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2156,
          "cdna_start": 1544,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000907554.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577613.1",
          "strand": false,
          "transcript": "ENST00000907554.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2000,
          "cdna_start": 1388,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000907556.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577615.1",
          "strand": false,
          "transcript": "ENST00000907556.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1964,
          "cdna_start": 1354,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000907557.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577616.1",
          "strand": false,
          "transcript": "ENST00000907557.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1765,
          "cdna_start": 1153,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 1076,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000907559.1",
          "gene_hgnc_id": 926,
          "gene_symbol": "B4GALT3",
          "hgvs_c": "c.1076C>G",
          "hgvs_p": "p.Pro359Arg",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000577618.1",
          "strand": false,
          "transcript": "ENST00000907559.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "R",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "P",
          "aa_start": 359,
          "biotype": "protein_coding",
          "canonical": false,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.