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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-1655477-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=1655477&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 1655477,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "ENST00000341832.11",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "NM_033486.3",
"protein_id": "NP_277021.2",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 782,
"cds_start": 119,
"cds_end": null,
"cds_length": 2349,
"cdna_start": 223,
"cdna_end": null,
"cdna_length": 2992,
"mane_select": "ENST00000341832.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "ENST00000341832.11",
"protein_id": "ENSP00000463048.2",
"transcript_support_level": 1,
"aa_start": 40,
"aa_end": null,
"aa_length": 782,
"cds_start": 119,
"cds_end": null,
"cds_length": 2349,
"cdna_start": 223,
"cdna_end": null,
"cdna_length": 2992,
"mane_select": "NM_033486.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "ENST00000407249.7",
"protein_id": "ENSP00000464036.2",
"transcript_support_level": 1,
"aa_start": 40,
"aa_end": null,
"aa_length": 795,
"cds_start": 119,
"cds_end": null,
"cds_length": 2388,
"cdna_start": 231,
"cdna_end": null,
"cdna_length": 2677,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.17A>G",
"hgvs_p": "p.Asp6Gly",
"transcript": "ENST00000340677.9",
"protein_id": "ENSP00000464016.2",
"transcript_support_level": 1,
"aa_start": 6,
"aa_end": null,
"aa_length": 748,
"cds_start": 17,
"cds_end": null,
"cds_length": 2247,
"cdna_start": 278,
"cdna_end": null,
"cdna_length": 2534,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "n.119A>G",
"hgvs_p": null,
"transcript": "ENST00000611150.3",
"protein_id": "ENSP00000484222.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2350,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "n.119A>G",
"hgvs_p": null,
"transcript": "ENST00000615951.4",
"protein_id": "ENSP00000481846.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2227,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "NM_001787.3",
"protein_id": "NP_001778.2",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 795,
"cds_start": 119,
"cds_end": null,
"cds_length": 2388,
"cdna_start": 223,
"cdna_end": null,
"cdna_length": 3031,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "ENST00000629312.2",
"protein_id": "ENSP00000485849.1",
"transcript_support_level": 5,
"aa_start": 40,
"aa_end": null,
"aa_length": 785,
"cds_start": 119,
"cds_end": null,
"cds_length": 2358,
"cdna_start": 231,
"cdna_end": null,
"cdna_length": 2496,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "ENST00000629289.2",
"protein_id": "ENSP00000485937.1",
"transcript_support_level": 5,
"aa_start": 40,
"aa_end": null,
"aa_length": 783,
"cds_start": 119,
"cds_end": null,
"cds_length": 2352,
"cdna_start": 231,
"cdna_end": null,
"cdna_length": 2490,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "NM_001291345.2",
"protein_id": "NP_001278274.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 772,
"cds_start": 119,
"cds_end": null,
"cds_length": 2319,
"cdna_start": 223,
"cdna_end": null,
"cdna_length": 2962,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "ENST00000626918.2",
"protein_id": "ENSP00000485705.1",
"transcript_support_level": 5,
"aa_start": 40,
"aa_end": null,
"aa_length": 772,
"cds_start": 119,
"cds_end": null,
"cds_length": 2319,
"cdna_start": 231,
"cdna_end": null,
"cdna_length": 2457,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.17A>G",
"hgvs_p": "p.Asp6Gly",
"transcript": "NM_033489.3",
"protein_id": "NP_277024.2",
"transcript_support_level": null,
"aa_start": 6,
"aa_end": null,
"aa_length": 748,
"cds_start": 17,
"cds_end": null,
"cds_length": 2247,
"cdna_start": 270,
"cdna_end": null,
"cdna_length": 3039,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_011542490.4",
"protein_id": "XP_011540792.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 804,
"cds_start": 119,
"cds_end": null,
"cds_length": 2415,
"cdna_start": 223,
"cdna_end": null,
"cdna_length": 3058,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_011542491.3",
"protein_id": "XP_011540793.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 804,
"cds_start": 119,
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"cdna_start": 681,
"cdna_end": null,
"cdna_length": 3516,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_011542492.3",
"protein_id": "XP_011540794.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 804,
"cds_start": 119,
"cds_end": null,
"cds_length": 2415,
"cdna_start": 532,
"cdna_end": null,
"cdna_length": 3367,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_047435328.1",
"protein_id": "XP_047291284.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 795,
"cds_start": 119,
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"cdna_start": 681,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_047435330.1",
"protein_id": "XP_047291286.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 795,
"cds_start": 119,
"cds_end": null,
"cds_length": 2388,
"cdna_start": 532,
"cdna_end": null,
"cdna_length": 3340,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_011542493.4",
"protein_id": "XP_011540795.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 794,
"cds_start": 119,
"cds_end": null,
"cds_length": 2385,
"cdna_start": 223,
"cdna_end": null,
"cdna_length": 3028,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_017002925.3",
"protein_id": "XP_016858414.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 791,
"cds_start": 119,
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"cdna_start": 223,
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"mane_select": null,
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"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_006711065.5",
"protein_id": "XP_006711128.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 785,
"cds_start": 119,
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"cds_length": 2358,
"cdna_start": 223,
"cdna_end": null,
"cdna_length": 3001,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_047435362.1",
"protein_id": "XP_047291318.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 782,
"cds_start": 119,
"cds_end": null,
"cds_length": 2349,
"cdna_start": 352,
"cdna_end": null,
"cdna_length": 3121,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_017002926.3",
"protein_id": "XP_016858415.1",
"transcript_support_level": null,
"aa_start": 40,
"aa_end": null,
"aa_length": 781,
"cds_start": 119,
"cds_end": null,
"cds_length": 2346,
"cdna_start": 223,
"cdna_end": null,
"cdna_length": 2989,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "D",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CDK11B",
"gene_hgnc_id": 1729,
"hgvs_c": "c.119A>G",
"hgvs_p": "p.Asp40Gly",
"transcript": "XM_047435361.1",
"protein_id": "XP_047291317.1",
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"phenotype_combined": "Seizure",
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}
],
"message": null
}