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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 1-174854701-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=1&pos=174854701&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "1",
"pos": 174854701,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_001366446.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.2340+42741A>T",
"hgvs_p": null,
"transcript": "NM_001366446.1",
"protein_id": "NP_001353375.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1051,
"cds_start": -4,
"cds_end": null,
"cds_length": 3156,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8634,
"mane_select": "ENST00000681986.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.2340+42741A>T",
"hgvs_p": null,
"transcript": "ENST00000681986.1",
"protein_id": "ENSP00000507884.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1051,
"cds_start": -4,
"cds_end": null,
"cds_length": 3156,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8634,
"mane_select": "NM_001366446.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.321+42741A>T",
"hgvs_p": null,
"transcript": "ENST00000347255.6",
"protein_id": "ENSP00000281844.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 378,
"cds_start": -4,
"cds_end": null,
"cds_length": 1137,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1744,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.297+42741A>T",
"hgvs_p": null,
"transcript": "ENST00000489615.5",
"protein_id": "ENSP00000420660.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 370,
"cds_start": -4,
"cds_end": null,
"cds_length": 1113,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6821,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.261+42741A>T",
"hgvs_p": null,
"transcript": "ENST00000325589.9",
"protein_id": "ENSP00000318603.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 358,
"cds_start": -4,
"cds_end": null,
"cds_length": 1077,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1880,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "n.262-22691A>T",
"hgvs_p": null,
"transcript": "ENST00000469553.6",
"protein_id": "ENSP00000432734.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2103,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.2340+42741A>T",
"hgvs_p": null,
"transcript": "NM_001366448.1",
"protein_id": "NP_001353377.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 985,
"cds_start": -4,
"cds_end": null,
"cds_length": 2958,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8436,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.2340+42741A>T",
"hgvs_p": null,
"transcript": "NM_014857.5",
"protein_id": "NP_055672.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 815,
"cds_start": -4,
"cds_end": null,
"cds_length": 2448,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2901,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.2340+42741A>T",
"hgvs_p": null,
"transcript": "ENST00000251507.8",
"protein_id": "ENSP00000251507.4",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 815,
"cds_start": -4,
"cds_end": null,
"cds_length": 2448,
"cdna_start": null,
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"cdna_length": 2899,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.2229+42741A>T",
"hgvs_p": null,
"transcript": "NM_001366447.1",
"protein_id": "NP_001353376.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 778,
"cds_start": -4,
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"cds_length": 2337,
"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.321+42741A>T",
"hgvs_p": null,
"transcript": "NM_001366452.1",
"protein_id": "NP_001353381.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 11,
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"gene_symbol": "RABGAP1L",
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"hgvs_c": "c.318+42741A>T",
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"transcript": "ENST00000367687.5",
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},
{
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"strand": true,
"consequences": [
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],
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"gene_symbol": "RABGAP1L",
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"hgvs_c": "c.297+42741A>T",
"hgvs_p": null,
"transcript": "NM_001243765.2",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 4,
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"gene_symbol": "RABGAP1L",
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"hgvs_c": "c.261+42741A>T",
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"transcript": "NM_001366450.1",
"protein_id": "NP_001353379.1",
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},
{
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"strand": true,
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],
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"gene_symbol": "RABGAP1L",
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"hgvs_c": "c.-103-22691A>T",
"hgvs_p": null,
"transcript": "NM_001330989.2",
"protein_id": "NP_001317918.1",
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},
{
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],
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"gene_symbol": "RABGAP1L",
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"hgvs_c": "c.297+42741A>T",
"hgvs_p": null,
"transcript": "NM_001366456.1",
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},
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],
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"intron_rank": 4,
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"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.-542-22691A>T",
"hgvs_p": null,
"transcript": "NM_001366451.1",
"protein_id": "NP_001353380.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.-103-22691A>T",
"hgvs_p": null,
"transcript": "NM_001366454.1",
"protein_id": "NP_001353383.1",
"transcript_support_level": null,
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},
{
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],
"exon_rank": null,
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"gene_symbol": "RABGAP1L",
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"hgvs_c": "c.318+42741A>T",
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"transcript": "NM_001366453.1",
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],
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"hgvs_c": "c.297+42741A>T",
"hgvs_p": null,
"transcript": "NM_001366455.1",
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},
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],
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},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "n.2512-22691A>T",
"hgvs_p": null,
"transcript": "NR_158982.1",
"protein_id": null,
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"aa_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "RABGAP1L",
"gene_hgnc_id": 24663,
"hgvs_c": "c.2340+42741A>T",
"hgvs_p": null,
"transcript": "XM_011510223.3",
"protein_id": "XP_011508525.1",
"transcript_support_level": null,
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}