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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 1-17438318-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=17438318&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "1",
      "pos": 17438318,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_018715.4",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "NM_018715.4",
          "protein_id": "NP_061185.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000375436.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_018715.4"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000375436.9",
          "protein_id": "ENSP00000364585.4",
          "transcript_support_level": 1,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_018715.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000375436.9"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000375433.3",
          "protein_id": "ENSP00000364582.3",
          "transcript_support_level": 1,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000375433.3"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927104.1",
          "protein_id": "ENSP00000597163.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 548,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1647,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927104.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "NM_001136204.3",
          "protein_id": "NP_001129676.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001136204.3"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927084.1",
          "protein_id": "ENSP00000597143.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927084.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927093.1",
          "protein_id": "ENSP00000597152.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927093.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927109.1",
          "protein_id": "ENSP00000597169.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 521,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1566,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927109.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927087.1",
          "protein_id": "ENSP00000597145.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 519,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1560,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927087.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927088.1",
          "protein_id": "ENSP00000597146.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 519,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1560,
          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927088.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
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          "protein_coding": true,
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          ],
          "exon_rank": 1,
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          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927099.1",
          "protein_id": "ENSP00000597157.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 519,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1560,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927099.1"
        },
        {
          "aa_ref": "G",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
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          "exon_rank": 1,
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          "exon_count": 12,
          "intron_rank": null,
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          "gene_symbol": "RCC2",
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          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
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          "protein_id": "ENSP00000597158.1",
          "transcript_support_level": null,
          "aa_start": 66,
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          "cds_start": 197,
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          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        {
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          "exon_rank": 2,
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          "gene_symbol": "RCC2",
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          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000878232.1",
          "protein_id": "ENSP00000548291.1",
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          "biotype": "protein_coding",
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        {
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          "protein_coding": true,
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          "consequences": [
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          ],
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          "exon_count": 11,
          "intron_rank": null,
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          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927098.1",
          "protein_id": "ENSP00000597156.1",
          "transcript_support_level": null,
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        {
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          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927091.1",
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          "biotype": "protein_coding",
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        {
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          "exon_count": 12,
          "intron_rank": null,
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          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927086.1",
          "protein_id": "ENSP00000597144.1",
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          "cds_start": 197,
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        {
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          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927095.1",
          "protein_id": "ENSP00000597154.1",
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          "gene_symbol": "RCC2",
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        {
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        {
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          "protein_coding": true,
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          ],
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          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927089.1",
          "protein_id": "ENSP00000597147.1",
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          "aa_end": null,
          "aa_length": 410,
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        },
        {
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          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927102.1",
          "protein_id": "ENSP00000597161.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 410,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1233,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927102.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927092.1",
          "protein_id": "ENSP00000597151.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 376,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1131,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927092.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927090.1",
          "protein_id": "ENSP00000597149.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 362,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1089,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927090.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "RCC2",
          "gene_hgnc_id": 30297,
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp",
          "transcript": "ENST00000927097.1",
          "protein_id": "ENSP00000597155.1",
          "transcript_support_level": null,
          "aa_start": 66,
          "aa_end": null,
          "aa_length": 362,
          "cds_start": 197,
          "cds_end": null,
          "cds_length": 1089,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000927097.1"
        }
      ],
      "gene_symbol": "RCC2",
      "gene_hgnc_id": 30297,
      "dbsnp": "rs1454626195",
      "frequency_reference_population": null,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 0,
      "gnomad_exomes_af": 0,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 0,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.10881394147872925,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.009999999776482582,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.032,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.2196,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.54,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 0.35,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0.01,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": 0,
          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_018715.4",
          "gene_symbol": "RCC2",
          "hgnc_id": 30297,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.197G>A",
          "hgvs_p": "p.Gly66Asp"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}