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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-161175220-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=161175220&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 161175220,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_003779.4",
      "consequences": [
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "NM_003779.4",
          "protein_id": "NP_003770.1",
          "transcript_support_level": null,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 393,
          "cds_start": 262,
          "cds_end": null,
          "cds_length": 1182,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000319769.10",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_003779.4"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000319769.10",
          "protein_id": "ENSP00000320965.5",
          "transcript_support_level": 1,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 393,
          "cds_start": 262,
          "cds_end": null,
          "cds_length": 1182,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_003779.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000319769.10"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000367998.5",
          "protein_id": "ENSP00000356977.1",
          "transcript_support_level": 1,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 393,
          "cds_start": 262,
          "cds_end": null,
          "cds_length": 1182,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000367998.5"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000622395.4",
          "protein_id": "ENSP00000480428.1",
          "transcript_support_level": 1,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 393,
          "cds_start": 262,
          "cds_end": null,
          "cds_length": 1182,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000622395.4"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000907555.1",
          "protein_id": "ENSP00000577614.1",
          "transcript_support_level": null,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 405,
          "cds_start": 262,
          "cds_end": null,
          "cds_length": 1218,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000907555.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000907560.1",
          "protein_id": "ENSP00000577619.1",
          "transcript_support_level": null,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 405,
          "cds_start": 262,
          "cds_end": null,
          "cds_length": 1218,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000907560.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000940286.1",
          "protein_id": "ENSP00000610345.1",
          "transcript_support_level": null,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 404,
          "cds_start": 262,
          "cds_end": null,
          "cds_length": 1215,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000940286.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000940283.1",
          "protein_id": "ENSP00000610342.1",
          "transcript_support_level": null,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 400,
          "cds_start": 262,
          "cds_end": null,
          "cds_length": 1203,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000940283.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "NM_001199873.1",
          "protein_id": "NP_001186802.1",
          "transcript_support_level": null,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 393,
          "cds_start": 262,
          "cds_end": null,
          "cds_length": 1182,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001199873.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "NM_001199874.1",
          "protein_id": "NP_001186803.1",
          "transcript_support_level": null,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 393,
          "cds_start": 262,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001199874.1"
        },
        {
          "aa_ref": "V",
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000907550.1",
          "protein_id": "ENSP00000577609.1",
          "transcript_support_level": null,
          "aa_start": 88,
          "aa_end": null,
          "aa_length": 393,
          "cds_start": 262,
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          "cds_length": 1182,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        {
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          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 9,
          "intron_rank": null,
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          "gene_symbol": "B4GALT3",
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          "transcript": "ENST00000907551.1",
          "protein_id": "ENSP00000577610.1",
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          "cds_start": 262,
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        {
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          "strand": false,
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          ],
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          "exon_count": 10,
          "intron_rank": null,
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          "hgvs_c": "c.262G>A",
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        {
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          "canonical": false,
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          "strand": false,
          "consequences": [
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          ],
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          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
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          "gene_symbol": "B4GALT3",
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          "hgvs_c": "c.262G>A",
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          "transcript": "ENST00000907553.1",
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        {
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          "transcript": "ENST00000907554.1",
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          "cds_start": 262,
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        },
        {
          "aa_ref": "V",
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 5,
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          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000907556.1",
          "protein_id": "ENSP00000577615.1",
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        {
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          "exon_rank_end": null,
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          "intron_rank": null,
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          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000907557.1",
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        {
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          "intron_rank": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "V",
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          ],
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          "gene_symbol": "B4GALT3",
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          "transcript": "ENST00000907561.1",
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000907561.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "B4GALT3",
          "gene_hgnc_id": 926,
          "hgvs_c": "c.262G>A",
          "hgvs_p": "p.Val88Met",
          "transcript": "ENST00000907563.1",
          "protein_id": "ENSP00000577622.1",
          "transcript_support_level": null,
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          "cds_start": 262,
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          "cdna_length": null,
          "mane_select": null,
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          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000535223.5",
          "gene_symbol": "PPOX",
          "hgnc_id": 9280,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "AD,AR,SD",
          "hgvs_c": "c.238-1629C>T",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}