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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-173825273-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=173825273&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 173825273,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_018122.5",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "NM_018122.5",
"protein_id": "NP_060592.2",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 645,
"cds_start": 44,
"cds_end": null,
"cds_length": 1938,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000649689.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018122.5"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000649689.2",
"protein_id": "ENSP00000497569.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 645,
"cds_start": 44,
"cds_end": null,
"cds_length": 1938,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_018122.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000649689.2"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000647645.1",
"protein_id": "ENSP00000497450.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 624,
"cds_start": 44,
"cds_end": null,
"cds_length": 1875,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000647645.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000893356.1",
"protein_id": "ENSP00000563415.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 613,
"cds_start": 44,
"cds_end": null,
"cds_length": 1842,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893356.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000893354.1",
"protein_id": "ENSP00000563413.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 611,
"cds_start": 44,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893354.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000893363.1",
"protein_id": "ENSP00000563422.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 609,
"cds_start": 44,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893363.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000893361.1",
"protein_id": "ENSP00000563420.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 608,
"cds_start": 44,
"cds_end": null,
"cds_length": 1827,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893361.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "NM_001365212.1",
"protein_id": "NP_001352141.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 594,
"cds_start": 44,
"cds_end": null,
"cds_length": 1785,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001365212.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000648807.1",
"protein_id": "ENSP00000497472.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 594,
"cds_start": 44,
"cds_end": null,
"cds_length": 1785,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000648807.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000919979.1",
"protein_id": "ENSP00000590038.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 585,
"cds_start": 44,
"cds_end": null,
"cds_length": 1758,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919979.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000893359.1",
"protein_id": "ENSP00000563418.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 579,
"cds_start": 44,
"cds_end": null,
"cds_length": 1740,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893359.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000919980.1",
"protein_id": "ENSP00000590039.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 575,
"cds_start": 44,
"cds_end": null,
"cds_length": 1728,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919980.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000919981.1",
"protein_id": "ENSP00000590040.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 574,
"cds_start": 44,
"cds_end": null,
"cds_length": 1725,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919981.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000893357.1",
"protein_id": "ENSP00000563416.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 573,
"cds_start": 44,
"cds_end": null,
"cds_length": 1722,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893357.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000966171.1",
"protein_id": "ENSP00000636230.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 562,
"cds_start": 44,
"cds_end": null,
"cds_length": 1689,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000966171.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000919982.1",
"protein_id": "ENSP00000590041.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 560,
"cds_start": 44,
"cds_end": null,
"cds_length": 1683,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919982.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000893355.1",
"protein_id": "ENSP00000563414.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 557,
"cds_start": 44,
"cds_end": null,
"cds_length": 1674,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893355.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000649067.1",
"protein_id": "ENSP00000497052.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 539,
"cds_start": 44,
"cds_end": null,
"cds_length": 1620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000649067.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000893362.1",
"protein_id": "ENSP00000563421.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 535,
"cds_start": 44,
"cds_end": null,
"cds_length": 1608,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893362.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000919983.1",
"protein_id": "ENSP00000590042.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 526,
"cds_start": 44,
"cds_end": null,
"cds_length": 1581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000919983.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000893358.1",
"protein_id": "ENSP00000563417.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 489,
"cds_start": 44,
"cds_end": null,
"cds_length": 1470,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893358.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DARS2",
"gene_hgnc_id": 25538,
"hgvs_c": "c.44C>G",
"hgvs_p": "p.Ser15Cys",
"transcript": "ENST00000648960.1",
"protein_id": "ENSP00000497091.1",
"transcript_support_level": null,
"aa_start": 15,
"aa_end": null,
"aa_length": 484,
"cds_start": 44,
"cds_end": null,
"cds_length": 1455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000648960.1"
},
{
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}
],
"message": null
}