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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-161547594-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=161547594&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 161547594,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000443193.6",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.319+827A>C",
"hgvs_p": null,
"transcript": "NM_000569.8",
"protein_id": "NP_000560.7",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 254,
"cds_start": -4,
"cds_end": null,
"cds_length": 765,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2100,
"mane_select": "ENST00000443193.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.319+827A>C",
"hgvs_p": null,
"transcript": "ENST00000443193.6",
"protein_id": "ENSP00000392047.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 254,
"cds_start": -4,
"cds_end": null,
"cds_length": 765,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2100,
"mane_select": "NM_000569.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ENSG00000289768",
"gene_hgnc_id": null,
"hgvs_c": "c.316+827A>C",
"hgvs_p": null,
"transcript": "ENST00000699402.1",
"protein_id": "ENSP00000514363.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 155,
"cds_start": -4,
"cds_end": null,
"cds_length": 468,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 578,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.631+827A>C",
"hgvs_p": null,
"transcript": "NM_001127592.2",
"protein_id": "NP_001121064.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 358,
"cds_start": -4,
"cds_end": null,
"cds_length": 1077,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2382,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.634+827A>C",
"hgvs_p": null,
"transcript": "NM_001329122.1",
"protein_id": "NP_001316051.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 273,
"cds_start": -4,
"cds_end": null,
"cds_length": 822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2127,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.319+827A>C",
"hgvs_p": null,
"transcript": "ENST00000699401.1",
"protein_id": "ENSP00000514362.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 269,
"cds_start": -4,
"cds_end": null,
"cds_length": 810,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2227,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.319+827A>C",
"hgvs_p": null,
"transcript": "ENST00000699398.1",
"protein_id": "ENSP00000514359.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 262,
"cds_start": -4,
"cds_end": null,
"cds_length": 789,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3613,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.319+827A>C",
"hgvs_p": null,
"transcript": "NM_001127593.1",
"protein_id": "NP_001121065.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 254,
"cds_start": -4,
"cds_end": null,
"cds_length": 765,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2173,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.319+827A>C",
"hgvs_p": null,
"transcript": "NM_001127595.2",
"protein_id": "NP_001121067.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 254,
"cds_start": -4,
"cds_end": null,
"cds_length": 765,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2153,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.319+827A>C",
"hgvs_p": null,
"transcript": "NM_001329120.2",
"protein_id": "NP_001316049.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 254,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 2164,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "FCGR3A",
"gene_hgnc_id": 3619,
"hgvs_c": "c.319+827A>C",
"hgvs_p": null,
"transcript": "ENST00000367967.8",
"protein_id": "ENSP00000356944.3",
"transcript_support_level": 3,
"aa_start": null,
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"cds_start": -4,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
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"gene_symbol": "FCGR3A",
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"hgvs_c": "c.319+827A>C",
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"transcript": "ENST00000436743.7",
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},
{
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"consequences": [
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],
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"exon_count": 6,
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"gene_symbol": "FCGR3A",
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"hgvs_c": "c.319+827A>C",
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"transcript": "ENST00000699395.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "FCGR3A",
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"hgvs_c": "c.319+827A>C",
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"transcript": "ENST00000699396.1",
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},
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],
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "FCGR3A",
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],
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"gene_symbol": "FCGR3A",
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"hgvs_c": "c.316+827A>C",
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"transcript": "NM_001386450.1",
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},
{
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"strand": false,
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],
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"intron_rank": 3,
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"gene_symbol": "FCGR3A",
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"hgvs_c": "c.316+827A>C",
"hgvs_p": null,
"transcript": "ENST00000426740.8",
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],
"exon_rank": null,
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"gene_symbol": "FCGR3A",
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],
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},
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],
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"gene_symbol": "FCGR3A",
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},
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 3,
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"gene_symbol": "FCGR3A",
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"hgvs_c": "n.313+827A>C",
"hgvs_p": null,
"transcript": "ENST00000476031.1",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ENSG00000273112",
"gene_hgnc_id": null,
"hgvs_c": "n.271+29457T>G",
"hgvs_p": null,
"transcript": "ENST00000537821.2",
"protein_id": null,
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{
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{
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{
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],
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}
],
"message": null
}