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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-1707458-A-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=1707458&ref=A&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 1707458,
      "ref": "A",
      "alt": "G",
      "effect": "missense_variant",
      "transcript": "NM_001313896.2",
      "consequences": [
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1196T>C",
          "hgvs_p": "p.Leu399Ser",
          "transcript": "NM_024011.4",
          "protein_id": "NP_076916.2",
          "transcript_support_level": null,
          "aa_start": 399,
          "aa_end": null,
          "aa_length": 780,
          "cds_start": 1196,
          "cds_end": null,
          "cds_length": 2343,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000404249.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_024011.4"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1196T>C",
          "hgvs_p": "p.Leu399Ser",
          "transcript": "ENST00000404249.8",
          "protein_id": "ENSP00000384442.3",
          "transcript_support_level": 1,
          "aa_start": 399,
          "aa_end": null,
          "aa_length": 780,
          "cds_start": 1196,
          "cds_end": null,
          "cds_length": 2343,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_024011.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000404249.8"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1205T>C",
          "hgvs_p": "p.Leu402Ser",
          "transcript": "ENST00000378633.5",
          "protein_id": "ENSP00000367900.1",
          "transcript_support_level": 1,
          "aa_start": 402,
          "aa_end": null,
          "aa_length": 783,
          "cds_start": 1205,
          "cds_end": null,
          "cds_length": 2352,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000378633.5"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1193T>C",
          "hgvs_p": "p.Leu398Ser",
          "transcript": "ENST00000357760.6",
          "protein_id": "ENSP00000350403.2",
          "transcript_support_level": 1,
          "aa_start": 398,
          "aa_end": null,
          "aa_length": 779,
          "cds_start": 1193,
          "cds_end": null,
          "cds_length": 2340,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000357760.6"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1166T>C",
          "hgvs_p": "p.Leu389Ser",
          "transcript": "ENST00000358779.9",
          "protein_id": "ENSP00000351629.5",
          "transcript_support_level": 1,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 770,
          "cds_start": 1166,
          "cds_end": null,
          "cds_length": 2313,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000358779.9"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "n.1026T>C",
          "hgvs_p": null,
          "transcript": "ENST00000356937.7",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000356937.7"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": 11,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "n.1129+67T>C",
          "hgvs_p": null,
          "transcript": "ENST00000460465.5",
          "protein_id": "ENSP00000462289.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000460465.5"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1289T>C",
          "hgvs_p": "p.Leu430Ser",
          "transcript": "ENST00000893739.1",
          "protein_id": "ENSP00000563798.1",
          "transcript_support_level": null,
          "aa_start": 430,
          "aa_end": null,
          "aa_length": 811,
          "cds_start": 1289,
          "cds_end": null,
          "cds_length": 2436,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000893739.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1235T>C",
          "hgvs_p": "p.Leu412Ser",
          "transcript": "ENST00000893735.1",
          "protein_id": "ENSP00000563794.1",
          "transcript_support_level": null,
          "aa_start": 412,
          "aa_end": null,
          "aa_length": 793,
          "cds_start": 1235,
          "cds_end": null,
          "cds_length": 2382,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000893735.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1211T>C",
          "hgvs_p": "p.Leu404Ser",
          "transcript": "ENST00000893738.1",
          "protein_id": "ENSP00000563797.1",
          "transcript_support_level": null,
          "aa_start": 404,
          "aa_end": null,
          "aa_length": 785,
          "cds_start": 1211,
          "cds_end": null,
          "cds_length": 2358,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000893738.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1205T>C",
          "hgvs_p": "p.Leu402Ser",
          "transcript": "NM_001313896.2",
          "protein_id": "NP_001300825.1",
          "transcript_support_level": null,
          "aa_start": 402,
          "aa_end": null,
          "aa_length": 783,
          "cds_start": 1205,
          "cds_end": null,
          "cds_length": 2352,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001313896.2"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1193T>C",
          "hgvs_p": "p.Leu398Ser",
          "transcript": "NM_001313982.2",
          "protein_id": "NP_001300911.1",
          "transcript_support_level": null,
          "aa_start": 398,
          "aa_end": null,
          "aa_length": 779,
          "cds_start": 1193,
          "cds_end": null,
          "cds_length": 2340,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001313982.2"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1181T>C",
          "hgvs_p": "p.Leu394Ser",
          "transcript": "ENST00000893737.1",
          "protein_id": "ENSP00000563796.1",
          "transcript_support_level": null,
          "aa_start": 394,
          "aa_end": null,
          "aa_length": 775,
          "cds_start": 1181,
          "cds_end": null,
          "cds_length": 2328,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000893737.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1166T>C",
          "hgvs_p": "p.Leu389Ser",
          "transcript": "NM_033529.4",
          "protein_id": "NP_277071.2",
          "transcript_support_level": null,
          "aa_start": 389,
          "aa_end": null,
          "aa_length": 770,
          "cds_start": 1166,
          "cds_end": null,
          "cds_length": 2313,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_033529.4"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1160T>C",
          "hgvs_p": "p.Leu387Ser",
          "transcript": "ENST00000937803.1",
          "protein_id": "ENSP00000607862.1",
          "transcript_support_level": null,
          "aa_start": 387,
          "aa_end": null,
          "aa_length": 768,
          "cds_start": 1160,
          "cds_end": null,
          "cds_length": 2307,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000937803.1"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 10,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1094T>C",
          "hgvs_p": "p.Leu365Ser",
          "transcript": "ENST00000356200.7",
          "protein_id": "ENSP00000348529.2",
          "transcript_support_level": 5,
          "aa_start": 365,
          "aa_end": null,
          "aa_length": 746,
          "cds_start": 1094,
          "cds_end": null,
          "cds_length": 2241,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000356200.7"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 20,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.1094T>C",
          "hgvs_p": "p.Leu365Ser",
          "transcript": "ENST00000378638.6",
          "protein_id": "ENSP00000367905.1",
          "transcript_support_level": 5,
          "aa_start": 365,
          "aa_end": null,
          "aa_length": 746,
          "cds_start": 1094,
          "cds_end": null,
          "cds_length": 2241,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000378638.6"
        },
        {
          "aa_ref": "L",
          "aa_alt": "S",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "c.896T>C",
          "hgvs_p": "p.Leu299Ser",
          "transcript": "ENST00000893736.1",
          "protein_id": "ENSP00000563795.1",
          "transcript_support_level": null,
          "aa_start": 299,
          "aa_end": null,
          "aa_length": 680,
          "cds_start": 896,
          "cds_end": null,
          "cds_length": 2043,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000893736.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "n.104T>C",
          "hgvs_p": null,
          "transcript": "ENST00000468800.5",
          "protein_id": null,
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000468800.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK11A",
          "gene_hgnc_id": 1730,
          "hgvs_c": "n.194T>C",
          "hgvs_p": null,
          "transcript": "ENST00000474916.1",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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          "biotype": "retained_intron",
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      "computational_prediction_selected": "Benign",
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      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "revel_prediction": "Benign",
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      "bayesdelnoaf_score": -0.67,
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      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
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      "acmg_classification": "Benign",
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          "transcript": "NM_001313896.2",
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        {
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          ],
          "verdict": "Benign",
          "transcript": "ENST00000598846.1",
          "gene_symbol": "ENSG00000268575",
          "hgnc_id": null,
          "effects": [
            "intron_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.3863+67T>C",
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      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.